{"id":"https://openalex.org/W2401424239","doi":"https://doi.org/10.1016/s1016-8478(23)25212-7","title":"Mapping of the Interaction Sites between Apoptosis Linked Gene ALG-2 and HEED","display_name":"Mapping of the Interaction Sites between Apoptosis Linked Gene ALG-2 and HEED","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2401424239","doi":"https://doi.org/10.1016/s1016-8478(23)25212-7","mag":"2401424239","pmid":"https://pubmed.ncbi.nlm.nih.gov/11804327"},"language":"en","primary_location":{"id":"doi:10.1016/s1016-8478(23)25212-7","doi":"https://doi.org/10.1016/s1016-8478(23)25212-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1016-8478(23)25212-7","pdf_url":null,"source":{"id":"https://openalex.org/S171170158","display_name":"Molecules and Cells","issn_l":"1016-8478","issn":["1016-8478","0219-1032"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules and Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s1016-8478(23)25212-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089416023","display_name":"Kyoung Hoa Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110118728","display_name":"Pai Chai University","ror":"https://ror.org/05drcjw53","country_code":"KR","type":"education","lineage":["https://openalex.org/I110118728"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyoung Hoa Lee","raw_affiliation_strings":["Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea","institution_ids":["https://openalex.org/I110118728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100339482","display_name":"Eunhee Kim","orcid":"https://orcid.org/0000-0002-7738-1222","observed_orcids":["https://orcid.org/0000-0002-7738-1222"]},"institutions":[{"id":"https://openalex.org/I110118728","display_name":"Pai Chai University","ror":"https://ror.org/05drcjw53","country_code":"KR","type":"education","lineage":["https://openalex.org/I110118728"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunhee Kim","raw_affiliation_strings":["Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea","institution_ids":["https://openalex.org/I110118728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649357","display_name":"Jong\u2010Soo Lee","orcid":"https://orcid.org/0000-0001-5119-0711","observed_orcids":["https://orcid.org/0000-0001-5119-0711"]},"institutions":[{"id":"https://openalex.org/I110118728","display_name":"Pai Chai University","ror":"https://ror.org/05drcjw53","country_code":"KR","type":"education","lineage":["https://openalex.org/I110118728"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Soo Lee","raw_affiliation_strings":["Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea","institution_ids":["https://openalex.org/I110118728"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008950749","display_name":"Ki\u2010Sung Lee","orcid":"https://orcid.org/0000-0001-7215-0639","observed_orcids":["https://orcid.org/0000-0001-7215-0639"]},"institutions":[{"id":"https://openalex.org/I110118728","display_name":"Pai Chai University","ror":"https://ror.org/05drcjw53","country_code":"KR","type":"education","lineage":["https://openalex.org/I110118728"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Sung Lee","raw_affiliation_strings":["Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea","institution_ids":["https://openalex.org/I110118728"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jung Woo Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110118728","display_name":"Pai Chai University","ror":"https://ror.org/05drcjw53","country_code":"KR","type":"education","lineage":["https://openalex.org/I110118728"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung Woo Kim","raw_affiliation_strings":["Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Med RRC and Division of Life Sciences, Pai Chai University, Taejon 302-735, Korea","institution_ids":["https://openalex.org/I110118728"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I110118728"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.1925,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.41103377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"12","issue":"3","first_page":"298","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alg-2","display_name":"ALG-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heed","display_name":"HEED","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.925000011920929},{"id":"https://openalex.org/keywords/ef-hand-motifs","display_name":"EF-hand motifs","score":0.722000002861023},{"id":"https://openalex.org/keywords/calcium-binding-proteins","display_name":"calcium-binding proteins","score":0.8370000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/wd-repeats","display_name":"WD