{"id":"https://openalex.org/W2401129071","doi":"https://doi.org/10.1038/srep14875","title":"Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland","display_name":"Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland","publication_year":2015,"publication_date":"2015-10-08","ids":{"openalex":"https://openalex.org/W2401129071","doi":"https://doi.org/10.1038/srep14875","mag":"2401129071","pmid":"https://pubmed.ncbi.nlm.nih.gov/26445902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4597207"},"language":"en","primary_location":{"id":"doi:10.1038/srep14875","doi":"https://doi.org/10.1038/srep14875","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep14875","pdf_url":"https://www.nature.com/articles/srep14875.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep14875.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050860545","display_name":"Andrzej T. Slominski","orcid":"https://orcid.org/0000-0001-8963-3995","observed_orcids":["https://orcid.org/0000-0001-8963-3995"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrzej T. Slominski","raw_affiliation_strings":["Department of Dermatology, University of Alabama at Birmingham, AL, USA","VA Medical Center, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Alabama at Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"VA Medical Center, Birmingham, AL, USA","institution_ids":["https://openalex.org/I4210115616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053365826","display_name":"Tae\u2010Kang Kim","orcid":"https://orcid.org/0000-0003-1394-4134","observed_orcids":["https://orcid.org/0000-0003-1394-4134"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae-Kang Kim","raw_affiliation_strings":["Department of Dermatology, University of Alabama at Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Alabama at Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Departments of Pharmaceutical Sciences, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmaceutical Sciences, Memphis, TN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023973423","display_name":"Arnold E. Postlethwaite","orcid":"https://orcid.org/0000-0002-5952-0161","observed_orcids":["https://orcid.org/0000-0002-5952-0161"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold Postlethwaite","raw_affiliation_strings":["Medicine, University of Tennessee HSC, Memphis, TN, USA","VA Medical Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Tennessee HSC, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"VA Medical Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I4210086422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039870157","display_name":"Elaine W. Tieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elaine W. Tieu","raw_affiliation_strings":["School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029285544","display_name":"Edith K. Y. Tang","orcid":"https://orcid.org/0000-0002-6266-6874","observed_orcids":["https://orcid.org/0000-0002-6266-6874"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Edith K. Y. Tang","raw_affiliation_strings":["School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058359268","display_name":"Robert Charles Tuckey","orcid":"https://orcid.org/0000-0002-5022-4729","observed_orcids":["https://orcid.org/0000-0002-5022-4729"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert C. Tuckey","raw_affiliation_strings":["School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5050860545"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":16.4569,"has_fulltext":true,"cited_by_count":229,"citation_normalized_percentile":{"value":0.99673506,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"14875","last_page":"14875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp11a1","display_name":"CYP11A1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/secosteroids","display_name":"secosteroids","score":0.9269999861717224},{"id":"https://openalex.org/keywords/vitamin-d3-metabolism","display_name":"vitamin D3 metabolism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/7-dehydrocholesterol","display_name":"7-dehydrocholesterol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d3","display_name":"25-hydroxyvitamin D3","score":0.9309999942779541},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9829999804496765},{"id":"https://openalex.org/keywords/human-epidermis","display_name":"human epidermis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/serum","display_name":"serum","score":0.7429999709129333},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6807155013084412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6716907620429993},{"id":"https://openalex.org/C80446465","wikidata":"https://www.wikidata.org/wiki/Q412483","display_name":"Cholesterol