{"id":"https://openalex.org/W2400622162","doi":null,"title":"[Expression and significance of hypoxia-inducible factor-1\u03b1 in lung tissues of obesity-asthma rat].","display_name":"[Expression and significance of hypoxia-inducible factor-1\u03b1 in lung tissues of obesity-asthma rat].","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2400622162","mag":"2400622162","pmid":"https://pubmed.ncbi.nlm.nih.gov/25481182"},"language":"zh","primary_location":{"id":"pmid:25481182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25481182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100443789","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0003-0997-1869","observed_orcids":["https://orcid.org/0000-0003-0997-1869","https://orcid.org/0000-0002-5780-4582"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Chen","raw_affiliation_strings":["Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061997541","display_name":"Hou-shuang Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Houshuang Pei","raw_affiliation_strings":["Department of Respiratory Medicine, Central Hospital, Datun Coal and Electricity Group Co., Ltd, Xuzhou 221611, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Central Hospital, Datun Coal and Electricity Group Co., Ltd, Xuzhou 221611, China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102025864","display_name":"Shuyang Zhu","orcid":"https://orcid.org/0000-0002-9998-6476","observed_orcids":["https://orcid.org/0000-0002-9998-6476"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyang Zhu","raw_affiliation_strings":["Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057936233","display_name":"Jiechen Zhu","orcid":"https://orcid.org/0000-0001-9121-3156","observed_orcids":["https://orcid.org/0000-0001-9121-3156"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiechen Zhu","raw_affiliation_strings":["Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210106614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024593205","display_name":"Ruirui Shi","orcid":"https://orcid.org/0000-0002-8178-5254","observed_orcids":["https://orcid.org/0000-0002-8178-5254","https://orcid.org/0009-0003-9268-1658"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruirui Shi","raw_affiliation_strings":["Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221000, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210106614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2421,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61015307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"30","issue":"12","first_page":"1262","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.753000020980835},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/airway-wall-thickness","display_name":"airway wall thickness","score":0.8379999995231628},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.875},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6039999723434448},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lung-tissue","display_name":"lung tissue","score":0.5130000114440918},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5090000033378601},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3140000104904175},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.8106006383895874},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6445474624633789},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.6194056272506714},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5752783417701721},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5742140412330627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5705965757369995},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.5558155179023743},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.5463632941246033},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5127414464950562},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5121462345123291},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.509547233581543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5087841153144836},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.47018539905548096},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3725241422653198},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36180418729782104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3438073992729187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2860562801361084},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1961701512336731},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.15790784358978271},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25481182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25481182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"English