{"id":"https://openalex.org/W2401068537","doi":null,"title":"Convergent signalling in the action of integrins, neuropeptides, growth factors and oncogenes.","display_name":"Convergent signalling in the action of integrins, neuropeptides, growth factors and oncogenes.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2401068537","mag":"2401068537","pmid":"https://pubmed.ncbi.nlm.nih.gov/7553664"},"language":"en","primary_location":{"id":"pmid:7553664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7553664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer surveys","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077935609","display_name":"Enrique Rozengurt","orcid":"https://orcid.org/0000-0002-7838-9170","observed_orcids":["https://orcid.org/0000-0002-7838-9170"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E Rozengurt","raw_affiliation_strings":["Growth Regulation Laboratory, Imperial Cancer Research Fund, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth Regulation Laboratory, Imperial Cancer Research Fund, London","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077935609"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2398,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.95035029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":null,"first_page":"81","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.5070000290870667},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.7760000228881836},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pp60src","display_name":"pp60src","score":0.7269999980926514},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.765999972820282},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/paxillin","display_name":"paxillin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bombesin","display_name":"bombesin","score":0.7170000076293945},{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.9629999995231628},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7419999837875366},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.9269999861717224},{"id":"https://openalex.org/keywords/signal-convergence","display_name":"signal convergence","score":0.5260000228881836},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.7950068712234497},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6565176248550415},{"id":"https://openalex.org/C116581196","wikidata":"https://www.wikidata.org/wiki/Q14906591","display_name":"Paxillin","level":4,"score":0.6485221982002258},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6317360401153564},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6252282857894897},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5462628602981567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5175711512565613},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.497513085603714},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4837951362133026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24057400226593018},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16779249906539917}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051419","descriptor_name":"Paxillin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7553664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7553664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer surveys","raw_type":"Journal Article"},{"id":"mag:2401068537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7553664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2396282355","https://openalex.org/W2051942264","https://openalex.org/W1981462495","https://openalex.org/W2331046032","https://openalex.org/W1549544590","https://openalex.org/W2172014045","https://openalex.org/W4300662607","https://openalex.org/W1543594980","https://openalex.org/W2043117244","https://openalex.org/W2409743628"],"abstract_inverted_index":{"These":[0],"findings":[1],"have":[2],"important":[3,338],"implications":[4],"for":[5,69,134,340,367],"signal":[6,52,299],"transduction":[7,53,143,300],"and":[8,42,102,118,151,155,180,202,208,215,231,245,248,267,290,316,328],"cell":[9,148,153,156,335,372],"regulation.":[10,373],"Most":[11],"obviously,":[12],"they":[13],"suggest":[14],"that":[15,50,99,146,237],"tyrosine":[16,23,87,190,211,238,317,326],"phosphorylation":[17,88,111,171,191,212,239,252,327],"of":[18,22,29,34,38,60,74,86,110,123,144,165,175,213,240,272,293,296,332,344,347],"a":[19,27,107,132,138,197,218],"novel":[20],"type":[21],"kinase":[24,318],"p125FAK":[25,124,170,189,214,241,297,325,333],"is":[26,49,76,95,128,235],"point":[28,140],"convergence":[30,75],"in":[31,65,82,106,141,160,274,281,298,334,357,371],"the":[32,51,79,83,142,173,251,270,294,304,329,345],"action":[33],"integrins,":[35,115],"oncogenic":[36],"forms":[37],"pp60src,":[39],"mitogenic":[40,116],"neuropeptides":[41,117,268],"growth":[43,119],"factors":[44],"(Fig.":[45],"3).":[46],"One":[47],"inference":[48],"pathways":[54,167],"initiated":[55],"by":[56,78,114,196,242,254,307],"these":[57,91],"diverse":[58],"groups":[59],"molecules":[61],"have,":[62],"at":[63],"least":[64],"part,":[66],"similar":[67],"consequences":[68],"cellular":[70,291],"function.":[71],"The":[72,121,163],"notion":[73],"reinforced":[77],"striking":[80],"similarity":[81],"overall":[84],"pattern":[85],"produced":[89],"through":[90,217],"different":[92,309],"pathways.":[93],"It":[94,234],"tempting":[96],"to":[97,125,169,193,263,324,355],"speculate":[98],"p125FAK,":[100,275,348],"paxillin":[101,216],"p130":[103],"are":[104,337,353],"components":[105],"common":[108],"programme":[109],"events":[112],"stimulated":[113],"factors.":[120],"localization":[122,352],"focal":[126,362],"adhesions":[127],"clearly":[129],"consistent":[130],"with":[131,361],"role":[133,295,331,370],"this":[135],"protein":[136,182],"as":[137,158,276],"junction":[139],"signals":[145,322],"regulate":[147],"substrate":[149],"adhesion":[150],"ultimately":[152],"motility":[154],"shape,":[157],"suggested":[159],"Fig.":[161],"3.":[162],"existence":[164],"distinct":[166],"leading":[168,323],"raises":[172],"possibility":[174],"synergistic":[176],"interactions":[177],"between":[178],"integrins":[179,266],"G":[181],"coupled":[183],"receptors.":[184],"In":[185],"fact,":[186],"integrin":[187,255],"mediated":[188,195],"appears":[192],"be":[194,261,359,365],"PKC":[198,219],"dependent":[199],"pathway":[200,221],"(Vuori":[201],"Ruoslathi,":[203],"1993).":[204],"By":[205],"contrast,":[206],"bombesin":[207],"LPA":[209,244],"induce":[210],"independent":[220],"(Sinnett-Smith":[222],"et":[223,227,285],"al,":[224,228,286],"1993;":[225,229],"Zachary":[226],"Seufferlein":[230],"Rozengurt,":[232],"1994).":[233,287],"possible":[236],"bombesin,":[243],"pp60v-src":[246],"bypasses":[247],"perhaps":[249],"mimics":[250],"caused":[253],"activation.":[256],"Further":[257],"experimental":[258],"work":[259],"will":[260,364],"required":[262],"elucidate":[264],"whether":[265],"increase":[269],"autophosphorylation":[271],"Tyr-397":[273],"has":[277],"been":[278],"recently":[279],"demonstrated":[280],"src-transformed":[282],"cells":[283],"(Schaller":[284],"Thus,":[288],"molecular":[289,305],"aspects":[292],"remain":[301],"unclear.":[302],"Specifically,":[303],"steps":[306],"which":[308,349],"receptors":[310,315],"(integrins,":[311],"seven":[312],"transmembrane":[313],"domain":[314],"receptors)":[319],"can":[320],"transduce":[321],"precise":[330],"regulation":[336],"areas":[339],"further":[341],"research.":[342],"Identification":[343],"substrates":[346],"given":[350],"its":[351,369],"likely":[354],"reside":[356],"or":[358],"associated":[360],"adhesion,":[363],"crucial":[366],"elucidating":[368]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}