repeats","score":0.6240000128746033},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.6959999799728394},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.7279999852180481},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8149999976158142},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7244280576705933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.599698543548584},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5535142421722412},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49807024002075195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4618280231952667},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.42223963141441345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3938664495944977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3884512782096863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24806872010231018}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1016-8478(23)25212-7","doi":"https://doi.org/10.1016/s1016-8478(23)25212-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1016-8478(23)25212-7","pdf_url":null,"source":{"id":"https://openalex.org/S171170158","display_name":"Molecules and Cells","issn_l":"1016-8478","issn":["1016-8478","0219-1032"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules and Cells","raw_type":"journal-article"},{"id":"pmid:11804327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11804327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules and cells","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1016-8478(23)25212-7","doi":"https://doi.org/10.1016/s1016-8478(23)25212-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1016-8478(23)25212-7","pdf_url":null,"source":{"id":"https://openalex.org/S171170158","display_name":"Molecules and Cells","issn_l":"1016-8478","issn":["1016-8478","0219-1032"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules and Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1469520329","https://openalex.org/W1512061023","https://openalex.org/W1538805645","https://openalex.org/W1569642404","https://openalex.org/W1910407513","https://openalex.org/W1965494729","https://openalex.org/W1972101413","https://openalex.org/W1973046803","https://openalex.org/W1981845572","https://openalex.org/W1986384364","https://openalex.org/W1986394736","https://openalex.org/W1987276980","https://openalex.org/W2025818427","https://openalex.org/W2028507130","https://openalex.org/W2041690382","https://openalex.org/W2046047615","https://openalex.org/W2057183992","https://openalex.org/W2162298614","https://openalex.org/W2165161047","https://openalex.org/W4390457351","https://openalex.org/W6634117205","https://openalex.org/W6656966048"],"related_works":["https://openalex.org/W1886753955","https://openalex.org/W2066093002","https://openalex.org/W1965494729","https://openalex.org/W2088625894","https://openalex.org/W784748220","https://openalex.org/W2009023024","https://openalex.org/W1981845572","https://openalex.org/W2147113077","https://openalex.org/W2053537100","https://openalex.org/W2094622652"],"abstract_inverted_index":{"The":[0,52,90],"apoptosis":[1,38],"linked":[2],"gene":[3],"(ALG-2)":[4],"is":[5,40,57,67],"a":[6,21,85,145],"22":[7],"kDa":[8],"Ca2+-binding":[9],"protein":[10],"of":[11,30,55,82,92,108,113,129,135,149],"the":[12,60,63,79,106,109,119,130,136,140,154],"penta":[13],"EF-hand":[14,147],"motif":[15,148],"family.":[16],"ALG-2":[17,31,35,56,75,114,150],"was":[18,151],"discovered":[19],"in":[20,69,125],"\"death":[22],"trap\"":[23],"assay":[24,88],"using":[25,32,84,133],"T-cell":[26],"receptor-mediated":[27],"apoptosis.":[28],"Depletion":[29],"an":[33],"anti-sense":[34],"construct":[36],"inhibits":[37],"that":[39,62,74,139],"induced":[41],"by":[42,96,103,117],"several":[43],"stimuli,":[44],"such":[45],"as":[46],"staurosporin,":[47],"dexamethason,":[48],"Fas,":[49],"and":[50,144],"glucocorticoid.":[51],"Ca2+-dependent":[53],"function":[54],"consistent":[58],"with":[59,78],"observation":[61],"cytoplasmic":[64],"Ca2+":[65,122],"level":[66],"elevated":[68],"apoptotic":[70],"cells.":[71],"We":[72],"found":[73],"interacted":[76],"specifically":[77],"carboxy-terminal":[80],"region":[81],"HEED":[83,93,143],"yeast":[86],"two-hybrid":[87],"system.":[89],"mutants":[91,112],"were":[94,115],"constructed":[95],"deleting":[97],"five":[98],"WD":[99],"repeat":[100],"motifs":[101,124],"one":[102,104],"from":[105],"C-terminus":[107],"protein.":[110],"These":[111],"made":[116],"combining":[118],"EF":[120],"hand":[121],"binding":[123],"various":[126],"ways.":[127],"Mapping":[128],"interaction":[131,141],"sites,":[132],"each":[134],"mutants,":[137],"revealed":[138],"between":[142],"third":[146],"stronger":[152],"than":[153],"other":[155],"combination.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}