Abstract"},{"id":"mag:2400622162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25481182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2390879088","https://openalex.org/W2350807469","https://openalex.org/W2339358974","https://openalex.org/W2143519655","https://openalex.org/W6939358310","https://openalex.org/W2377591173","https://openalex.org/W6958430250","https://openalex.org/W6940052161","https://openalex.org/W6939930147","https://openalex.org/W6939959583"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,11,105,123,137,166,178,344,353,378,387],"expression":[4,143,179,287,337,359],"level":[5],"of":[6,14,122,144,155,165,180,192,221,259,288,338,347,360,381],"hypoxia-inducible":[7],"factor-1\u03b1":[8],"(HIF-1\u03b1)":[9],"in":[10,60,72,81,90,112,146,157,170,195,197,208,225,236,248,263,274,290,295,310,350,362,384],"rat":[12,87],"model":[13],"diet-induced":[15,85],"obesity":[16],"and":[17,52,64,75,93,97,133,172,215,240,280,293,301,315,323,327,332,352,364,386],"asthma.":[18],"METHODS:":[19],"Forty":[20],"male":[21],"specific":[22],"pathogen-free":[23],"SD":[24],"rats":[25,40,55,59,370],"were":[26,66,77,95,182,298,305],"randomly":[27],"divided":[28],"into":[29],"four":[30],"groups:":[31],"normal":[32,42],"body":[33,43],"mass":[34,44],"control":[35,48],"group":[36,49,62,73,91,198,209,212,216,226,237,241,249,264,275,278,281,296,311,319,328],"(group":[37,45,50,56],"A),":[38],"asthmatic":[39,54,106,369],"with":[41,99,177,246,343,377],"B),":[46],"obese":[47,53,86,368],"C)":[51],"D).":[57],"The":[58,108,119,142,153,163,189,219,257,286,336,358],"both":[61],"A":[63,210,238,276,312],"B":[65,92,217,250,282,329],"fed":[67,78],"basic":[68],"diet,":[69],"while":[70],"those":[71,207,235,273,309],"C":[74,213,320],"D":[76,94,199,227,265,297],"high-fat":[79],"diet":[80],"order":[82],"to":[83,103],"establish":[84,104],"model.":[88,107],"Rats":[89],"sensitized":[96],"challenged":[98],"chicken":[100],"ovalbumin":[101],"(OVA)":[102],"white":[109,168,193,348,382],"cell":[110],"count":[111],"bronchoalveolar":[113],"lavage":[114],"fluid":[115],"(BALF)":[116],"was":[117,127,134,149,159,200,203,228,231,253,266,269,340],"performed.":[118],"total":[120,167,190,345,379],"area":[121],"airway":[124,173,222,354,388],"wall":[125,174,223,355,389],"(Wat)":[126],"measured":[128],"by":[129,136,151,161,184],"ImagePro":[130],"Plus":[131],"software":[132],"standardized":[135],"basement":[138],"membrane":[139],"perimeter":[140],"(Pbm).":[141],"HIF-1\u03b1":[145,156,181,260,289,339,361],"lung":[147,365],"tissue":[148,366],"detected":[150],"immunohistochemistry.":[152],"concentration":[154],"serum":[158,292,363],"determined":[160],"ELISA.":[162],"relationships":[164],"cells":[169,194,262,349,383],"BALF":[171,196,294,351,385],"thickness":[175,220],"(WAt/Pbm)":[176,224],"analyzed":[183],"Pearson":[185],"correlation":[186],"analysis.":[187],"RESULTS:":[188],"number":[191,346,380],"(98.0\u00b15.5)\u00d710(4)/mL,":[201],"which":[202,230,268,304,373],"significantly":[204,232,270,306,371],"higher":[205,233,271,307],"than":[206,234,272,308],"(24.7\u00b13.3)\u00d710(4)/mL,":[211],"(26.1\u00b13.8)\u00d710(4)/mL":[214],"(87.8\u00b17.1)\u00d710(4)/mL.":[218],"(9.91\u00b10.56)m(2)/m,":[229],"(6.11\u00b10.99)m(2)/m":[239],"C(5.99\u00b10.83)m(2)/m,":[242],"but":[243],"when":[244],"compared":[245],"that":[247],"(8.60\u00b10.53)m(2)/m,":[251],"there":[252],"no":[254],"significant":[255],"difference.":[256],"percentage":[258],"positive":[261],"(19.44\u00b10.96)%,":[267],"(2.19\u00b10.91)%,":[277],"C(2.56\u00b10.89)%":[279],"(18.25\u00b11.29)%":[283],"(all":[284],"P<0.05).":[285],"blood":[291],"respectively(29.107\u00b11.576)":[299],"ng/mL":[300,314,322,331],"(0.511\u00b10.011)":[302],"ng/mL,":[303,317,325,334],"[(19.380\u00b11.506)":[313],"(0.280\u00b10.008)":[316],"respectively],":[318],"[(20.782\u00b12.034)":[321],"(0.281\u00b10.010)":[324],"respectively]":[326],"[(23.961\u00b11.565)":[330],"(0.397\u00b10.011)":[333],"respectively].":[335],"positively":[341,375],"correlated":[342,376],"thickness.":[356,390],"CONCLUSION:":[357],"from":[367],"increases,":[372],"is":[374]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
