{"id":"https://openalex.org/W2400993640","doi":null,"title":"in vivo synergistic cytotoxicity in multiple myeloma Combination of proteasome inhibitors bortezomib and NPI-0052 trigger","display_name":"in vivo synergistic cytotoxicity in multiple myeloma Combination of proteasome inhibitors bortezomib and NPI-0052 trigger","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2400993640","mag":"2400993640"},"language":"en","primary_location":{"id":"mag:2400993640","doi":null,"is_oa":false,"landing_page_url":"http://triphaseco.com/wp-content/uploads/2014/08/Chauhan-et-al-0052-Velcade-Combo-Blood-2008_lt.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7344-9795","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000260833","display_name":"Michael A. Palladino","orcid":"https://orcid.org/0000-0002-4687-7612","observed_orcids":["https://orcid.org/0000-0002-4687-7612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Palladino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4687-7612","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth C. Anderson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6418-0886","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006765393","display_name":"Dharminder Chauhan","orcid":"https://orcid.org/0000-0002-5548-6138","observed_orcids":["https://orcid.org/0000-0002-5548-6138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dharminder Chauhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102256659","display_name":"Ajita Singh","orcid":"https://orcid.org/0000-0002-6070-4232","observed_orcids":["https://orcid.org/0000-0002-6070-4232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajita Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046386191","display_name":"Mohan Brahmandam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohan Brahmandam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007023688","display_name":"Klaus Podar","orcid":"https://orcid.org/0000-0002-7414-3632","observed_orcids":["https://orcid.org/0000-0002-7414-3632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus Podar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7414-3632","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091207345","display_name":"Teru Hideshima","orcid":"https://orcid.org/0000-0003-2939-6224","observed_orcids":["https://orcid.org/0000-0003-2939-6224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teru Hideshima","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2939-6224","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31442587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9399999976158142},{"id":"https://openalex.org/keywords/npi-0052","display_name":"NPI-0052","score":0.9929999709129333},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.906000018119812},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.9315926432609558},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.8560965061187744},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7884626388549805},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7352299094200134},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6888673305511475},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.579893946647644},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46955496072769165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44289132952690125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3772525191307068},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3539019227027893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3378050923347473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3189239501953125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1647927165031433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12647497653961182},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2400993640","doi":null,"is_oa":false,"landing_page_url":"http://triphaseco.com/wp-content/uploads/2014/08/Chauhan-et-al-0052-Velcade-Combo-Blood-2008_lt.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1513849811","https://openalex.org/W1518640128","https://openalex.org/W1520422891","https://openalex.org/W1573531091","https://openalex.org/W1589662393","https://openalex.org/W1590553747","https://openalex.org/W1607209090","https://openalex.org/W1646203193","https://openalex.org/W1759028523","https://openalex.org/W1761234319","https://openalex.org/W1904784968","https://openalex.org/W1935443268","https://openalex.org/W1963689482","https://openalex.org/W1968229731","https://openalex.org/W1969158591","https://openalex.org/W1969894269","https://openalex.org/W1980471295","https://openalex.org/W1984998337","https://openalex.org/W1985632417","https://openalex.org/W1987583882","https://openalex.org/W1992978957","https://openalex.org/W1995596496","https://openalex.org/W2000246028","https://openalex.org/W2010039708","https://openalex.org/W2020738975","https://openalex.org/W2021242983","https://openalex.org/W2023687151","https://openalex.org/W2026642838","https://openalex.org/W2034941135","https://openalex.org/W2038012199","https://openalex.org/W2039278049","https://openalex.org/W2043049816","https://openalex.org/W2043943641","https://openalex.org/W2049743082","https://openalex.org/W2067653691","https://openalex.org/W2068696470","https://openalex.org/W2076710136","https://openalex.org/W2077945404","https://openalex.org/W2087092058","https://openalex.org/W2091823485","https://openalex.org/W2100608938","https://openalex.org/W2101577478","https://openalex.org/W2106906885","https://openalex.org/W2108235071","https://openalex.org/W2118820477","https://openalex.org/W2120590293","https://openalex.org/W2124560610","https://openalex.org/W2126267349","https://openalex.org/W2126885291","https://openalex.org/W2129752729","https://openalex.org/W2132485651","https://openalex.org/W2138102966","https://openalex.org/W2140182533","https://openalex.org/W2143938165","https://openalex.org/W2145412346","https://openalex.org/W2147576659","https://openalex.org/W2148537814","https://openalex.org/W2151191257","https://openalex.org/W2154374454","https://openalex.org/W2158714866","https://openalex.org/W2159679541","https://openalex.org/W2162537424","https://openalex.org/W2163679078","https://openalex.org/W2166987747","https://openalex.org/W2171513236","https://openalex.org/W2292093022","https://openalex.org/W2339661511"],"related_works":["https://openalex.org/W7096145386","https://openalex.org/W2010184965","https://openalex.org/W2560359838","https://openalex.org/W1987583882","https://openalex.org/W1968882794","https://openalex.org/W2007644267","https://openalex.org/W2588338482","https://openalex.org/W2243792761","https://openalex.org/W2910942915","https://openalex.org/W7098059288"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