side-chain cleavage enzyme","level":4,"score":0.6662510633468628},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6223333477973938},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.548081636428833},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4651798605918884},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4143725037574768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4110344648361206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40018677711486816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1850631833076477},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08245763182640076},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.05510404706001282},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002786","descriptor_name":"Cholesterol Side-Chain Cleavage Enzyme","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002786","descriptor_name":"Cholesterol Side-Chain Cleavage Enzyme","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002786","descriptor_name":"Cholesterol Side-Chain Cleavage Enzyme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003684","descriptor_name":"Dehydrocholesterols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003684","descriptor_name":"Dehydrocholesterols","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D003684","descriptor_name":"Dehydrocholesterols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012632","descriptor_name":"Secosteroids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012632","descriptor_name":"Secosteroids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012632","descriptor_name":"Secosteroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep14875","doi":"https://doi.org/10.1038/srep14875","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep14875","pdf_url":"https://www.nature.com/articles/srep14875.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4597207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4597207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:26445902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26445902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/bc4318ed-c7e5-4352-9525-dfc7f1dfd2ea","doi":null,"is_oa":true,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/bc4318ed-c7e5-4352-9525-dfc7f1dfd2ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Slominski, A T, Kim, T K, Li, W, Postlethwaite, A, Tieu, E, Tang, E & Tuckey, R 2015, 'Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland', Scientific Reports, vol. 5, pp. 14875. https://doi.org/10.1038/srep14875","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/srep14875","doi":"https://doi.org/10.1038/srep14875","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep14875","pdf_url":"https://www.nature.com/articles/srep14875.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3160014682","display_name":null,"funder_award_id":"1R21AR0666505-01A1","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3772672869","display_name":"Mechanism of action of 20-hydroxyvitamin D3 in dermal fibroblasts","funder_award_id":"R21AR066505","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4806036218","display_name":"Novel Biosynthethic Pathway for Secosteroids and the Skin","funder_award_id":"R01AR052190","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5034917867","display_name":"Discovery of tissue-selective, nonhypercalcemic VDR modulators for RA treatment","funder_award_id":"R21AR063242","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6503107640","display_name":"Acquisition of a Q-TOF Mass Spectrometer","funder_award_id":"1s10od010678-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6830852016","display_name":"Role of Exogenous Melatonin in Skin Biology","funder_award_id":"R01AR056666","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7434347083","display_name":"Acquisition of a 400MHz Solution NMR System with an Autosampler","funder_award_id":"S10RR026377","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2401129071.pdf","grobid_xml":"https://content.openalex.org/works/W2401129071.