{"id":"https://openalex.org/W24009679","doi":"https://doi.org/10.1096/fasebj.21.6.a1001-d","title":"Targeted Therapeutic Peptide Delivery to Synaptic Junctions as Botulism Countermeasure","display_name":"Targeted Therapeutic Peptide Delivery to Synaptic Junctions as Botulism Countermeasure","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W24009679","doi":"https://doi.org/10.1096/fasebj.21.6.a1001-d","mag":"24009679"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1001-d","doi":"https://doi.org/10.1096/fasebj.21.6.a1001-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1001-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100364045","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0001-8071-3729","observed_orcids":["https://orcid.org/0000-0001-8071-3729","https://orcid.org/0009-0000-6200-2093"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["ET, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ET, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380702","display_name":"Dan Li","orcid":"https://orcid.org/0000-0002-1609-1539","observed_orcids":["https://orcid.org/0000-0002-1609-1539"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["ET, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ET, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110177713","display_name":"Radharaman Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radharaman Ray","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083903249","display_name":"Bal Ram Singh","orcid":"https://orcid.org/0000-0002-9069-1487","observed_orcids":["https://orcid.org/0000-0002-9069-1487"]},"institutions":[{"id":"https://openalex.org/I100633361","display_name":"University of Massachusetts Dartmouth","ror":"https://ror.org/00fzmm222","country_code":"US","type":"education","lineage":["https://openalex.org/I100633361"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bal Ram Singh","raw_affiliation_strings":["Chemistry and Biochemistry, University of Massachusetts, 285 Old Westport Rd, Dartmouth, MA, 02747"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry, University of Massachusetts, 285 Old Westport Rd, Dartmouth, MA, 02747","institution_ids":["https://openalex.org/I100633361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035687312","display_name":"James E. Keller","orcid":"https://orcid.org/0000-0001-5432-8421","observed_orcids":["https://orcid.org/0000-0001-5432-8421"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E Keller","raw_affiliation_strings":["U. S. Food and Drug Administration, 9000 Rockville Pike, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U. S. Food and Drug Administration, 9000 Rockville Pike, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002108565","display_name":"Michael Adler","orcid":"https://orcid.org/0000-0002-0999-3681","observed_orcids":["https://orcid.org/0000-0002-0999-3681"]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Adler","raw_affiliation_strings":["United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010","institution_ids":["https://openalex.org/I4210088792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109496315","display_name":"Prabhati Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prabhati Ray","raw_affiliation_strings":["ET, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ET, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00298665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin","display_name":"botulinum toxin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/synapses","display_name":"synapses","score":0.6650000214576721},{"id":"https://openalex.org/keywords/neuronal-uptake","display_name":"neuronal uptake","score":0.6010000109672546},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.8140000104904175},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/spinal-neurons","display_name":"spinal cord neurons","score":0.9010000228881836},{"id":"https://openalex.org/keywords/intracellular-drug-delivery","display_name":"intracellular drug delivery","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7032643556594849},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.52972811460495},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.525157630443573},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49192047119140625},{"id":"https://openalex.org/C2779186577","wikidata":"https://www.wikidata.org/wiki/Q154865","display_name":"Botulism","level":2,"score":0.46775031089782715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44736623764038086},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.4226084351539612},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3732951283454895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28062331676483154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16072538495063782},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1577087640762329},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1001-d","doi":"https://doi.org/10.1096/fasebj.21.6.a1001-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1001-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1534768742","https://openalex.org/W2041590478","https://openalex.org/W2081575107","https://openalex.org/W2589583594","https://openalex.org/W2294449531","https://openalex.org/W4245632656","https://openalex.org/W2013648695","https://openalex.org/W1975768169","https://openalex.org/W3120061304","https://openalex.org/W2113310136"],"abstract_inverted_index":{"Development":[0],"of":[1,29,36,46,79,108,123,142,172,184],"an":[2,12,51],"effective":[3],"medical":[4],"countermeasure":[5],"strategy":[6],"against":[7],"botulinum":[8],"neurotoxin":[9],"(BoNT)":[10],"is":[11],"urgent":[13],"military":[14],"mission.":[15],"In":[16,164],"this":[17],"study,":[18],"a":[19,57,199],"targeted":[20],"delivery":[21],"vehicle":[22],"(DV)":[23],"was":[24,66,82,111,126,136,147,156],"developed":[25],"for":[26],"intracellular":[27],"transport":[28],"emerging":[30],"BoNT":[31],"antagonists.":[32],"The":[33,63,106,120,189],"DV":[34,80,87,92,103,109,118,124,155,174,190],"consisted":[35],"Cy3-labeled":[37],"recombinant":[38],"BoNT/A":[39],"heavy":[40],"chain":[41],"(rHC),":[42],"which":[43,89],"promotes":[44],"internalization":[45],"the":[47,75,102,132,139,150,162,170,173,182],"complex,":[48],"coupled":[49],"to":[50,59,161],"OG":[52],"488-labeled":[53],"dextran":[54,153],"served":[55],"as":[56,198],"platform":[58],"deliver":[60],"therapeutic":[61],"molecules.":[62],"neuronal":[64,185],"model":[65,200],"cultured":[67],"mouse":[68],"spinal":[69],"cord":[70],"neurons.":[71],"Our":[72],"results":[73,167],"indicated":[74],"following:":[76],"no":[77],"separation":[78,107,121,134,171],"components":[81,93,110,125,175],"observed":[83,112,137],"in":[84,113,149,154,193,203],"1":[85],"hour":[86],"treatment,":[88],"suggests":[90],"that":[91,169],"inside":[94,176],"neurons":[95,177],"may":[96,178,196],"not":[97],"be":[98,179],"separated":[99],"immediately":[100],"after":[101,128],"complex":[104],"uptake;":[105],"12":[114],"and":[115,152],"24":[116],"hours":[117],"treatments.":[119],"rate":[122,135],"increased":[127],"prolonged":[129],"culture":[130],"periods,":[131],"highest":[133],"during":[138],"3rd":[140],"week":[141],"culture;":[143],"all":[144],"rHC":[145],"uptake":[146],"localized":[148],"endosomes":[151,160],"partially":[157],"released":[158],"from":[159],"cytoplasm.":[163],"conclusion,":[165],"our":[166,194],"suggest":[168],"dependent":[180],"on":[181],"status":[183],"differentiation,":[186],"i.e.,":[187],"maturation.":[188],"construct":[191],"used":[192],"studies":[195],"serve":[197],"drug":[201],"carrier":[202],"developing":[204],"botulism":[205],"countermeasures.":[206]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
