{"id":"https://openalex.org/W2401475254","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c59","title":"Induction of heme oxygenase-1 (HSP32) mRNA in skeletal muscle following contractions","display_name":"Induction of heme oxygenase-1 (HSP32) mRNA in skeletal muscle following contractions","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2401475254","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c59","mag":"2401475254","pmid":"https://pubmed.ncbi.nlm.nih.gov/9038811"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1997.272.1.c59","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c59","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1997.272.1.c59","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010873610","display_name":"David A. Essig","orcid":"https://orcid.org/0000-0001-5585-0115","observed_orcids":["https://orcid.org/0000-0001-5585-0115"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Essig","raw_affiliation_strings":["Department of Exercise Science, University of South Carolina, Columbia29210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, University of South Carolina, Columbia29210, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109408686","display_name":"Darrell R. Borger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. R. Borger","raw_affiliation_strings":["Department of Exercise Science, University of South Carolina, Columbia29210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, University of South Carolina, Columbia29210, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":null,"display_name":"D. A. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Jackson","raw_affiliation_strings":["Department of Exercise Science, University of South Carolina, Columbia29210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, University of South Carolina, Columbia29210, USA","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":1.0916,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.76327849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"272","issue":"1","first_page":"C59","last_page":"C67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.4993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.4993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.42260000109672546,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9200000166893005},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.734000027179718},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.7609999775886536},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.47699999809265137},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5509999990463257},{"id":"https://openalex.org/keywords/muscle-tension","display_name":"muscle tension","score":0.40299999713897705},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.7313438653945923},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6319109201431274},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6309396624565125},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5940653681755066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5384845733642578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5194558501243591},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5055842399597168},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4482840299606323},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.43460050225257874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42476287484169006},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.4147729277610779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3777962327003479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29205673933029175},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21392464637756348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11266860365867615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06019076704978943}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010543","descriptor_name":"Peroneal Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1997.272.1.c59","doi":"https://doi.org/10.1152/ajpcell.1997.272.1.c59","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1997.272.1.c59","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:9038811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9038811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8418326671","display_name":null,"funder_award_id":"AR-03987","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W182342000","https://openalex.org/W306426862","https://openalex.org/W1528630840","https://openalex.org/W1769448430","https://openalex.org/W1840625014","https://openalex.org/W1936536560","https://openalex.org/W1937949410","https://openalex.org/W1966582616","https://openalex.org/W1969048943","https://openalex.org/W1978537703","https://openalex.org/W1980920477","https://openalex.org/W1985096908","https://openalex.org/W2000254823","https://openalex.org/W2019079217","https://openalex.org/W2046901562","https://openalex.org/W2055533988","https://openalex.org/W2056194893","https://openalex.org/W2090389306","https://openalex.org/W2112442880","https://openalex.org/W2124433916","https://openalex.org/W2130066440","https://openalex.org/W2134812217","https://openalex.org/W2144634347","https://openalex.org/W2155512285","https://openalex.org/W2201725064","https://openalex.org/W2277781746","https://openalex.org/W2315327571","https://openalex.org/W2346496103"],"related_works":["https://openalex.org/W7095608149","https://openalex.org/W1910747976","https://openalex.org/W315748011","https://openalex.org/W2162974777","https://openalex.org/W2944082182","https://openalex.org/W2075552252","https://openalex.org/W2154291317","https://openalex.org/W2018493067","https://openalex.org/W1963795390","https://openalex.org/W1978537703"],"abstract_inverted_index":{"The":[0,126],"capacity":[1],"of":[2,18,32,75,82,110],"preexisting":[3],"antioxidant":[4,158],"pathways":[5],"to":[6,27,58,99,134,163],"handle":[7],"oxidative":[8,38,112],"stress":[9,21,39,113,117],"during":[10],"exercise":[11],"may":[12,154],"be":[13,135],"complemented":[14],"by":[15],"the":[16,30,108,146],"synthesis":[17],"inducible":[19,157],"heat":[20],"proteins":[22],"(HSP).":[23],"Our":[24],"purpose":[25],"was":[26,41,61,120,132],"determine":[28],"if":[29],"amount":[31],"mRNA":[33,56,115,131,148,153],"for":[34],"HSP32,":[35],"a":[36],"major":[37],"protein,":[40],"increased":[42,62],"in":[43,129,151,160],"muscle":[44,83,161,169],"after":[45,72,79,124],"repetitive":[46],"contractions.":[47,125,170],"Reverse":[48],"transcriptase-polymerase":[49],"chain":[50],"reaction":[51],"analysis":[52,92],"showed":[53],"that":[54,94],"HSP32":[55,130,152],"(normalized":[57],"alpha-actin":[59],"mRNA)":[60],"about":[63,66],"seven-":[64],"and":[65,78],"fourfold":[67],"(P":[68,104],"<":[69,105],"0.35)":[70],"immediately":[71],"1":[73],"h":[74,81,123],"exhaustive":[76],"running":[77],"3":[80],"contractions":[84],"(10":[85],"Hz":[86],"nerve":[87],"stimulation),":[88],"respectively.":[89],"Northern":[90],"blot":[91],"revealed":[93],"HSP70":[95],"mRNAs":[96],"were":[97],"3.5-":[98],"15.5-fold":[100],"above":[101],"control":[102],"value":[103],"0.05),":[106],"whereas":[107],"content":[109],"another":[111],"protein":[114,118],"(macrophage":[116],"23)":[119],"unchanged":[121],"0":[122],"relative":[127],"increase":[128,145],"found":[133],"dependent":[136],"on":[137],"active":[138],"tension":[139,142],"generation;":[140],"passive":[141],"did":[143],"not":[144],"HSP32-to-actin":[147],"ratio.":[149],"Increases":[150],"underlie":[155],"an":[156],"pathway":[159],"responsive":[162],"metabolic":[164],"stresses":[165],"associated":[166],"with":[167],"repeated":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}