{"id":"https://openalex.org/W240145192","doi":"https://doi.org/10.1182/blood.v37.6.647.647","title":"Neutrophiia-inducing Activity in Plasma of Neutropenic Human Beings","display_name":"Neutrophiia-inducing Activity in Plasma of Neutropenic Human Beings","publication_year":1971,"publication_date":"1971-06-01","ids":{"openalex":"https://openalex.org/W240145192","doi":"https://doi.org/10.1182/blood.v37.6.647.647","mag":"240145192","pmid":"https://pubmed.ncbi.nlm.nih.gov/5162310"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v37.6.647.647","doi":"https://doi.org/10.1182/blood.v37.6.647.647","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v37.6.647.647","pdf_url":"https://ashpublications.org/blood/article-pdf/37/6/647/576206/647.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/37/6/647/576206/647.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072709443","display_name":"John C. Marsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN C. MARSH","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, New Haven, Conn","Yale University School of Medicine, New Haven, Conn.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, New Haven, Conn","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Conn.;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088656909","display_name":"Martin Levitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARTIN LEVITT","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, New Haven, Conn","Yale University School of Medicine, New Haven, Conn.; formerly Fellow of The Leukemia Society of America","formerly Fellow of The Leukemia Society of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, New Haven, Conn","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University School of Medicine, New Haven, Conn.; formerly Fellow of The Leukemia Society of America","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"formerly Fellow of The Leukemia Society of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.4492,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.9151974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"6","first_page":"647","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-neutropenia","display_name":"drug-induced neutropenia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.824999988079071},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.5479999780654907},{"id":"https://openalex.org/keywords/plasma-transfusion","display_name":"plasma transfusion","score":0.6439999938011169},{"id":"https://openalex.org/keywords/humoral-factors","display_name":"humoral factors","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2777802486","wikidata":"https://www.wikidata.org/wiki/Q491741","display_name":"Neutrophilia","level":2,"score":0.9945768713951111},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.9115966558456421},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6964293122291565},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.6755133867263794},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.5960219502449036},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.5934003591537476},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5837389826774597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5232813954353333},{"id":"https://openalex.org/C2778527355","wikidata":"https://www.wikidata.org/wiki/Q5198214","display_name":"Cyclic neutropenia","level":4,"score":0.5025115013122559},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.46713733673095703},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.45349180698394775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4217199683189392},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3401486277580261},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3112761974334717},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1936764121055603}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001804","descriptor_name":"Blood Transfusion, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010956","descriptor_name":"Plasmapheresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011344","descriptor_name":"Procarbazine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v37.6.647.647","doi":"https://doi.org/10.1182/blood.v37.6.647.647","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v37.6.647.647","pdf_url":"https://ashpublications.org/blood/article-pdf/37/6/647/576206/647.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:5162310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5162310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v37.6.647.647","doi":"https://doi.org/10.1182/blood.v37.6.647.647","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v37.6.647.647","pdf_url":"https://ashpublications.org/blood/article-pdf/37/6/647/576206/647.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W240145192.pdf","grobid_xml":"https://content.openalex.org/works/W240145192.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W81640836","https://openalex.org/W116347685","https://openalex.org/W135606421","https://openalex.org/W140591857","https://openalex.org/W423748589","https://openalex.org/W1164360612","https://openalex.org/W1860632455","https://openalex.org/W1977359022","https://openalex.org/W1998974561","https://openalex.org/W2001407404","https://openalex.org/W2021330155","https://openalex.org/W2029249390","https://openalex.org/W2047839388","https://openalex.org/W2080172732","https://openalex.org/W2089137419","https://openalex.org/W2093600357","https://openalex.org/W2103202925","https://openalex.org/W2122535694","https://openalex.org/W2139770441","https://openalex.org/W2141643587","https://openalex.org/W2144674922","https://openalex.org/W2161029207","https://openalex.org/W2246121854","https://openalex.org/W2259393274","https://openalex.org/W2330432432","https://openalex.org/W2411308050","https://openalex.org/W2414105270","https://openalex.org/W2428120384","https://openalex.org/W2460102083","https://openalex.org/W2470362669"],"related_works":["https://openalex.org/W171338844","https://openalex.org/W1966992004","https://openalex.org/W1981821131","https://openalex.org/W2264828529","https://openalex.org/W1605555448","https://openalex.org/W2428120384","https://openalex.org/W6992174451","https://openalex.org/W1588482262","https://openalex.org/W140591857","https://openalex.org/W2055727873"],"abstract_inverted_index":{"Abstract":[0],"Humoral":[1],"factors":[2],"have":[3,23,144],"been":[4,25,34],"implicated":[5],"in":[6,13,16,27,36,111,120,165,168,184],"the":[7,37,51,65,75,81,87,95,99,112,121,125,136,149,169,186,196],"bone":[8,197],"marrow":[9,70],"release":[10,192],"of":[11,53,94,171,193],"neutrophils":[12,194],"experimental":[14],"animals":[15],"response":[17,39],"to":[18,40,80],"neutropenia.":[19],"No":[20],"comparable":[21],"studies":[22],"yet":[24],"reported":[26],"man,":[28],"although":[29],"a":[30,108,182],"humoral":[31],"mechanism":[32],"has":[33],"described":[35],"neutrophilic":[38],"endotoxin.":[41],"Three":[42],"patients":[43,101],"with":[44,102,107,124,151,158],"reversible":[45],"drug-induced":[46],"neutropenia":[47,60,104,154],"were":[48,73,78],"studied":[49],"for":[50],"presence":[52],"neutrophilia-inducing":[54,159],"activity":[55,162],"by":[56,190],"obtaining":[57],"plasma":[58,133,170],"during":[59],"and":[61,69,86,116,176],"after":[62,129],"recovery.":[63],"When":[64],"blood":[66,88,137,187],"neutrophil":[67,89,114,138,188],"concentration":[68,115,139,167,189],"granulocyte":[71],"reserves":[72],"normal,":[74],"paired":[76],"plasmas":[77,96],"returned":[79],"donors":[82],"on":[83],"different":[84],"days,":[85],"concentrations":[90],"sequentially":[91],"measured.":[92],"Reinfusion":[93],"obtained":[97,134],"from":[98,148,195],"two":[100],"marked":[103],"was":[105,140,155],"associated":[106,157],"2.5-3.5-fold":[109],"increase":[110,119],"total":[113],"an":[117],"8.5-fold":[118],"nonsegmented":[122],"neutrophils,":[123],"peak":[126],"30-60":[127],"min":[128],"infusion.":[130],"In":[131],"contrast,":[132],"when":[135],"normal":[141],"did":[142],"not":[143,156],"this":[145],"effect.":[146],"Plasma":[147],"patient":[150],"only":[152],"slight":[153],"activity.":[160],"Neutrophilia-inducing":[161],"is":[163],"present":[164],"increased":[166],"severely":[172],"neutropenic":[173],"human":[174],"beings":[175],"we":[177],"suggest":[178],"that":[179],"it":[180],"plays":[181],"role":[183],"regulating":[185],"causing":[191],"marrow.":[198]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
