{"id":"https://openalex.org/W2401398586","doi":null,"title":"L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice.","display_name":"L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice.","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2401398586","mag":"2401398586","pmid":"https://pubmed.ncbi.nlm.nih.gov/2963718","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542171"},"language":"en","primary_location":{"id":"pmid:2963718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2963718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1542171/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036116322","display_name":"G Kantwerk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Kantwerk","raw_affiliation_strings":["Diabetes-Research Institute, University of D\u00fcsseldorf, FRG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes-Research Institute, University of D\u00fcsseldorf, FRG","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011512891","display_name":"Stephen Paul Cobbold","orcid":"https://orcid.org/0000-0003-1206-4880","observed_orcids":["https://orcid.org/0000-0003-1206-4880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Cobbold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107461980","display_name":"Herman Waldmann","orcid":"https://orcid.org/0000-0001-7519-6720","observed_orcids":["https://orcid.org/0000-0001-7519-6720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Waldmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090127748","display_name":"Hubert Kolb","orcid":"https://orcid.org/0000-0003-0768-628X","observed_orcids":["https://orcid.org/0000-0003-0768-628X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kolb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8564,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.91408064,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"70","issue":"3","first_page":"585","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lyt-2-t-cells","display_name":"Lyt-2+ T cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd90","display_name":"CD90","score":0.6869999766349792},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7900000214576721},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.652999997138977},{"id":"https://openalex.org/keywords/islet-infiltration","display_name":"islet infiltration","score":0.6959999799728394},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8939999938011169},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/cytotoxic-suppressor-t-cells","display_name":"suppressor/cytotoxic T cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.5569999814033508},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pathogenesis-of-diabetes","display_name":"diabetes pathogenesis","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6294532418251038},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5671812891960144},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.541671633720398},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5188428163528442},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.4993603229522705},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.47607582807540894},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.44328221678733826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4427033066749573},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.4308200180530548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41118431091308594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4099140465259552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3713158369064331},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.32378482818603516},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0720173716545105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007518","descriptor_name":"Isoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2963718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2963718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1542171","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1542171/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"mag:2401398586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2963718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1542171","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1542171/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W256863010","https://openalex.org/W1964500611","https://openalex.org/W1990356591","https://openalex.org/W1990568245","https://openalex.org/W1995464415","https://openalex.org/W2007630137","https://openalex.org/W2009118138","https://openalex.org/W2025352682","https://openalex.org/W2026929713","https://openalex.org/W2068653310","https://openalex.org/W2070480282","https://openalex.org/W2092789457","https://openalex.org/W2133924734","https://openalex.org/W2150631622","https://openalex.org/W2151567849","https://openalex.org/W2404611980","https://openalex.org/W2434523719","https://openalex.org/W3036119513"],"related_works":["https://openalex.org/W2105327386","https://openalex.org/W2066689064","https://openalex.org/W2170628843","https://openalex.org/W2407455125","https://openalex.org/W1656371604","https://openalex.org/W2108891346","https://openalex.org/W1971425668","https://openalex.org/W2001712566","https://openalex.org/W2134897227","https://openalex.org/W2161433268"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,77,79,98],"determine":[3],"the":[4,12,37,72,83,88,106,129,186],"role":[5],"of":[6,14,29,74,85,87,105,117,131,137,174],"different":[7,190],"T":[8,39,45,52,60,90,108,123],"lymphocyte":[9],"subsets":[10,125],"in":[11,66,82,128,148,193],"pathogenesis":[13],"low-dose":[15],"streptozotocin":[16],"(LD-Sz)":[17],"induced":[18,133],"diabetes,":[19],"we":[20],"treated":[21],"mice":[22],"with":[23,26,34,101,152,155],"Sz":[24],"together":[25,151],"repeated":[27],"injections":[28],"rat":[30],"monoclonal":[31],"antibodies":[32],"(MoAb)":[33],"specificity":[35],"towards":[36],"mouse":[38],"cell":[40,91,109,124],"differentiation":[41],"markers":[42],"L3T4":[43,89,178],"('helper/inducer'":[44],"cells":[46,53,65,76,146,166,202],"and":[47,54,57,69,115,144,164,197],"some":[48],"macrophages),":[49],"Lyt-2":[50,180,201],"('cytotoxic/suppressor'":[51],"NK":[55],"cells)":[56],"Thy-1":[58],"(pan":[59],"lymphocytes).":[61],"Treatment":[62,100,154],"depleted":[63],"target":[64],"peripheral":[67],"blood":[68],"spleen;":[70],"decreased":[71],"ability":[73],"spleen":[75],"respond":[78],"mitogens;":[80],"and,":[81],"case":[84],"depletion":[86],"subset,":[92],"prevented":[93],"a":[94],"humoral":[95],"immune":[96],"response":[97],"SRBC.":[99],"MoAb":[102,156,175],"against":[103,176],"either":[104,177],"two":[107],"subtypes":[110],"could":[111],"protect":[112],"from":[113,191],"hyperglycaemia":[114],"loss":[116],"body":[118],"weight,":[119],"suggesting":[120],"that":[121,141,185,192],"both":[122,142,162],"were":[126],"implicated":[127],"development":[130,183],"LD-Sz":[132],"diabetes.":[134],"Immunocytochemical":[135],"analysis":[136],"pancreatic":[138],"sections":[139],"showed":[140],"L3T4+":[143,163],"Lyt-2+":[145,165],"participated":[147],"islet":[149,159],"infiltration":[150,160],"macrophages.":[153,170],"markedly":[157],"reduced":[158],"by":[161,169],"but":[167],"not":[168,204],"The":[171],"suppressive":[172],"effect":[173],"or":[179],"on":[181],"diabetes":[182],"suggests":[184],"pathomechanism":[187],"involved":[188],"is":[189],"experimental":[194],"autoimmune":[195],"neuritis":[196],"adjuvant":[198],"arthritis":[199],"where":[200],"are":[203],"involved.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}