{"id":"https://openalex.org/W2401448358","doi":null,"title":"Chemotherapy with mitomycin-C, epidoxorubicin and vinblastine in CMF failing breast cancer patients.","display_name":"Chemotherapy with mitomycin-C, epidoxorubicin and vinblastine in CMF failing breast cancer patients.","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W2401448358","mag":"2401448358","pmid":"https://pubmed.ncbi.nlm.nih.gov/2126683"},"language":"en","primary_location":{"id":"pmid:2126683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2126683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039478541","display_name":"Paolo Pronzato","orcid":"https://orcid.org/0000-0001-8203-2564","observed_orcids":["https://orcid.org/0000-0001-8203-2564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Pronzato","raw_affiliation_strings":["Department of Medical Oncology, Istituto Nazionale per la Riecerca sul Cancro, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Istituto Nazionale per la Riecerca sul Cancro, Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091084296","display_name":"DOMENICO AMOROSO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Amoroso","raw_affiliation_strings":["Istituto Nazionale per la Ricerca sul Cancro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per la Ricerca sul Cancro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027212039","display_name":"Gianfilippo Bertelli","orcid":"https://orcid.org/0000-0002-1798-0098","observed_orcids":["https://orcid.org/0000-0002-1798-0098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Bertelli","raw_affiliation_strings":["Istituto Nazionale per la Ricerca sul Cancro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per la Ricerca sul Cancro","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071929183","display_name":"Paola Queirolo","orcid":"https://orcid.org/0000-0002-9917-6633","observed_orcids":["https://orcid.org/0000-0002-9917-6633"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Queirolo","raw_affiliation_strings":["A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111567937","display_name":"M. R. Sertoli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Sertoli","raw_affiliation_strings":["Istituto Nazionale per la Ricerca sul Cancro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per la Ricerca sul Cancro","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062442517","display_name":"Renzo Rosso","orcid":"https://orcid.org/0000-0003-1062-1911","observed_orcids":["https://orcid.org/0000-0003-1062-1911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rosso","raw_affiliation_strings":["Istituto Nazionale per la Ricerca sul Cancro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per la Ricerca sul Cancro","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2128,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44879858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"6","first_page":"1743","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9190000295639038},{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.996999979019165},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/salvage-chemotherapy","display_name":"salvage chemotherapy","score":0.5389999747276306},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6320000290870667},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.901665210723877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8573602437973022},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6897437572479248},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6321783661842346},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6090119481086731},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5924568176269531},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.5807981491088867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5668684840202332},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.5394514203071594},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5069963932037354},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4293667674064636},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4271901845932007},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27757567167282104}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008937","descriptor_name":"Mitomycins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2126683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2126683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2401448358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2126683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966478765","https://openalex.org/W2022236680","https://openalex.org/W2015443376","https://openalex.org/W2414064437","https://openalex.org/W2411226111","https://openalex.org/W2409194634","https://openalex.org/W2262639695","https://openalex.org/W2408950811","https://openalex.org/W2080611112","https://openalex.org/W61371722"],"abstract_inverted_index":{"Since":[0],"most":[1],"patients":[2,47],"with":[3,8,20,48,59],"breast":[4,50],"cancer":[5],"are":[6,23],"treated":[7],"CMF":[9],"as":[10],"first":[11],"line":[12],"chemotherapy":[13],"(usually":[14],"in":[15,42],"the":[16,26],"adjuvant":[17],"setting),":[18],"schedules":[19],"alternative":[21],"drugs":[22],"needed":[24],"for":[25],"metastatic":[27,49],"disease.":[28],"In":[29],"this":[30],"study":[31],"a":[32,43,60],"new":[33],"combination":[34],"of":[35,45,55],"Mitomycin,":[36],"Epidoxorubicin":[37],"and":[38],"Vinblastine":[39],"was":[40,57],"employed":[41],"group":[44],"24":[46],"cancer.":[51],"A":[52],"response":[53],"rate":[54],"37.5%":[56],"observed":[58],"mild":[61],"to":[62],"moderate":[63],"toxicity.":[64]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}