{"id":"https://openalex.org/W2400675378","doi":null,"title":"Arachidonic acid metabolites are involved in mediating red blood cell adherence to endothelium.","display_name":"Arachidonic acid metabolites are involved in mediating red blood cell adherence to endothelium.","publication_year":1995,"publication_date":"1995-05-01","ids":{"openalex":"https://openalex.org/W2400675378","mag":"2400675378","pmid":"https://pubmed.ncbi.nlm.nih.gov/7537788"},"language":"en","primary_location":{"id":"pmid:7537788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7537788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069713302","display_name":"Yamaja B.N. Setty","orcid":"https://orcid.org/0000-0002-7012-4063","observed_orcids":["https://orcid.org/0000-0002-7012-4063"]},"institutions":[{"id":"https://openalex.org/I4210160682","display_name":"St. Christopher's Hospital for Children","ror":"https://ror.org/05t3ett24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B N Setty","raw_affiliation_strings":["Division of Pediatric Hematology-Oncology, St. Christopher's Hospital for Children, Philadelphia, PA 19134-1095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology-Oncology, St. Christopher's Hospital for Children, Philadelphia, PA 19134-1095, USA","institution_ids":["https://openalex.org/I4210160682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049623621","display_name":"Carlton Dampier","orcid":"https://orcid.org/0000-0002-7738-2620","observed_orcids":["https://orcid.org/0000-0002-7738-2620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C D Dampier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074333907","display_name":"Stuart Mj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Stuart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3198,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.77370031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"125","issue":"5","first_page":"608","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.22920000553131104,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.08669999986886978,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.8009999990463257},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolites","display_name":"arachidonic acid metabolites","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lipoxygenase-pathway","display_name":"lipoxygenase pathway","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cyclooxygenase-pathway","display_name":"cyclooxygenase pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nordihydroguaiaretic-acid","display_name":"nordihydroguaiaretic acid","score":0.9279999732971191},{"id":"https://openalex.org/keywords/15-hydroxyeicosatetraenoic-acid","display_name":"15-hydroxyeicosatetraenoic acid","score":0.7889999747276306},{"id":"https://openalex.org/keywords/12-hydroxyeicosatetraenoic-acid","display_name":"12-hydroxyeicosatetraenoic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sickle-red-blood-cells","display_name":"sickle red blood cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.6600000262260437},{"id":"https://openalex.org/keywords/leukocyte-endothelial-interaction","display_name":"leukocyte-endothelium interaction","score":0.652999997138977},{"id":"https://openalex.org/keywords/platelet-leukocyte-interaction","display_name":"platelet-leukocyte interaction","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8368116617202759},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.7869811654090881},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.7727462649345398},{"id":"https://openalex.org/C2776889390","wikidata":"https://www.wikidata.org/wiki/Q7050774","display_name":"Nordihydroguaiaretic acid","level":4,"score":0.7479796409606934},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.681435763835907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5417606830596924},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4976220428943634},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.47224801778793335},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.4340960383415222},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4263575077056885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41061824560165405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3387477993965149},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3185081481933594},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29967230558395386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25638681650161743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17840459942817688}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015777","descriptor_name":"Eicosanoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016024","descriptor_name":"Receptors, Cytoadhesin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016024","descriptor_name":"Receptors, Cytoadhesin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7537788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7537788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2400675378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7537788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1903910955","display_name":"EICOSANOIDS