{"id":"https://openalex.org/W2400979752","doi":null,"title":"The interaction of a lung surfactant protein (SP-A) with macrophages is mannose dependent.","display_name":"The interaction of a lung surfactant protein (SP-A) with macrophages is mannose dependent.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2400979752","mag":"2400979752","pmid":"https://pubmed.ncbi.nlm.nih.gov/2627938"},"language":"en","primary_location":{"id":"pmid:2627938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2627938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111840171","display_name":"Eva Sabine Wintergerst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Wintergerst","raw_affiliation_strings":["Faculty of Biology, University of Konstanz, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, University of Konstanz, Federal Republic of Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023991455","display_name":"Heiderose Manz-Keinke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Manz-Keinke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014561175","display_name":"Helmut Plattner","orcid":"https://orcid.org/0000-0002-2594-5591","observed_orcids":["https://orcid.org/0000-0002-2594-5591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Plattner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037968999","display_name":"Jutta Schlepper\u2010Sch\u00e4fer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Schlepper-Sch\u00e4fer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6461,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.66330563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"50","issue":"2","first_page":"291","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.1251000016927719,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.10000000149011612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surfactant-protein-a","display_name":"surfactant protein A","score":0.949999988079071},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.6370000243186951},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8339999914169312},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.859000027179718},{"id":"https://openalex.org/keywords/receptor-mediated-uptake","display_name":"receptor-mediated uptake","score":0.5830000042915344},{"id":"https://openalex.org/keywords/lysosome-trafficking","display_name":"lysosomal trafficking","score":0.6510000228881836},{"id":"https://openalex.org/keywords/lectin-binding","display_name":"lectin binding","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.7620000243186951},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/mannose-specific-lectin","display_name":"mannose-specific lectin","score":0.5989999771118164},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.8521904945373535},{"id":"https://openalex.org/C2776205754","wikidata":"https://www.wikidata.org/wiki/Q6750945","display_name":"Mannose receptor","level":4,"score":0.7773518562316895},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.70451420545578},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.6719744205474854},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.5894595384597778},{"id":"https://openalex.org/C189413060","wikidata":"https://www.wikidata.org/wiki/Q415443","display_name":"Mannan-binding lectin","level":3,"score":0.5261701345443726},{"id":"https://openalex.org/C133493029","wikidata":"https://www.wikidata.org/wiki/Q83167205","display_name":"Collectin","level":4,"score":0.5252282619476318},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5058150291442871},{"id":"https://openalex.org/C2779719659","wikidata":"https://www.wikidata.org/wiki/Q24577942","display_name":"Mannan","level":3,"score":0.5054416656494141},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4889470338821411},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.48427337408065796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4800789952278137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47304481267929077},{"id":"https://openalex.org/C2777438239","wikidata":"https://www.wikidata.org/wiki/Q14914144","display_name":"Surfactant protein D","level":4,"score":0.4515473246574402},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4294658303260803},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.4268140494823456},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.42339378595352173},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4227503836154938},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.39997437596321106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3188750743865967},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31606099009513855},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.2115950882434845},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.1259208619594574},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.11787709593772888},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08779111504554749},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.06850114464759827},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011510","descriptor_name":"Proteolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037661","descriptor_name":"Pulmonary Surfactant-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037662","descriptor_name":"Pulmonary Surfactant-Associated Protein A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2627938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2627938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cell biology","raw_type":"Journal Article"},{"id":"mag:2400979752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2627938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999901481","https://openalex.org/W1978234254","https://openalex.org/W2127139092","https://openalex.org/W2189003912","https://openalex.org/W2122445785","https://openalex.org/W2139848686","https://openalex.org/W2468617660","https://openalex.org/W2436813716","https://openalex.org/W2411927488","https://openalex.org/W2326090463"],"abstract_inverted_index":{"Lung":[0],"surfactant":[1],"protein":[2,8],"A":[3,150],"(SP-A)":[4],"is":[5,90,111],"the":[6,15,20,66,103,123,129,188,193],"main":[7],"component":[9],"of":[10,34,68,128,195],"pulmonary":[11],"surfactant,":[12],"which":[13],"lines":[14],"alveolar":[16],"space.":[17],"We":[18],"examined":[19],"interaction":[21],"between":[22],"recombinant":[23],"human":[24,27],"SP-A":[25,35,50,83,89,110,176,196],"and":[26,32,46,57],"macrophages":[28,132,145],"or":[29],"monocytes.":[30],"Binding":[31],"uptake":[33,84],"adsorbed":[36,151],"onto":[37,138,152],"colloidal":[38],"gold":[39,139,153,177],"particles":[40,51,178],"was":[41,63,133],"followed":[42],"by":[43,75,85,148,197],"electron":[44],"microscopy":[45],"quantitated":[47],"on":[48,106,122,131,144,170],"micrographs.":[49],"were":[52,146],"internalized":[53],"via":[54],"coated":[55,137],"pits/vesicles":[56],"transported":[58],"to":[59,119],"secondary":[60],"lysosomes.":[61],"Uptake":[62],"inhibited":[64],"in":[65,161,179,192],"presence":[67],"alpha-D-mannosyl-bovine":[69],"serum":[70],"albumin":[71],"(BSA)":[72],"but":[73,174],"not":[74],"beta-D-galactosyl-BSA.":[76],"Two":[77],"mannose-dependent":[78,181],"recognition":[79,194],"mechanisms":[80,157],"might":[81],"mediate":[82],"macrophages.":[86,107,198],"First,":[87],"as":[88,99,109],"a":[91,100,112,180],"glycoprotein":[92],"with":[93,135],"N-glycosylated":[94],"glycans":[95],"it":[96,116],"could":[97,117],"act":[98],"ligand":[101],"for":[102],"mannose-specific":[104,113,167],"receptor":[105,168],"Second,":[108],"lectin":[114],"itself":[115],"bind":[118],"mannose":[120],"residues":[121,143],"macrophage's":[124],"cell":[125,172],"surface.":[126],"Activity":[127],"Man-receptor":[130],"demonstrated":[134],"alpha-D-mannosyl-BSA":[136],"particles.":[140,154],"Exposed":[141],"alpha-D-mannosyl":[142],"identified":[147],"Concanavalin":[149],"Hence,":[155],"both":[156],"may":[158],"be":[159],"involved":[160],"principle.":[162],"As":[163],"monocytes":[164],"have":[165],"no":[166],"activity":[169],"their":[171],"surface":[173],"internalize":[175],"manner,":[182],"we":[183],"conclude":[184],"that":[185],"at":[186],"least":[187],"second":[189],"mechanism":[190],"participates":[191]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