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W7699552","https://openalex.org/W1495372639","https://openalex.org/W1507465276","https://openalex.org/W1548020831","https://openalex.org/W1563558118","https://openalex.org/W1572825508","https://openalex.org/W1837567610","https://openalex.org/W1887054657","https://openalex.org/W1965916393","https://openalex.org/W1966414524","https://openalex.org/W1966916284","https://openalex.org/W1968274590","https://openalex.org/W1972743589","https://openalex.org/W1976466424","https://openalex.org/W1977233186","https://openalex.org/W1978537670","https://openalex.org/W1982421644","https://openalex.org/W1994942125","https://openalex.org/W1995138037","https://openalex.org/W1995315750","https://openalex.org/W2000227232","https://openalex.org/W2005891610","https://openalex.org/W2009171847","https://openalex.org/W2010930504","https://openalex.org/W2011216582","https://openalex.org/W2011645313","https://openalex.org/W2017458967","https://openalex.org/W2018517476","https://openalex.org/W2020048876","https://openalex.org/W2020736043","https://openalex.org/W2021636579","https://openalex.org/W2024440231","https://openalex.org/W2027278752","https://openalex.org/W2028875889","https://openalex.org/W2036051073","https://openalex.org/W2040722453","https://openalex.org/W2049495450","https://openalex.org/W2057906330","https://openalex.org/W2066368067","https://openalex.org/W2071882832","https://openalex.org/W2073924296","https://openalex.org/W2074330545","https://openalex.org/W2076615170","https://openalex.org/W2082168591","https://openalex.org/W2083203284","https://openalex.org/W2083444816","https://openalex.org/W2092970630","https://openalex.org/W2095263334","https://openalex.org/W2108296645","https://openalex.org/W2113779902","https://openalex.org/W2118889444","https://openalex.org/W2121341879","https://openalex.org/W2122456263","https://openalex.org/W2122507575","https://openalex.org/W2122908584","https://openalex.org/W2124070987","https://openalex.org/W2127898028","https://openalex.org/W2127919481","https://openalex.org/W2157471721","https://openalex.org/W2157698829","https://openalex.org/W2158555665","https://openalex.org/W2165780256"],"related_works":["https://openalex.org/W1995138037","https://openalex.org/W1976466424","https://openalex.org/W2028875889","https://openalex.org/W2158555665","https://openalex.org/W2891847712","https://openalex.org/W4388317459","https://openalex.org/W2020431823","https://openalex.org/W3157760762","https://openalex.org/W3033620179","https://openalex.org/W4308133246"],"abstract_inverted_index":{"To":[0],"investigate":[1],"whether":[2],"novel":[3,173],"pathways":[4],"of":[5,27,38,42,85,113,150],"vitamin":[6],"D3":[7,86],"(D3)":[8],"and":[9,16,30,32,40,52,57,75,79,100,115,120,126,144,158,166,180,183,188],"7-dehydrocholesterol":[10],"(7DHC)":[11],"metabolism":[12],"initiated":[13],"by":[14,60],"CYP11A1":[15,151],"previously":[17],"characterized":[18],"in":[19,22,108,137,146,163,176,197],"vitro,":[20],"occur":[21],"vivo,":[23],"we":[24,170],"analyzed":[25,58,71],"samples":[26,81],"human":[28,47],"serum":[29,78,179],"epidermis,":[31],"pig":[33],"adrenals":[34],"for":[35,72,132],"the":[36,63,83,109,147,167,177],"presence":[37,84],"intermediates":[39],"products":[41],"these":[43,73],"pathways.":[44],"We":[45,139],"extracted":[46],"epidermis":[48,165],"from":[49,54],"13":[50,55],"individuals":[51,56],"sera":[53],"them":[59],"LC/qTOF-MS":[61],"alongside":[62],"corresponding":[64,88],"standards.":[65],"Pig":[66],"adrenal":[67,80,181],"glands":[68],"were":[69,117,160],"also":[70,140,161],"steroids":[74],"secosteroids.":[76],"Epidermal,":[77],"showed":[82],"hydroxy-derivatives":[87],"to":[89],"20(OH)D3,":[90],"22(OH)D3,":[91],"25(OH)D3,":[92,124],"1,25(OH)2D3,":[93],"20,22(OH)2D3,":[94],"20,23(OH)2D3,":[95],"20,24(OH)2D3,":[96],"20,25(OH)2D3,":[97],"20,26(OH)2D3,":[98],"1,20,23(OH)3D3":[99],"17,20,23(OH)3D3,":[101],"plus":[102],"1,20(OH)2D3":[103],"which":[104],"was":[105],"detectable":[106],"only":[107,118],"epidermis.":[110],"Serum":[111],"concentrations":[112,187],"20(OH)D3":[114],"22(OH)D3":[116],"30-":[119],"15-fold":[121],"lower":[122],"than":[123],"respectively,":[125],"at":[127],"levels":[128],"above":[129],"those":[130],"required":[131],"biological":[133,189],"activity":[134,190],"as":[135,195],"measured":[136],"vitro.":[138],"detected":[141,162,172],"1,20,24(OH)3D3,":[142],"1,20,25(OH)3D3":[143],"1,20,26(OH)3D3":[145],"adrenals.":[148],"Products":[149],"action":[152],"on":[153,185],"7DHC,":[154],"namely":[155],"22(OH)7DHC,":[156],"20,22(OH)27DHC":[157],"7-dehydropregnenolone":[159],"serum,":[164],"adrenal.":[168],"Thus,":[169],"have":[171],"CYP11A1-derived":[174],"secosteroids":[175],"skin,":[178],"gland":[182],"based":[184],"their":[186],"suggest":[191],"that":[192],"they":[193],"act":[194],"hormones":[196],"vivo.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
