{"id":"https://openalex.org/W2400640362","doi":null,"title":"The Chediak-Higashi gene in humans. III. Studies on the mechanisms of NK impairment.","display_name":"The Chediak-Higashi gene in humans. III. Studies on the mechanisms of NK impairment.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2400640362","mag":"2400640362","pmid":"https://pubmed.ncbi.nlm.nih.gov/6839545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536889"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1536889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111715744","display_name":"John Roder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J C Roder","raw_affiliation_strings":["Queen\u2019s University Kingston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen\u2019s University Kingston","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034993321","display_name":"Robert F. Todd","orcid":"https://orcid.org/0000-0002-7591-5139","observed_orcids":["https://orcid.org/0000-0002-7591-5139"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R F Todd","raw_affiliation_strings":["Queen\u2019s University Kingston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen\u2019s University Kingston","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108529366","display_name":"Peter Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P Rubin","raw_affiliation_strings":["Queen\u2019s University Kingston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen\u2019s University Kingston","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074187114","display_name":"Tina P. Haliotis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Haliotis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008689556","display_name":"Stephen L. Helfand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Helfand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108548663","display_name":"J. A. Werkmeister","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Werkmeister","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111989733","display_name":"Hugh F. Pross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H F Pross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109593257","display_name":"Laurence A. Boxer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Boxer","raw_affiliation_strings":["Pediatrics - Hematology/Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics - Hematology/Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109066087","display_name":"Stuart F. Schlossman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S F Schlossman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108647800","display_name":"A S Fauci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Fauci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9235,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75327068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"51","issue":"2","first_page":"359","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.2865999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chediak-higashi-syndrome","display_name":"Chediak-Higashi syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/okm1","display_name":"OKM1","score":0.6930000185966492},{"id":"https://openalex.org/keywords/mac-1","display_name":"Mac-1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/large-granular-lymphocytes","display_name":"large granular lymphocytes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/oxygen-intermediates","display_name":"oxygen intermediates","score":0.5759999752044678},{"id":"https://openalex.org/keywords/chemiluminescence","display_name":"chemiluminescence","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-cell-lysis","display_name":"tumor cell lysis","score":0.800000011920929},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C48679268","wikidata":"https://www.wikidata.org/wiki/Q3375169","display_name":"Percoll","level":3,"score":0.8726511001586914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7026501893997192},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.6648854613304138},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5949376225471497},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5517647862434387},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5004115104675293},{"id":"https://openalex.org/C2776070026","wikidata":"https://www.wikidata.org/wiki/Q934034","display_name":"Ch\u00e9diak\u2013Higashi syndrome","level":2,"score":0.4885607659816742},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.45968860387802124},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.4582293629646301},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4308667778968811},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30261749029159546},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.20602655410766602},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16765499114990234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09738057851791382}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002499","descriptor_name":"Centrifugation, Density Gradient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002609","descriptor_name":"Chediak-Higashi Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1536889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:6839545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6839545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:2400640362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6839545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1536889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1536889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1484629663","https://openalex.org/W1504600626","https://openalex.org/W1528682116","https://openalex.org/W1531457203","https://openalex.org/W1567106414","https://openalex.org/W1924778996","https://openalex.org/W1975744984","https://openalex.org/W1980535421","https://openalex.org/W2007835830","https://openalex.org/W2027335406","https://openalex.org/W2027922729","https://openalex.org/W2058250164","https://openalex.org/W2058428642","https://openalex.org/W2087708213","https://openalex.org/W2094668768","https://openalex.org/W2100673560","https://openalex.org/W2117596832","https://openalex.org/W2133166743","https://openalex.org/W2146814362","https://openalex.org/W2161082695","https://openalex.org/W2404831155","https://openalex.org/W2410988306","https://openalex.org/W2417467491","https://openalex.org/W4313310658"],"related_works":["https://openalex.org/W97346630","https://openalex.org/W1572106051","https://openalex.org/W2004018208","https://openalex.org/W2007458001","https://openalex.org/W2146814362","https://openalex.org/W2094668768","https://openalex.org/W2029403209","https://openalex.org/W2133166743","https://openalex.org/W2027163839","https://openalex.org/W7095856087"],"abstract_inverted_index":{"Lymphocytes":[0],"from":[1],"six":[2],"Chediak-Higashi":[3],"(CH)":[4],"patients":[5,150,213],"were":[6,84],"markedly":[7],"depressed":[8],"in":[9,17,87,90,128,148,182,196,200,211,216,227],"their":[10],"ability":[11],"to":[12,159,163,232],"lyse":[13],"tumour":[14,164],"cell":[15,23],"targets":[16],"both":[18],"51Cr":[19],"release":[20],"and":[21,34,44,54,73,126,138,161],"single":[22],"cytotoxicity":[24],"assays.":[25],"The":[26,154],"frequency":[27,36,218],"of":[28,37,81,108,114,119,144,156,174,235],"lymphocytes":[29,158],"bearing":[30],"the":[31,35,66,74,91,111,120,142,145,171,179,201,228,233,240],"OKM1":[32,125],"marker":[33,113],"T3+,":[38],"T4+,":[39],"T8+,":[40],"Ia+,":[41],"Mo1+,":[42],"Mo2+":[43],"B1+":[45],"cells":[46,83,109,121,165,181,210],"was":[47,166,170],"normal":[48,88,168,217],"among":[49],"sheep":[50],"erythrocyte":[51],"rosetting":[52],"(E+)":[53],"non-rosetting":[55],"(E-)":[56],"peripheral":[57],"blood":[58],"leucocytes":[59],"analysed":[60],"by":[61,123,178],"flow":[62],"cytofluorography.":[63],"Cells":[64],"expressing":[65,110],"NK":[67,82,94,133,146,180,202,209],"shared":[68],"markers,":[69],"OKM1,":[70],"mac-1,":[71],"FcR,":[72],"characteristic":[75],"large":[76],"granular":[77],"lymphocyte":[78],"(LGL)":[79],"morphology":[80],"also":[85,167],"present":[86,215],"numbers":[89,107],"highly":[92],"enriched":[93],"fraction":[95,102,130],"separated":[96],"on":[97],"Percoll":[98],"density":[99],"gradients.":[100],"This":[101],"did":[103],"not":[104],"contain":[105],"detectable":[106],"Mo2":[112],"human":[115],"monocytes.":[116],"Therefore":[117],"most":[118],"stained":[122],"monoclonal":[124],"mac-1":[127],"this":[129],"are":[131,214,220],"likely":[132],"cells,":[134],"rather":[135],"than":[136],"monocytes,":[137],"we":[139],"conclude":[140],"that":[141,190,208],"size":[143],"pool":[147],"CH":[149,157,212],"is":[151,193],"probably":[152],"normal.":[153],"capacity":[155],"recognize":[160],"bind":[162],"as":[169],"subsequent":[172,198,231],"burst":[173,234],"oxygen":[175,236],"intermediates":[176,237],"produced":[177],"a":[183],"chemiluminenscence":[184],"assay.":[185],"We":[186],"have":[187],"shown":[188],"elsewhere":[189],"O2-":[191],"generation":[192],"directly":[194],"involved":[195],"activating":[197],"steps":[199],"cytolytic":[203,229],"pathway.":[204],"These":[205],"results":[206],"suggest":[207],"but":[219,238],"blocked":[221],"at":[222],"some":[223],"post-recognition,":[224],"post-activation":[225],"step":[226],"pathway":[230],"preceding":[239],"lethal":[241],"hit.":[242]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
