{"id":"https://openalex.org/W2401589271","doi":null,"title":"Chronic unilateral ureteral obstruction is associated with interstitial fibrosis and tubular expression of transforming growth factor-beta.","display_name":"Chronic unilateral ureteral obstruction is associated with interstitial fibrosis and tubular expression of transforming growth factor-beta.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W2401589271","mag":"2401589271","pmid":"https://pubmed.ncbi.nlm.nih.gov/8780170"},"language":"en","primary_location":{"id":"pmid:8780170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044584553","display_name":"Wright Ej","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E J Wright","raw_affiliation_strings":["Department of Urology, James Buchanan Brady Foundation, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, James Buchanan Brady Foundation, New York, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044219724","display_name":"McCaffrey Ta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T A McCaffrey","raw_affiliation_strings":["cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020234897","display_name":"Robertson Ap","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A P Robertson","raw_affiliation_strings":["James Buchanan Brady Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Buchanan Brady Foundation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020741929","display_name":"E D Vaughan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Vaughan","raw_affiliation_strings":["James Buchanan Brady Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Buchanan Brady Foundation","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068682755","display_name":"Diane Felsen","orcid":"https://orcid.org/0000-0003-1190-9626","observed_orcids":["https://orcid.org/0000-0003-1190-9626"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Felsen","raw_affiliation_strings":["Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1397,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.96777003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"74","issue":"2","first_page":"528","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12634","display_name":"Ureteral procedures and complications","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8569999933242798},{"id":"https://openalex.org/keywords/renal-extracellular-matrix","display_name":"renal extracellular matrix","score":0.8209999799728394},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8709999918937683},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7009999752044678},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.6919999718666077},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":1.0},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.7310788631439209},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6471142768859863},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6334686875343323},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6331697106361389},{"id":"https://openalex.org/C163031210","wikidata":"https://www.wikidata.org/wiki/Q3325848","display_name":"Masson's trichrome stain","level":3,"score":0.6141458749771118},{"id":"https://openalex.org/C150489694","wikidata":"https://www.wikidata.org/wiki/Q6057172","display_name":"Interstitial space","level":2,"score":0.5511549711227417},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5472724437713623},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4718888998031616},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.46578943729400635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41970765590667725},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4132375717163086},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.4119545519351959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33997848629951477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3353733718395233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33344537019729614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8780170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:2401589271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032261477","https://openalex.org/W2019578708","https://openalex.org/W1968002331","https://openalex.org/W2029019982","https://openalex.org/W2032667836","https://openalex.org/W2194525164","https://openalex.org/W1488897709","https://openalex.org/W2389684165","https://openalex.org/W2348899251","https://openalex.org/W2011121342"],"abstract_inverted_index":{"Chronic":[0],"unilateral":[1],"ureteral":[2],"obstruction":[3,41,61],"(UUO)":[4],"results":[5,42],"in":[6,21,32,43,45,59,116,120,161,167,174,179,188,194,203,213,236,244,287],"interstitial":[7,94,118,169,181,232,246],"fibrosis":[8,63,289],"and":[9,48,62,84,96,103,108,123,134,144,150,166,249,251,258],"nephron":[10],"damage":[11],"associated":[12,153,199,230,271,290],"with":[13,154,200,221,231,272,291],"irreversible":[14],"loss":[15],"of":[16,26,73,77,93,141,223,280],"function.":[17],"Collagen":[18,147],"is":[19,229,239],"increased":[20,139,262],"UUO,":[22,264],"but":[23,56,192,265],"detailed":[24],"studies":[25,98],"rat":[27],"renal":[28,46],"extracellular":[29,237],"matrix":[30,238],"changes":[31],"UUO":[33,76,133,197,228],"have":[34],"not":[35,65,172,193,267],"been":[36,66],"carried":[37,111],"out.":[38,112],"Acute":[39],"(3-day)":[40],"increases":[44,115,243],"macrophages":[47,109],"the":[49,69,117,155,168,180,245,252,273,288],"fibrogenic":[50,274],"cytokine":[51,275],"transforming":[52],"growth":[53],"factor-beta":[54],"(TGF-beta),":[55],"their":[57],"involvement":[58],"longer-term":[60],"has":[64],"studied.":[67],"In":[68,226],"present":[70],"experiments,":[71],"kidneys":[72],"rats":[74],"after":[75,132,183,263],"1,":[78],"2,":[79],"3,":[80],"7,":[81],"14,":[82],"21,":[83],"28":[85],"days'":[86],"duration":[87],"were":[88,110,127,136,158,177,219],"used.":[89],"Trichrome":[90],"staining,":[91],"measurement":[92],"volume,":[95],"immunohistochemical":[97],"localizing":[99],"collagens":[100,247],"I,":[101],"III,":[102],"IV;":[104],"laminin;":[105],"fibronectin;":[106],"TGF-beta;":[107],"We":[113],"found":[114,159,173,178,187,212],"space":[119,182],"both":[121,160,241],"cortex":[122],"medulla":[124],"that":[125],"(a)":[126],"significant":[128],"by":[129,138],"day":[130],"7":[131],"(b)":[135],"accompanied":[137],"deposition":[140],"collagen":[142,145,255],"I":[143,248],"III.":[146],"IV,":[148,256],"laminin,":[149,257],"fibronectin,":[151],"normally":[152],"basement":[156,164,253],"membrane,":[157],"a":[162,284],"thickened":[163],"membrane":[165],"space.":[170],"Macrophages,":[171],"sham-operated":[175],"kidneys,":[176],"UUO.":[184,292],"TGF-beta":[185,210,281],"was":[186,198,211],"sham":[189],"cortical":[190,204],"tubules,":[191],"medullary":[195,215],"tubules.":[196,216],"little":[201],"change":[202],"TGF-beta,":[205],"whereas":[206],"at":[207],"14":[208],"days,":[209],"dilated":[214],"Immunohistochemical":[217],"findings":[218],"confirmed":[220],"measurements":[222],"tissue":[224],"TGF-beta.":[225,276],"summary,":[227],"fibrosis.":[233],"The":[234],"increase":[235],"due":[240],"to":[242,269],"III":[250],"membrane-associated":[254],"fibronectin.":[259],"Macrophages":[260],"are":[261],"do":[266],"seem":[268],"be":[270,283],"Medullary":[277],"tubular":[278],"synthesis":[279],"may":[282],"contributing":[285],"factor":[286]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
