{"id":"https://openalex.org/W2400635669","doi":null,"title":"System identification of skin conductance response in depression - an attempt to probe the neurochemistry of limbic system.","display_name":"System identification of skin conductance response in depression - an attempt to probe the neurochemistry of limbic system.","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2400635669","mag":"2400635669","pmid":"https://pubmed.ncbi.nlm.nih.gov/18827756"},"language":"en","primary_location":{"id":"pmid:18827756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18827756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Danubina","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038983291","display_name":"Sa\u0161a Brankovi\u0107","orcid":"https://orcid.org/0000-0003-0475-5358","observed_orcids":["https://orcid.org/0000-0003-0475-5358"]},"institutions":[{"id":"https://openalex.org/I4210113171","display_name":"Univerzitetski Klini\u010dki Centar Srbije","ror":"https://ror.org/02122at02","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210113171"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Sasa B Brankovi\u0107","raw_affiliation_strings":["Institute of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia. sasabrank@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia. sasabrank@yahoo.com","institution_ids":["https://openalex.org/I4210113171"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038983291"],"corresponding_institution_ids":["https://openalex.org/I4210113171"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.39959677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"20","issue":"3","first_page":"310","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.4113999903202057,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.4113999903202057,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.188400000333786,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-conductance-response","display_name":"skin conductance response","score":0.9739999771118164},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/system-identification","display_name":"system identification","score":0.9649999737739563},{"id":"https://openalex.org/keywords/feedback-loops","display_name":"feedback loops","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.5170000195503235},{"id":"https://openalex.org/keywords/emotional-arousal","display_name":"emotional arousal","score":0.6380000114440918},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.7509999871253967},{"id":"https://openalex.org/keywords/neurotransmitter-imbalance","display_name":"neurotransmitter imbalance","score":0.8119999766349792},{"id":"https://openalex.org/keywords/antidepressant-response-prediction","display_name":"antidepressant response prediction","score":0.9330000281333923},{"id":"https://openalex.org/keywords/autonomic-regulation","display_name":"autonomic regulation","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.8530826568603516},{"id":"https://openalex.org/C111902132","wikidata":"https://www.wikidata.org/wiki/Q1326834","display_name":"Skin conductance","level":2,"score":0.7208183407783508},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6462437510490417},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6039580702781677},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.5795783996582031},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.576573371887207},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5500046014785767},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5482603907585144},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4701395630836487},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4562656879425049},{"id":"https://openalex.org/C541082541","wikidata":"https://www.wikidata.org/wiki/Q192560","display_name":"Limbic system","level":3,"score":0.43732336163520813},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.38254866003990173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3632762134075165},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3443217873573303},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.20482796430587769},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.13162878155708313},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12014573812484741},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004644","descriptor_name":"Emotions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004644","descriptor_name":"Emotions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005712","descriptor_name":"Galvanic Skin Response","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011932","descriptor_name":"Reading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014705","descriptor_name":"Verbal Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D033262","descriptor_name":"Narration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035061","descriptor_name":"Control Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18827756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18827756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Danubina","raw_type":"Comparative Study"},{"id":"mag:2400635669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18827756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W8440616","https://openalex.org/W115158135","https://openalex.org/W253326700","https://openalex.org/W610302870","https://openalex.org/W1508825618","https://openalex.org/W1817626063","https://openalex.org/W1936268729","https://openalex.org/W1972269081","https://openalex.org/W1977542480","https://openalex.org/W1981111416","https://openalex.org/W1992530238","https://openalex.org/W1993886635","https://openalex.org/W2010827508","https://openalex.org/W2018222414","https://openalex.org/W2026344745","https://openalex.org/W2026791180","https://openalex.org/W2028684628","https://openalex.org/W2037894906","https://openalex.org/W2040634382","https://openalex.org/W2043862042","https://openalex.org/W2044584315","https://openalex.org/W2044879021","https://openalex.org/W2057656400","https://openalex.org/W2063035659","https://openalex.org/W2066223279","https://openalex.org/W2085473431","https://openalex.org/W2087918728","https://openalex.org/W2095125093","https://openalex.org/W2114613490","https://openalex.org/W2121991951","https://openalex.org/W2132384525","https://openalex.org/W2133044012","https://openalex.org/W2146152534","https://openalex.org/W2147289447","https://openalex.org/W2148919430","https://openalex.org/W2154155279","https://openalex.org/W2325507166","https://openalex.org/W2469517484"],"related_works":["https://openalex.org/W4205283245","https://openalex.org/W3192079536","https://openalex.org/W2021145606","https://openalex.org/W4414806767","https://openalex.org/W1971366990","https://openalex.org/W2927166626","https://openalex.org/W2008329764","https://openalex.org/W2355317338","https://openalex.org/W3011614573","https://openalex.org/W2610033279"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Choice":[1],"of":[2,13,26,31,40,55,64,90,105,125,142,150,157,174],"antidepressant":[3],"is":[4,164],"a":[5,28,88,95,177],"daily":[6],"problem":[7],"in":[8,36,44,53,60,80,122,128,133,139,172],"clinical":[9],"work.":[10],"Clinical":[11],"predictors":[12],"therapeutic":[14],"response":[15,34,175],"to":[16,76,166,176],"antidepressants":[17],"are":[18],"not":[19],"yet":[20],"available.":[21],"We":[22,135],"explored":[23],"the":[24,38,41,45,56,62,70,123,140,143,147,154],"possibility":[25],"using":[27],"signal":[29],"analysis":[30],"skin":[32],"conductance":[33],"(SCR)":[35],"specifying":[37],"imbalances":[39],"neurotransmitter":[42],"systems":[43],"brain.":[46],"SUBJECTS":[47],"AND":[48],"METHODS:":[49],"The":[50,101,160],"method":[51],"consists":[52],"application":[54],"system":[57],"identification":[58],"theory":[59],"analyzing":[61],"regulation":[63],"SCR.":[65],"Eleven":[66],"short":[67],"stories":[68],"from":[69],"contemporary":[71],"literature":[72],"have":[73,113],"been":[74,114],"used":[75],"elicit":[77],"emotional":[78],"arousal":[79],"subjects.":[81],"Participants":[82],"were":[83],"divided":[84],"into":[85],"two":[86,108],"groups,":[87],"group":[89,98],"depressed":[91,117],"patients":[92,118],"(n=57),":[93],"and":[94,119,152],"healthy":[96,120],"control":[97],"(n=52).":[99],"RESULTS:":[100],"resulting":[102],"mathematical":[103],"model":[104],"SCR":[106],"revealed":[107],"feedback":[109,131],"loops.":[110],"Significant":[111],"differences":[112],"found":[115],"between":[116],"subjects":[121],"sense":[124],"stronger":[126],"signals":[127],"both":[129],"identified":[130],"loops":[132],"depression.":[134,158],"considered":[136],"these":[137],"results":[138],"context":[141],"data":[144],"regarding:":[145],"(i)":[146],"functional":[148],"neuroanatomy":[149],"SCR,":[151],"(ii)":[153],"neurochemical":[155],"characteristics":[156],"CONCLUSION:":[159],"methodological":[161],"approach":[162],"that":[163],"still":[165],"be":[167,170],"examined":[168],"could":[169],"useful":[171],"prediction":[173],"specific":[178],"antidepressant.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}