{"id":"https://openalex.org/W2400926869","doi":null,"title":"Pretreatment with a nontoxic derivative of endotoxin induces functional protection against cardiac ischemia/reperfusion injury.","display_name":"Pretreatment with a nontoxic derivative of endotoxin induces functional protection against cardiac ischemia/reperfusion injury.","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2400926869","mag":"2400926869","pmid":"https://pubmed.ncbi.nlm.nih.gov/1858044"},"language":"en","primary_location":{"id":"pmid:1858044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1858044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024776025","display_name":"Nelson Dw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D W Nelson","raw_affiliation_strings":["Department of Surgery, University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088764154","display_name":"Brown Jm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Banerjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Banerjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109555512","display_name":"D.D. Bensard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D D Bensard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042012054","display_name":"Rogers Kb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K B Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058164284","display_name":"Cristee R. Locke-Winter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C R Locke-Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063822600","display_name":"Benjamin O. Anderson","orcid":"https://orcid.org/0000-0001-7217-7428","observed_orcids":["https://orcid.org/0000-0001-7217-7428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B O Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087253902","display_name":"Alden H. Harken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Harken","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0936,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.79759278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"110","issue":"2","first_page":"365","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monophosphoryl-lipid-a","display_name":"monophosphoryl lipid A","score":0.9739999771118164},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9520000219345093},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ventricular-function","display_name":"ventricular function","score":0.9520000219345093},{"id":"https://openalex.org/keywords/global-myocardial-ischemia","display_name":"global myocardial ischemia","score":0.6470000147819519},{"id":"https://openalex.org/keywords/pretreatment-timing","display_name":"pretreatment timing","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8296728134155273},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6694104075431824},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6120114922523499},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5641369223594666},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5473232269287109},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.474735826253891},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3923832178115845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2987474799156189},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.18080085515975952},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.05401906371116638}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1858044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1858044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"mag:2400926869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1858044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2446727077","display_name":"CELLULAR OXIDATIVE TARGETS IN CARDIAC REPERFUSION INJURY","funder_award_id":"5r29hl043696-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386693944","display_name":"CYTOKINE ENHANCEMENT OF POST-ISCHEMIC CARDIAC FUNCTION","funder_award_id":"5r01hl044186-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165523226","https://openalex.org/W2108706233","https://openalex.org/W2082797302","https://openalex.org/W2082834850","https://openalex.org/W2367474042","https://openalex.org/W2388722955","https://openalex.org/W2030667474","https://openalex.org/W2058631782","https://openalex.org/W2019487543","https://openalex.org/W1979295898"],"abstract_inverted_index":{"We":[0,165],"hypothesized":[1],"that":[2,167],"low-dose":[3],"pretreatment":[4,37,169],"of":[5,13,29,51,62,71,96,107,110,124],"an":[6],"intact":[7],"animal":[8],"with":[9,116,137,159,170,200],"a":[10,60,67,80],"nontoxic":[11],"derivative":[12],"endotoxin,":[14],"monophosphoryl":[15],"lipid":[16],"A":[17],"(MPL),":[18],"would":[19,38],"induce":[20,39],"protection":[21,41,174,180],"against":[22,42,175],"cardiac":[23,43,176],"ischemia/reperfusion":[24],"(I/R)":[25],"injury.":[26],"The":[27],"purposes":[28],"this":[30],"study":[31],"were":[32,65],"to":[33,46,54,152],"investigate":[34],"whether":[35],"MPL":[36,72,117,138,160,171],"functional":[40,173,202],"I/R":[44,177],"injury,":[45,178],"delineate":[47],"the":[48,201],"temporal":[49],"induction":[50,58],"protection,":[52],"and":[53,76,156,194],"examine":[55],"antioxidant":[56],"enzyme":[57,192],"as":[59],"mechanism":[61],"protection.":[63,203],"Rats":[64],"administered":[66],"5":[68],"mg/kg":[69],"dose":[70],"at":[73,183,188],"2":[74,161,184],"hours":[75,78,119,140,162],"24":[77,118,139,189],"before":[79,120,141,163],"25-minute,":[81],"global,":[82],"37":[83],"degrees":[84],"C":[85],"ischemic":[86],"insult":[87],"followed":[88],"by":[89],"reperfusion":[90],"(modified":[91],"Langendorff).":[92],"At":[93],"40":[94],"minutes":[95],"reperfusion,":[97],"ventricular":[98,125],"function":[99,126],"was":[100],"assessed":[101],"(ventricular":[102],"balloon;":[103],"developed":[104],"pressure,":[105],"rate":[106,109],"contraction,":[108],"relaxation).":[111],"Hearts":[112],"from":[113,134],"rats":[114,135,157],"pretreated":[115,136,154,158],"isolation":[121,142],"exhibited":[122],"preservation":[123],"(p":[127,145],"less":[128,146],"than":[129,147],"0.05).":[130],"After":[131],"I/R,":[132],"hearts":[133],"had":[143],"increased":[144,196],"0.05)":[148],"catalase":[149,197],"activity":[150,198],"compared":[151],"saline":[153],"controls":[155],"isolation.":[164],"conclude":[166],"(1)":[168],"induces":[172],"(2)":[179],"(not":[181],"evident":[182],"hours)":[185],"is":[186],"maximal":[187],"hours,":[190],"suggesting":[191],"induction,":[193],"(3)":[195],"correlates":[199]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
