{"id":"https://openalex.org/W2400436406","doi":null,"title":"Pharmacological activation of serotonergic activity in Atlantic salmon (Salmo salar): A model of chronic stress","display_name":"Pharmacological activation of serotonergic activity in Atlantic salmon (Salmo salar): A model of chronic stress","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2400436406","mag":"2400436406"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/41467","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/41467","pdf_url":"http://hdl.handle.net/10852/41467","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/41467","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010126275","display_name":"Kia Wee Tan","orcid":"https://orcid.org/0000-0001-7527-9905","observed_orcids":["https://orcid.org/0000-0001-7527-9905"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kia Wee Tan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7527-9905","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010126275"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.3127000033855438,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.121799997985363,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atlantic-salmon","display_name":"Atlantic salmon","score":0.8790000081062317},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.8629999756813049},{"id":"https://openalex.org/keywords/chronic-social-stress","display_name":"chronic social stress","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pharmacological-activation","display_name":"pharmacological activation","score":0.5619999766349792},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.847000002861023},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/surfacing-behavior","display_name":"surfacing behavior","score":0.8450000286102295},{"id":"https://openalex.org/keywords/heart-size","display_name":"heart size","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2777940460","wikidata":"https://www.wikidata.org/wiki/Q310436","display_name":"Salmo","level":3,"score":0.9669721126556396},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.879715085029602},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.42747071385383606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3735013008117676},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.33374491333961487},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.32542967796325684},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.2677498459815979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08365869522094727},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/41467","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/41467","pdf_url":"http://hdl.handle.net/10852/41467","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2400436406","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/41467/14/Master-Thesis-Kia-Wee.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/41467","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/41467","pdf_url":"http://hdl.handle.net/10852/41467","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2400436406.pdf","grobid_xml":"https://content.openalex.org/works/W2400436406.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1583817176","https://openalex.org/W1943801147","https://openalex.org/W1964042817","https://openalex.org/W1967927766","https://openalex.org/W1971793821","https://openalex.org/W1972267410","https://openalex.org/W1973398439","https://openalex.org/W1974540641","https://openalex.org/W1974806308","https://openalex.org/W1979039453","https://openalex.org/W1979295154","https://openalex.org/W1985178630","https://openalex.org/W1985983832","https://openalex.org/W1991436104","https://openalex.org/W1998691660","https://openalex.org/W2001330446","https://openalex.org/W2003642652","https://openalex.org/W2004185567","https://openalex.org/W2004563925","https://openalex.org/W2005331389","https://openalex.org/W2006192644","https://openalex.org/W2006986749","https://openalex.org/W2013548020","https://openalex.org/W2015083532","https://openalex.org/W2016870566","https://openalex.org/W2018129006","https://openalex.org/W2019284117","https://openalex.org/W2019442286","https://openalex.org/W2021134386","https://openalex.org/W2025775221","https://openalex.org/W2027813455","https://openalex.org/W2029267980","https://openalex.org/W2029934505","https://openalex.org/W2031599166","https://openalex.org/W2032813086","https://openalex.org/W2035276215","https://openalex.org/W2036221679","https://openalex.org/W2039613541","https://openalex.org/W2040223373","https://openalex.org/W2043045418","https://openalex.org/W2050607994","https://openalex.org/W2051530922","https://openalex.org/W2054193501","https://openalex.org/W2055930553","https://openalex.org/W2058225085","https://openalex.org/W2058703779","https://openalex.org/W2061528078","https://openalex.org/W2061926947","https://openalex.org/W2064899241","https://openalex.org/W2065209840","https://openalex.org/W2068946044