{"id":"https://openalex.org/W2401205013","doi":null,"title":"Effect of split low dose total body irradiation on SFFV mRNA, genomic DNA and protein expression in mice infected with the Friend virus complex.","display_name":"Effect of split low dose total body irradiation on SFFV mRNA, genomic DNA and protein expression in mice infected with the Friend virus complex.","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2401205013","mag":"2401205013","pmid":"https://pubmed.ncbi.nlm.nih.gov/2013981"},"language":"en","primary_location":{"id":"pmid:2013981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2013981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108355273","display_name":"Rong Shen","orcid":"https://orcid.org/0000-0002-2620-1439","observed_orcids":["https://orcid.org/0000-0002-2620-1439"]},"institutions":[{"id":"https://openalex.org/I255400825","display_name":"Indiana University Hospital","ror":"https://ror.org/05rbkcx47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I255400825","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R N Shen","raw_affiliation_strings":["Department of Medicine Hematology/Oncology, Indiana University School of Medicine, Indianapolis 46202-5121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Hematology/Oncology, Indiana University School of Medicine, Indianapolis 46202-5121","institution_ids":["https://openalex.org/I255400825","https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Lu","raw_affiliation_strings":["Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109319762","display_name":"Maureen A. Harrington","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Harrington","raw_affiliation_strings":["Biochemistry & Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056525477","display_name":"Carolyn H. Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Srivastava","raw_affiliation_strings":["Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105002598","display_name":"Young June Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y J Kim","raw_affiliation_strings":["Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112137193","display_name":"Shang Zhen Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Z Zhou","raw_affiliation_strings":["Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103448870","display_name":"Bo Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Wu","raw_affiliation_strings":["Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111491871","display_name":"Sandra K. Ruscetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ruscetti","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E Broxmeyer","raw_affiliation_strings":["Microbiology & Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology & Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1737,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.51018237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3","first_page":"225","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/friend-virus-complex","display_name":"Friend virus complex","score":0.8090000152587891},{"id":"https://openalex.org/keywords/spleen-focus-forming-virus","display_name":"spleen focus-forming virus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/retrovirus-infection","display_name":"retroviral infection","score":0.8159999847412109},{"id":"https://openalex.org/keywords/low-dose-radiation","display_name":"low-dose radiation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/viral-mrna-expression","display_name":"viral mRNA expression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/envelope-glycoprotein","display_name":"envelope glycoprotein","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.8029999732971191},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.8545374274253845},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6995577812194824},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6779895424842834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6765608191490173},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6432750225067139},{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.5659892559051514},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5624821186065674},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.439473420381546},{"id":"https://openalex.org/C2779682186","wikidata":"https://www.wikidata.org/wiki/Q5504041","display_name":"Friend virus","level":3,"score":0.42291608452796936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35805797576904297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11506244540214539},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09203490614891052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012191","descriptor_name":"Retroviridae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012191","descriptor_name":"Retroviridae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D013155","descriptor_name":"Spleen Focus-Forming Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013155","descriptor_name":"Spleen Focus-Forming Viruses","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2013981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2013981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"mag:2401205013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2013981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1259371445","display_name":"REGULATION OF MYELOPOIESIS:  SUPPRESSOR FACTOR SYNERGISM","funder_award_id":"5r01ca036740-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1574480499","https://openalex.org/W2412018366","https://openalex.org/W2402459433","https://openalex.org/W2138727620","https://openalex.org/W1995693856","https://openalex.org/W1985098870","https://openalex.org/W2005284546","https://openalex.org/W4312064940","https://openalex.org/W2395688375","https://openalex.org/W2066366759"],"abstract_inverted_index":{"DBA/2":[0],"mice":[1,121,161,216],"infected":[2,120,188,199],"with":[3,27,123,163,204,217,223],"lethal":[4],"dosages":[5],"of":[6,30,97,109,208,226,231],"Friend":[7,111],"virus":[8,82,131],"complex":[9],"(FVC)":[10],"can":[11],"be":[12,148],"100%":[13],"cured":[14],"by":[15,37],"split-dose":[16],"total":[17],"body":[18],"irradiation":[19,74],"(TBI)":[20],"at":[21],"150":[22],"cGy,":[23],"an":[24],"effect":[25,46,96],"associated":[26,238],"the":[28,31,38,44,53,70,78,89,95,110,175,182,193,229],"restoration":[29],"cellular":[32],"immunity":[33],"which":[34,219],"is":[35,47],"compromised":[36],"virus.":[39,112],"The":[40],"exact":[41],"mechanism":[42],"underlying":[43],"curative":[45,124],"unknown,":[48],"but":[49,155,190],"it":[50],"may":[51],"involve":[52],"interferon":[54],"(IFN)":[55],"system":[56],"and":[57,106],"interleukin-2":[58],"(IL-2)":[59],"production.":[60],"Initial":[61],"studies":[62],"indicated":[63],"that":[64,73,117,141,174],"TBI":[65,102,196],"did":[66],"not":[67,156,191],"directly":[68],"inactivate":[69],"virus,":[71],"suggesting":[72],"either":[75],"acted":[76],"on":[77,85,103],"target":[79],"cells":[80,87,158,184,194],"for":[81],"replication":[83],"or":[84,165],"other":[86,236],"mediating":[88],"effect.":[90],"We":[91],"have":[92],"now":[93],"examined":[94],"this":[98,224],"relatively":[99],"low":[100,125],"dose":[101,126],"replication,":[104],"transcription,":[105],"protein":[107],"expression":[108],"Northern":[113],"blot":[114,138,171],"analysis":[115,139,172],"revealed":[116,140,173],"in":[118,150,157,166,181,192,215,235],"FVC":[119,187,198,218],"treated":[122,162,197,222],"TBI,":[127,164,227],"no":[128],"spleen":[129,153,168,183,211],"focus-forming":[130],"(SFFV)-specific":[132],"mRNA":[133],"species":[134],"were":[135],"detected.":[136],"Southern":[137],"a":[142],"6.0":[143],"kb":[144],"SFFV":[145,176],"fragment":[146],"could":[147],"detected":[149],"infected,":[151],"untreated":[152,186],"cells,":[154],"from":[159,185,195],"FVC-infected":[160],"uninfected":[167],"cells.":[169],"Western":[170],"envelope":[177],"glycoprotein":[178],"was":[179],"expressed":[180],"mice,":[189],"mice.":[200],"These":[201],"results,":[202],"consistent":[203],"our":[205],"previous":[206],"findings":[207],"greatly":[209],"reduced":[210],"focus":[212],"forming":[213],"units":[214],"had":[220],"been":[221],"regimen":[225],"suggest":[228],"possibility":[230],"using":[232],"such":[233],"treatments":[234],"retroviral":[237],"disorders.":[239]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
