{"id":"https://openalex.org/W2400567396","doi":"https://doi.org/10.5694/j.1326-5377.1980.tb134886.x","title":"USE OF LABETALOL IN MODERATE TO SEVERE HYPERTENSION","display_name":"USE OF LABETALOL IN MODERATE TO SEVERE HYPERTENSION","publication_year":1980,"publication_date":"1980-04-01","ids":{"openalex":"https://openalex.org/W2400567396","doi":"https://doi.org/10.5694/j.1326-5377.1980.tb134886.x","mag":"2400567396","pmid":"https://pubmed.ncbi.nlm.nih.gov/7393061"},"language":"en","primary_location":{"id":"doi:10.5694/j.1326-5377.1980.tb134886.x","doi":"https://doi.org/10.5694/j.1326-5377.1980.tb134886.x","is_oa":false,"landing_page_url":"https://doi.org/10.5694/j.1326-5377.1980.tb134886.x","pdf_url":null,"source":{"id":"https://openalex.org/S13978405","display_name":"The Medical Journal of Australia","issn_l":"0025-729X","issn":["0025-729X","1326-5377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Journal of Australia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050723916","display_name":"Ileene M. Macdonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ileene Macdonald","raw_affiliation_strings":["Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108603248","display_name":"A. S. P. Hua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. S. P. Hua","raw_affiliation_strings":["Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063871339","display_name":"G. W. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G. W. Thomas","raw_affiliation_strings":["Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068644879","display_name":"Keng Thye Woo","orcid":"https://orcid.org/0000-0001-7051-1728","observed_orcids":["https://orcid.org/0000-0001-7051-1728"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"K. T. Woo","raw_affiliation_strings":["Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112276527","display_name":"Judith Ann Whitworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Judith A. Whitworth","raw_affiliation_strings":["Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001212706","display_name":"Priscilla Kincaid\u2010Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Priscilla Kincaid\u2010Smith","raw_affiliation_strings":["Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nephrology and MedicineRoyal Melbourne HospitalParkvilleVic.3050","institution_ids":["https://openalex.org/I1320473756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001212706"],"corresponding_institution_ids":["https://openalex.org/I1320473756"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":1.4833,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83549213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"7","first_page":"325","last_page":"327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/labetalol","display_name":"labetalol","score":1.0},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.9670000076293945},{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.753000020980835},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9539999961853027},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.8320000171661377},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2777962398","wikidata":"https://www.wikidata.org/wiki/Q958087","display_name":"Labetalol","level":3,"score":0.9921502470970154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48312708735466003},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40119192004203796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3222382664680481},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.18336325883865356}],"mesh":[{"descriptor_ui":"D001581","descriptor_name":"Benzothiadiazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007741","descriptor_name":"Labetalol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007741","descriptor_name":"Labetalol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049993","descriptor_name":"Sodium Chloride Symporter Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5694/j.1326-5377.1980.tb134886.x","doi":"https://doi.org/10.5694/j.1326-5377.1980.tb134886.x","is_oa":false,"landing_page_url":"https://doi.org/10.5694/j.1326-5377.1980.tb134886.x","pdf_url":null,"source":{"id":"https://openalex.org/S13978405","display_name":"The Medical Journal of Australia","issn_l":"0025-729X","issn":["0025-729X","1326-5377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Journal of Australia","raw_type":"journal-article"},{"id":"pmid:7393061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7393061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Medical journal of Australia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2011298511","https://openalex.org/W2078530782","https://openalex.org/W2410564751","https://openalex.org/W2414248726"],"related_works":["https://openalex.org/W2417077178","https://openalex.org/W4301078183","https://openalex.org/W2397644728","https://openalex.org/W2474260597","https://openalex.org/W2039948395","https://openalex.org/W2074231614","https://openalex.org/W2415010346","https://openalex.org/W2161598339","https://openalex.org/W1903656489","https://openalex.org/W174265841"],"abstract_inverted_index":{"An":[0],"open":[1],"study":[2],"was":[3],"undertaken":[4],"in":[5,26],"31":[6],"patients":[7,50,60,71],"with":[8,28,32],"moderate":[9],"to":[10,13],"severe":[11],"hypertension":[12],"compare":[14],"labetalol":[15,68],"(a":[16],"competitive":[17],"antagonist":[18],"of":[19,35,47,53,77],"both":[20],"alpha-adrenoreceptors":[21],"and":[22,25,40,65,80,98],"beta-adrenoreceptors)":[23],"alone":[24],"combination":[27,34],"a":[29,33],"thiazide":[30],"diuretic,":[31],"thiazide,":[36],"beta-adrenergic":[37],"blocking":[38],"agent":[39],"the":[41],"alpha-adrenoreceptor":[42],"blocker":[43],"prazosin.":[44],"After":[45],"introduction":[46],"labetalol,":[48],"six":[49],"withdrew":[51,75],"because":[52,76],"intolerable":[54],"side":[55,78,94],"effects.":[56],"All":[57],"25":[58],"remaining":[59],"were":[61,72],"controlled":[62],"on":[63],"diuretic":[64],"labetalol.":[66],"On":[67],"alone,":[69],"14":[70],"controlled,":[73],"two":[74],"effects":[79,95],"nine":[81],"had":[82],"inadequate":[83],"blood":[84],"pressure":[85],"control.":[86],"Labetalol":[87],"is":[88],"an":[89],"effective":[90],"antihypertensive":[91],"agent,":[92],"but":[93],"are":[96],"common":[97],"it":[99],"has":[100],"few":[101],"advantages":[102],"over":[103],"drugs":[104],"presently":[105],"available.":[106]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}