{"id":"https://openalex.org/W2401916163","doi":null,"title":"Neuroprotective Effect of Estrogen on Motor Neuron Cells Expressing Wild Type or Mutant Cu/Zn Superoxide Dismutase.","display_name":"Neuroprotective Effect of Estrogen on Motor Neuron Cells Expressing Wild Type or Mutant Cu/Zn Superoxide Dismutase.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2401916163","mag":"2401916163"},"language":"en","primary_location":{"id":"mag:2401916163","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=HKSKCS_2002_v20n5_525","pdf_url":null,"source":{"id":"https://openalex.org/S2764848346","display_name":"Journal of the Korean Neurological Association","issn_l":"1225-7044","issn":["1225-7044","2288-985X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4324031397","host_organization_name":"Korean Neurological Association","host_organization_lineage":["https://openalex.org/P4324031397"],"host_organization_lineage_names":["Korean Neurological Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Korean Neurological Association","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076649890","display_name":"Han\u2010Joon Kim","orcid":"https://orcid.org/0000-0001-8219-9663","observed_orcids":["https://orcid.org/0000-0001-8219-9663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han\u2010Joon Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8219-9663","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080456346","display_name":"Seong-Ho Park","orcid":"https://orcid.org/0000-0002-0504-2539","observed_orcids":["https://orcid.org/0000-0002-0504-2539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seong-Ho Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0504-2539","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048712323","display_name":"Man-Ho Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Man-Ho Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439530","display_name":"Hyun\u2010Jung Kim","orcid":"https://orcid.org/0000-0002-4041-0018","observed_orcids":["https://orcid.org/0000-0002-4041-0018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyun\u2010Jung Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4041-0018","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088451675","display_name":"Kwang\u2010Woo Lee","orcid":"https://orcid.org/0000-0001-6187-1457","observed_orcids":["https://orcid.org/0000-0001-6187-1457","https://orcid.org/0000-0002-8882-2492","https://orcid.org/0000-0003-0700-2298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwang\u2010Woo Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6187-1457","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.32323404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"20","issue":"5","first_page":"525","last_page":"529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cu-zn-superoxide-dismutase","display_name":"Cu/Zn superoxide dismutase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/s-nitrosoglutathione","display_name":"S-nitrosoglutathione","score":0.8700000047683716},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.828000009059906},{"id":"https://openalex.org/keywords/a4v-mutation","display_name":"A4V mutation","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9606373310089111},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7282029390335083},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.6339151859283447},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6211466789245605},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5616158843040466},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4934910535812378},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4870315194129944},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3684583306312561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.364773154258728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3201112747192383},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3074319362640381},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2778790593147278},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2572687268257141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24932318925857544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24509140849113464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24389824271202087},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22882258892059326},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2401916163","doi":null,"is_oa":false,"landing_page_url":"http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=HKSKCS_2002_v20n5_525","pdf_url":null,"source":{"id":"https://openalex.org/S2764848346","display_name":"Journal of the Korean Neurological Association","issn_l":"1225-7044","issn":["1225-7044","2288-985X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4324031397","host_organization_name":"Korean Neurological Association","host_organization_lineage":["https://openalex.org/P4324031397"],"host_organization_lineage_names":["Korean Neurological Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Korean Neurological Association","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W55299133","https://openalex.org/W69871636","https://openalex.org/W1771495220","https://openalex.org/W1821318981","https://openalex.org/W1963092557","https://openalex.org/W1971476985","https://openalex.org/W1977577190","https://openalex.org/W2020914812","https://openalex.org/W2037148314","https://openalex.org/W2047512466","https://openalex.org/W2055317912","https://openalex.org/W2064890294","https://openalex.org/W2090816846","https://openalex.org/W2095410649","https://openalex.org/W2096386031","https://openalex.org/W2110580010","https://openalex.org/W2111398489","https://openalex.org/W2125501179","https://openalex.org/W2149497936"],"related_works":["https://openalex.org/W2559950724","https://openalex.org/W2063838755","https://openalex.org/W2080228411","https://openalex.org/W2785881762","https://openalex.org/W1979626900","https://openalex.org/W2062217279","https://openalex.org/W1995764642","https://openalex.org/W2073291479","https://openalex.org/W155265769","https://openalex.org/W2010476245"],"abstract_inverted_index":{"Background":[0],":":[1,85,138,201],"Recently,":[2],"the":[3,117],"mechanism":[4],"involved":[5],"in":[6,28,38,52,64,144,156,170,223],"nitric":[7],"oxide":[8],"(NO)-mediated":[9],"motor":[10,40,54,75,207],"neuron":[11,41,55,76,208],"death":[12,42,152,209],"is":[13,26,45,58,230],"under":[14],"extensive":[15],"investigation.":[16],"The":[17],"role":[18,51],"of":[19,31,120,150,217,221,228],"Cu/Zn":[20],"superoxide":[21],"dismutase":[22],"(SOD)":[23],"mutation,":[24],"which":[25],"found":[27],"about":[29],"2%":[30],"all":[32,145],"ALS":[33,247],"patients,":[34],"has":[35,80],"been":[36,82],"implicated":[37],"selective":[39],"and":[43,163,219],"it":[44],"said":[46],"to":[47,60,78,245],"play":[48],"an":[49],"important":[50],"NO-mediated":[53,206],"death.":[56],"Estrogen":[57],"reported":[59],"have":[61],"neuroprotective":[62,69,118,168,182,198],"effect":[63,70,119,143,169,227],"various":[65],"neurological":[66],"diseases.":[67],"However,":[68],"on":[71,73],"estradiol":[72,180,187,194,229],"spinal":[74],"exposed":[77],"NO":[79],"rarely":[81],"studied.":[83],"Methods":[84],"Motor":[86],"neuron-neuroblastoma":[87],"hybrid":[88],"cell":[89,108,147,151,158,172,176,192],"expressing":[90],"wild-type":[91,175],"or":[92,95,126,215],"mutant":[93],"(G93A":[94],"A4V)":[96],"SOD":[97,224,234],"gene":[98,235],"was":[99,110,130,153],"treated":[100],"with":[101,123],"200":[102],"M":[103],"Snitrosoglutathione.":[104],"After":[105],"24":[106,132],"hours,":[107],"viability":[109],"measured":[111],"by":[112,213,233],"MTT":[113],"assay.":[114],"To":[115],"see":[116],"estradiol,":[121],"pretreatment":[122],"5":[124,161,185],"nM":[125,128,162,165,179,186],"50":[127,164,178],"17-estradiols":[129],"done":[131],"hours":[133],"before":[134],"S-nitrosoglutathione":[135,139],"treatment.":[136],"Results":[137],"showed":[140,167,181,197,204],"significant":[141],"neurotoxic":[142],"three":[146],"lines.":[148],"Percentage":[149],"significantly":[154],"different":[155],"each":[157],"line.":[159,173],"Both":[160],"estradiols":[166],"G93A":[171],"In":[174,190],"line,":[177,193],"effect,":[183],"but":[184],"did":[188,195],"not.":[189],"A4V":[191],"not":[196],"effect.":[199],"Conclusions":[200],"This":[202,237],"study":[203,238],"that":[205,240],"could":[210],"be":[211,243],"influenced":[212,232],"presence":[214],"absence":[216],"mutation":[218,222],"type":[220],"gene.":[225],"Neuroprotective":[226],"also":[231],"mutation.":[236],"implies":[239],"estrogen":[241],"might":[242],"beneficial":[244],"some":[246],"patients.":[248]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
