{"id":"https://openalex.org/W2402085136","doi":null,"title":"Single centre study of using bendamustine in the treatment of B-cell malignancies.","display_name":"Single centre study of using bendamustine in the treatment of B-cell malignancies.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W2402085136","mag":"2402085136","pmid":"https://pubmed.ncbi.nlm.nih.gov/23901668"},"language":"en","primary_location":{"id":"pmid:23901668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23901668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JPMA. The Journal of the Pakistan Medical Association","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/47","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010245870","display_name":"Asif Husain Osmani","orcid":"https://orcid.org/0000-0003-0254-766X","observed_orcids":["https://orcid.org/0000-0003-0254-766X"]},"institutions":[{"id":"https://openalex.org/I118185606","display_name":"Aga Khan University","ror":"https://ror.org/03gd0dm95","country_code":"PK","type":"education","lineage":["https://openalex.org/I118185606","https://openalex.org/I4210114929"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Asif Husain Osmani","raw_affiliation_strings":["Hematology/0ncology Section, Department of Medicine, Aga Khan University, Karachi, Pakistan. asif.osmani@aku.edu","Hematology/0ncology Section, Department of Medicine, Aga Khan University, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/0ncology Section, Department of Medicine, Aga Khan University, Karachi, Pakistan. asif.osmani@aku.edu","institution_ids":["https://openalex.org/I118185606"]},{"raw_affiliation_string":"Hematology/0ncology Section, Department of Medicine, Aga Khan University, Karachi, Pakistan","institution_ids":["https://openalex.org/I118185606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111790246","display_name":"Nehal Masood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nehal Masood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2626,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5757127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"6","first_page":"702","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bendamustine","display_name":"bendamustine","score":1.0},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.9890000224113464},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":1.0},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/skin-toxicity","display_name":"skin toxicity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8669999837875366},{"id":"https://openalex.org/keywords/relapsed-disease","display_name":"relapsed disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.9913917183876038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9501582980155945},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.6742401123046875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6675890684127808},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5602923631668091},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.4960401952266693},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.48132026195526123},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4248775243759155},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.2683570384979248},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.16323626041412354}],"mesh":[{"descriptor_ui":"D000069461","descriptor_name":"Bendamustine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009588","descriptor_name":"Nitrogen Mustard Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:23901668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23901668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JPMA. The Journal of the Pakistan Medical Association","raw_type":"Comparative Study"},{"id":"pmh:oai:ecommons.aku.edu:pakistan_fhs_mc_radiat_oncol-1047","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/47","pdf_url":"https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/47","source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Radiation Oncology","raw_type":"article"},{"id":"mag:2402085136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23901668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.aku.edu:pakistan_fhs_mc_radiat_oncol-1047","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/47","pdf_url":"https://ecommons.aku.edu/pakistan_fhs_mc_radiat_oncol/47","source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Radiation Oncology","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2402085136.pdf","grobid_xml":"https://content.openalex.org/works/W2402085136.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1970873656","https://openalex.org/W1976127594","https://openalex.org/W1979223485","https://openalex.org/W2014631400","https://openalex.org/W2058015212","https://openalex.org/W2061740861","https://openalex.org/W2084694447","https://openalex.org/W2116913418","https://openalex.org/W2117541387","https://openalex.org/W2120373806","https://openalex.org/W2120755425","https://openalex.org/W2128936398","https://openalex.org/W2142019712","https://openalex.org/W2161445501","https://openalex.org/W2163348695","https://openalex.org/W2168399216","https://openalex.org/W2414028684","https://openalex.org/W2562994716"],"related_works":["https://openalex.org/W2276425403","https://openalex.org/W2557299841","https://openalex.org/W2552655319","https://openalex.org/W2154037106","https://openalex.org/W2086323562","https://openalex.org/W2083329993","https://openalex.org/W2005893097","https://openalex.org/W2247387363","https://openalex.org/W1929971903","https://openalex.org/W2117541387"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,8,40,65,190],"experience":[4],"of":[5,10,25,84,132,158,192],"bendamustine":[6,34,127],"in":[7,183,189],"treatment":[9,191],"B-cell":[11,30,102,195],"malignancies":[12,31],"at":[13,39],"a":[14,82],"tertiary":[15],"care":[16],"centre.":[17],"METHODS:":[18],"The":[19],"retrospective":[20],"descriptive":[21],"analysis":[22],"included":[23,136],"data":[24],"all":[26],"adult":[27],"patients":[28,67,113,123,153,193],"with":[29,33,126,194],"treated":[32,125],"from":[35],"2009":[36],"to":[37],"2011":[38],"Aga":[41],"Khan":[42],"University":[43],"Hospital,":[44],"Karachi.":[45],"Data":[46],"was":[47,79],"analysed":[48],"using":[49],"SPSS":[50],"17.0.":[51],"Frequencies":[52],"and":[53,61,72,104,117,145,165,187],"percentages":[54],"were":[55,70,75,124,135],"computed":[56],"for":[57,137],"baseline":[58],"characteristics,":[59],"responses":[60],"toxicities.":[62,120],"RESULTS:":[63],"Of":[64],"19":[66],"15":[68],"(79%)":[69],"males":[71],"4":[73,118],"(21%)":[74,112],"females.The":[76],"mean":[77],"age":[78],"59.53+/-12.14":[80],"(with":[81],"range":[83],"46-86).":[85],"Eight":[86,121],"(42%)":[87,122],"had":[88,93,99,107,142,148,154,162,168,174],"follicular":[89],"lymphoma,":[90,96,103],"6":[91],"(32%)":[92],"mantle":[94],"cell":[95],"2":[97],"(11%)":[98],"diffuse":[100],"large":[101],"3":[105,116,140,146,160],"(16%)":[106],"chronic":[108],"lymphocytic":[109],"leukaemia.":[110],"Four":[111],"experienced":[114],"grades":[115],"cutaneous":[119],"as":[128,180],"first-line":[129],"therapy.":[130],"Six":[131],"them":[133],"(75%)":[134],"response":[138],"evaluation;":[139],"(50%)":[141,147],"complete":[143,163],"response,":[144,164,170],"partial":[149,169],"response.":[150],"Eleven":[151],"(58%)":[152],"relapsed":[155],"disease":[156,175],"out":[157],"which":[159],"(27.27%)":[161],"7":[166],"(63.63%)":[167],"whereas":[171],"1":[172],"(9%)":[173],"progression.":[176],"CONCLUSION:":[177],"Bendamustine":[178],"given":[179],"monotherapy":[181],"or":[182],"combination":[184],"is":[185],"safe":[186],"useful":[188],"malignancies.":[196]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
