{"id":"https://openalex.org/W2402016316","doi":null,"title":"Soluble immunological parameters and early prognosis of renal cell cancer patients.","display_name":"Soluble immunological parameters and early prognosis of renal cell cancer patients.","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2402016316","mag":"2402016316","pmid":"https://pubmed.ncbi.nlm.nih.gov/11876546"},"language":"en","primary_location":{"id":"pmid:11876546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11876546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073384460","display_name":"JUKKA P. KALLIO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]},{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J P Kallio","raw_affiliation_strings":["Division of Urology, Tampere University Hospital, University of Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Tampere University Hospital, University of Tampere, Finland","institution_ids":["https://openalex.org/I4210126318","https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011425417","display_name":"Teuvo L.J. Tammela","orcid":"https://orcid.org/0000-0002-3529-4649","observed_orcids":["https://orcid.org/0000-0002-3529-4649","https://orcid.org/0009-0005-0435-9613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T L Tammela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A T Marttinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A T Marttinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108588816","display_name":"Pirkko Kellokumpu\u2010Lehtinen","orcid":"https://orcid.org/0000-0002-5557-0911","observed_orcids":["https://orcid.org/0000-0002-5557-0911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Kellokumpu-Lehtinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8728,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.753519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"4","first_page":"523","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8939999938011169},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9959999918937683},{"id":"https://openalex.org/keywords/soluble-il-2-receptor","display_name":"soluble interleukin-2 receptor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/soluble-intercellular-adhesion-molecule-1","display_name":"soluble intercellular adhesion molecule-1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.7120000123977661},{"id":"https://openalex.org/keywords/short-term-survival","display_name":"short-term survival","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6875863671302795},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6642372608184814},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.6325379610061646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5552117228507996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5410096049308777},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.5370112657546997},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.475483775138855},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.43498367071151733},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.43375495076179504},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4046202600002289},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3572114109992981},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.34204208850860596},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3304332494735718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2388896942138672},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17894187569618225}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11876546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11876546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Comparative Study"},{"id":"mag:2402016316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11876546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3038844630","https://openalex.org/W2021743788","https://openalex.org/W2151433618","https://openalex.org/W2125684320","https://openalex.org/W2001370818","https://openalex.org/W2968153353","https://openalex.org/W2617615383","https://openalex.org/W1550874198","https://openalex.org/W7208345046","https://openalex.org/W1965887187"],"abstract_inverted_index":{"In":[0,20,126,180,207],"local":[1,104,133,156,161],"or":[2],"metastatic":[3],"cancer,":[4],"a":[5,11,171,241],"prognostic":[6,244],"tumour":[7,41,152,173],"marker":[8],"could":[9],"be":[10],"valuable":[12],"tool":[13],"in":[14,47,79,99,103,132,153,191,226,246],"the":[15,34,140,150],"selection":[16],"of":[17,149],"different":[18],"treatments.":[19],"renal":[21],"cell":[22],"cancer":[23],"(RCC)":[24],"no":[25],"such":[26],"markers":[27],"have":[28,240],"been":[29],"available.":[30],"We":[31],"therefore":[32],"evaluated":[33],"association":[35],"between":[36],"several":[37,227],"pretreatment":[38],"serum":[39,80],"markers,":[40],"classification":[42],"and":[43,56,72,91,113,139,183,203,237],"short":[44,194],"term":[45],"survival":[46,199,212],"RCC":[48,62,223],"patients.":[49,63],"Serum":[50,88],"samples":[51,81],"were":[52,77,96,130,188],"collected":[53],"before":[54,94,186],"surgery":[55],"three":[57],"months":[58],"thereafter":[59],"from":[60],"24":[61],"Interleukin-6":[64],"(IL-6),":[65],"IL-":[66],"12,":[67],"soluble":[68,231],"IL-2":[69],"receptor":[70],"(sIL-2R)":[71],"intercellular":[73],"adhesion":[74],"molecule-1":[75],"(sICAM-1)":[76],"measured":[78],"using":[82],"specific":[83],"commercial":[84],"enzyme":[85],"immunoassay":[86],"kits.":[87],"IL-6,":[89,234],"sIL-2R":[90,120,236],"sICAM-1":[92,114,184],"levels":[93,129,141,176,185],"nephrectomy":[95],"significantly":[97,143,189,214],"higher":[98,131,190],"non-local":[100,172],"tumours":[101,134,162],"than":[102,196],"ones":[105],"(mean":[106],"IL-6":[107,165,175,182,202],"53":[108],"pg/ml":[109,122],"versus":[110,117,123,136],"6.3":[111],"pg/ml,":[112],"443":[115],"ng/ml":[116],"290":[118],"ng/ml,":[119],"3779":[121],"1796":[124],"pg/ml).":[125],"contrast,":[127,208],"IL-12":[128,216],"(148":[135],"102":[137],"pg/ml)":[138],"increased":[142],"(P":[144],"<":[145],"0.005)":[146],"after":[147],"removal":[148],"primary":[151],"patients":[154,159,192,209],"with":[155,160,170,193,210],"disease.":[157],"All":[158],"had":[163,174,213],"normal":[164],"values,":[166],"while":[167],"only":[168],"one":[169,197],"below":[177],"10":[178],"pg/ml.":[179],"addition,":[181],"operation":[187],"(less":[195],"year)":[198],"(p=0.007":[200],"to":[201,205],"p=0.006":[204],"sICAM-1).":[206],"shorter":[211],"lower":[215],"(p=0.03)":[217],"levels.":[218],"Our":[219],"findings":[220],"suggest":[221],"that":[222],"induces":[224],"changes":[225],"immunological":[228,232],"parameters.":[229],"These":[230],"factors,":[233],"IL-12,":[235],"sICAM-1,":[238],"might":[239],"role":[242],"as":[243],"factors":[245],"RCC.":[247]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}