","https://openalex.org/W2069019979","https://openalex.org/W2070636161","https://openalex.org/W2073023377","https://openalex.org/W2074268823","https://openalex.org/W2074796005","https://openalex.org/W2075182826","https://openalex.org/W2075819625","https://openalex.org/W2076507733","https://openalex.org/W2079023947","https://openalex.org/W2080867987","https://openalex.org/W2084661609","https://openalex.org/W2087299407","https://openalex.org/W2088093088","https://openalex.org/W2088169443","https://openalex.org/W2092554522","https://openalex.org/W2099445531","https://openalex.org/W2100438223","https://openalex.org/W2101034745","https://openalex.org/W2101892854","https://openalex.org/W2102375624","https://openalex.org/W2102977671","https://openalex.org/W2114360276","https://openalex.org/W2116707460","https://openalex.org/W2117532073","https://openalex.org/W2118163991","https://openalex.org/W2119205557","https://openalex.org/W2125716823","https://openalex.org/W2129961199","https://openalex.org/W2131763634","https://openalex.org/W2132539548","https://openalex.org/W2133610130","https://openalex.org/W2134236543","https://openalex.org/W2136061619","https://openalex.org/W2144601324","https://openalex.org/W2145079751","https://openalex.org/W2148128722","https://openalex.org/W2148637867","https://openalex.org/W2161365979","https://openalex.org/W2165402895","https://openalex.org/W2169202485","https://openalex.org/W2170165650","https://openalex.org/W2333643186","https://openalex.org/W2466292012"],"related_works":["https://openalex.org/W2121255681","https://openalex.org/W7128539377","https://openalex.org/W4410309633","https://openalex.org/W2766821246","https://openalex.org/W2396211087","https://openalex.org/W2724648075","https://openalex.org/W2053414468","https://openalex.org/W2505727230","https://openalex.org/W2320898978","https://openalex.org/W2339719510"],"abstract_inverted_index":{"Chronic":[0],"stress":[1,13,48,76,214,272],"is":[2,60],"the":[3,22,71,74,79,122,137,225,234,268,271],"principal":[4],"component":[5],"to":[6,50,106,116,157,205,256,278],"many":[7,110,232],"human":[8],"and":[9,20,55,78,89,136,140,150,176,190,199,237,252,274],"animal":[10],"disorders.":[11],"As":[12],"responses":[14,142],"are":[15,70,202],"remarkably":[16],"conserved":[17],"between":[18],"mammals":[19],"teleosts,":[21],"use":[23,265],"of":[24,66,73,81,84,94,125,196,224,233,244,250,263,270],"teleosts":[25],"in":[26,34,62,100,109,113,160,211,228,241,266],"comparative":[27],"models":[28,93,243],"has":[29,103],"been":[30,104],"a":[31,63,161],"useful":[32],"tool":[33],"neurobiology.":[35],"In":[36,91,119],"particular,":[37],"salmonid":[38,92,242],"fishes":[39],"have":[40],"emerged":[41],"as":[42,87],"model":[43],"organisms":[44],"for":[45,133,154],"chronic":[46,95,212,245],"social":[47,53,96,213,246],"due":[49],"their":[51],"well-characterized":[52],"behavior":[54,149],"physiology.":[56],"The":[57,248],"serotonergic":[58,98,123,175,226,258],"system":[59,124,227],"involved":[61],"wide":[64],"variety":[65],"functions,":[67],"among":[68],"which":[69],"control":[72],"neuroendocrine":[75],"response":[77,273],"regulation":[80],"an":[82,151],"array":[83],"behaviors":[85],"such":[86],"feeding":[88],"aggression.":[90],"stress,":[97],"activity":[99],"subordinate":[101,209],"individuals":[102],"found":[105,240],"be":[107,262],"elevated":[108,180],"brain":[111,173],"regions,":[112],"some":[114],"instances":[115],"pathological":[117],"levels.":[118,194],"this":[120],"study,":[121],"Atlantic":[126,229],"salmon":[127,170,230],"was":[128],"pharmacologically":[129],"activated":[130],"with":[131],"fluoxetine":[132,168,251],"18":[134],"days":[135],"behavioral,":[138],"physiological":[139,200,238],"neurochemical":[141],"were":[143],"examined.":[144],"Fluoxetine":[145],"induced":[146],"anorexia,":[147],"surfacing":[148],"increased":[152,172],"tendency":[153],"treated":[155,169],"fish":[156],"position":[158],"themselves":[159],"head":[162],"up,":[163],"tail":[164],"down":[165],"position.":[166],"Physiologically,":[167],"had":[171],"stem":[174],"norepinephrine":[177],"activity,":[178],"greatly":[179],"cortisol":[181],"levels,":[182],"larger":[183],"relative":[184],"heart":[185],"sizes,":[186],"upregulated":[187],"hypothalamic":[188],"AVT":[189],"5-HT1A\u03b2":[191],"receptor":[192],"mRNA":[193],"All":[195],"these":[197],"behavioral":[198,236],"parameters":[201],"strikingly":[203],"similar":[204],"those":[206],"exhibited":[207],"by":[208],"salmonids":[210],"models.":[215],"These":[216],"results":[217],"indicate":[218],"that":[219,276],"long":[220],"term":[221],"pharmacological":[222,254],"activation":[223],"recapitulates":[231],"typical":[235],"markers":[239],"stress.":[247],"utilization":[249],"other":[253],"tools":[255],"manipulate":[257],"signaling":[259],"may":[260],"thus":[261],"further":[264],"elucidating":[267],"intricacies":[269],"mechanisms":[275],"lead":[277],"its":[279],"dysfunction.":[280]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2016-06-24T00:00:00"}