IN THE COMPLICATION OF SICKLE CELL ANEMIA","funder_award_id":"R01HL045969","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2372526661","display_name":"SICKLE CELL ANEMIA--EICOSANOIDS IN HYPOXIC INJURY","funder_award_id":"R01HL051497","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991764613","https://openalex.org/W1566165238","https://openalex.org/W2177578670","https://openalex.org/W2411131493","https://openalex.org/W7098569312","https://openalex.org/W2110628158","https://openalex.org/W2047840115","https://openalex.org/W4392345859","https://openalex.org/W1995208678","https://openalex.org/W2090805356"],"abstract_inverted_index":{"As":[0,288],"an":[1,101,245],"initial":[2],"investigation":[3],"into":[4],"the":[5,17,28,63,86,90,118,135,138,142,153,198,236,248,260,280,298,328,352,367],"possible":[6],"role":[7,143,350,375],"of":[8,19,30,61,72,85,108,144,163,176,195,217,239,247,282,300,359],"endothelial":[9],"cell":[10],"(EC)":[11],"lipoxygenase":[12,64,139,201,353],"and":[13,42,54,58,65,81,128,137,188,197,295,315,322,333,364],"cyclooxygenase":[14,66,87,136,369],"metabolites":[15,354,370],"in":[16,112,169,267,284,355,376],"adherence":[18,48,91,119,238,299,329],"red":[20],"blood":[21],"cells":[22],"(RBCs)":[23],"to":[24,74,97,114,149,165,179,264,273,278,303,337,343,361,372],"ECs,":[25,78,292],"we":[26,233,269],"evaluated":[27],"effect":[29,95,102,226,326],"nordihydroguaiaretic":[31],"acid,":[32],"(NDGA;":[33],"10":[34],"mumols/L,":[35],"BW755c":[36],"(30":[37],"mumols/L),":[38,41],"aspirin":[39,80,293],"(100":[40,147],"indomethacin":[43],"(10":[44,335],"mumols/L)":[45],"on":[46,103,152,227,251,327],"RBC-EC":[47],"using":[49,211],"a":[50,170,192,213,349],"static":[51],"incubation":[52],"system":[53],"51Cr-labeled":[55],"RBCs.":[56],"NDGA":[57,296],"3-amino-L-[3'-(trifluoromethyl)phenyl]-2-pyrazoline":[59],"inhibitors":[60,84],"both":[62,331,362],"pathways,":[67],"significantly":[68],"decreased":[69,297],"basal":[70,161,357],"adhesion":[71,162,342,358],"RBCs":[73,164,241,302,360],"fetal":[75],"bovine":[76,122,166,252,290],"aortic":[77,123,167,253,291],"whereas":[79],"indomethacin,":[82],"selective":[83],"pathway,":[88],"stimulated":[89,204,294,340],"process.":[92,120,229,378],"The":[93],"inhibitor":[94],"appeared":[96],"be":[98],"mediated":[99,243],"via":[100,134,244],"EC":[104],"functions,":[105],"since":[106],"preincubation":[107],"ECs":[109,124,168,277,310],"with":[110,173,219,289],"NDGA,":[111],"contrast":[113],"RBC-NDGA":[115],"preincubation,":[116],"inhibited":[117],"Because":[121,255],"generate":[125],"mainly":[126],"prostacyclin":[127,209,218],"15-HETE":[129,159,196,332],"from":[130,317],"arachidonic":[131],"acid":[132],"(AA)":[133],"pathways":[140],"respectively,":[141],"these":[145],"products":[146],"pmol/L":[148,336],"1":[150,187],"mumol/L)":[151],"adhesive":[154],"process":[155],"was":[156,242],"further":[157,231],"assessed.":[158],"potentiated":[160],"concentration-dependent":[171],"manner,":[172],"maximal":[174],"responses":[175],"approximately":[177],"50%":[178],"150%":[180],"over":[181],"baseline":[182],"noted":[183],"at":[184],"concentrations":[185],"between":[186],"100":[189,338],"nmol/L":[190],"12-HETE,":[191],"structural":[193],"isomer":[194],"major":[199,368],"platelet":[200],"product,":[202],"also":[203],"RBC":[205,341],"adherence.":[206],"In":[207,230],"contrast,":[208],"(assessed":[210],"carbacyclin,":[212],"stable":[214],"synthetic":[215],"analog":[216],"similar":[220],"biologic":[221],"properties)":[222],"had":[223,324],"no":[224,325,374],"significant":[225],"this":[228,377],"studies,":[232],"demonstrated":[234],"that":[235],"12-HETE-induced":[237],"sickle":[240,285,301],"up-regulation":[246],"vitronectin":[249],"receptor":[250],"endothelium.":[254,307,345],"microvascular":[256,309,365],"capillary":[257,276,306,344],"endothelium":[258],"is":[259],"surface":[261],"most":[262],"likely":[263],"encounter":[265],"erythrocytes":[266],"vivo,":[268],"extended":[270],"our":[271],"studies":[272,347],"human":[274,304],"retinal":[275,305],"assess":[279],"involvement":[281],"eicosanoids":[283],"RBC-microvessel":[286],"adhesion.":[287],"These":[308],"generated":[311],"prostacyclin,":[312],"HHT,":[313],"15-HETE,":[314],"15-HPETE":[316,334],"endogenous":[318],"AA.":[319],"Although":[320],"carbacyclin":[321],"HHT":[323],"process,":[330],"nmol/L)":[339],"Our":[346],"document":[348],"for":[351],"modulating":[356],"macrovascular":[363],"endothelium;":[366],"appear":[371],"play":[373]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}