{"id":"https://openalex.org/W2400105440","doi":null,"title":"[Expression of phosphatase and tensin homolog in lower rectal cancer on neoadjuvant chemoradiotherapy].","display_name":"[Expression of phosphatase and tensin homolog in lower rectal cancer on neoadjuvant chemoradiotherapy].","publication_year":2010,"publication_date":"2010-10-19","ids":{"openalex":"https://openalex.org/W2400105440","mag":"2400105440","pmid":"https://pubmed.ncbi.nlm.nih.gov/21162897"},"language":"zh","primary_location":{"id":"pmid:21162897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21162897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019062173","display_name":"Jianhua Jin","orcid":"https://orcid.org/0000-0001-8051-6338","observed_orcids":["https://orcid.org/0000-0001-8051-6338"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-hua Jin","raw_affiliation_strings":["Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China. jjh20102010@163.com","Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China. jjh20102010@163.com","institution_ids":["https://openalex.org/I115592961"]},{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003913684","display_name":"Ya-xiong Rong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-xiong Rong","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016017312","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-5280-2967","observed_orcids":["https://orcid.org/0000-0002-5280-2967"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003889190","display_name":"Xiyuan Xu","orcid":"https://orcid.org/0000-0003-0440-323X","observed_orcids":["https://orcid.org/0000-0003-0440-323X"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi-yuan Xu","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen-bin Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-bin Lu","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076941367","display_name":"Xianwen Li","orcid":"https://orcid.org/0000-0003-1935-2391","observed_orcids":["https://orcid.org/0000-0003-1935-2391","https://orcid.org/0000-0002-4567-2172"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian-wen Li","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521082","display_name":"Jianzhong Deng","orcid":"https://orcid.org/0000-0001-5377-0779","observed_orcids":["https://orcid.org/0000-0001-5377-0779"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-zhong Deng","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hua Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":["Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,Affiliated Wujin People's Hospital, Jiangsu University, Changzhou 213002, China","institution_ids":["https://openalex.org/I115592961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020463878","display_name":"Xue-zhong Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xue-zhong Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113831894","display_name":"Zhixin Xue","orcid":"https://orcid.org/0000-0003-2125-570X","observed_orcids":["https://orcid.org/0000-0003-2125-570X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-xin Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33475229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"90","issue":"38","first_page":"2684","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9100000262260437},{"id":"https://openalex.org/keywords/low-rectal-cancer","display_name":"low rectal cancer","score":0.765999972820282},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-downstaging","display_name":"tumor downstaging","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sphincter-preservation","display_name":"sphincter preservation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pten-expression","display_name":"PTEN expression","score":0.7070000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5569999814033508},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.8059155941009521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7998918294906616},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7690844535827637},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.7615476846694946},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.757147490978241},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.7015292048454285},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6941400766372681},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5814511775970459},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5157608985900879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.445770800113678},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3777780532836914},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.1315174102783203},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0953458845615387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06881889700889587},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.050276219844818115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:21162897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21162897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2366582975","https://openalex.org/W2016331718","https://openalex.org/W2394088028","https://openalex.org/W2466828168","https://openalex.org/W2356195278","https://openalex.org/W2274652375","https://openalex.org/W2229423995","https://openalex.org/W2374383964","https://openalex.org/W3029860677","https://openalex.org/W2982173707"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2],"the":[3,58,61,64,72,99,200],"expression":[4,73,157],"of":[5,74,82,118,132,147,202],"phosphatase":[6],"and":[7,46,68,70,155,205],"tensin":[8],"homolog":[9],"deleted":[10],"on":[11,19,33,161],"chromosome":[12],"ten":[13],"(PTEN)":[14],"in":[15,39,113,158,179,188],"low":[16,30],"rectal":[17,31,181],"cancer":[18,32,159,182,203],"neoadjuvant":[20,66,77,85,162,170,177,213],"chemoradiotherapy":[21,67,86,163,171,178,214],"with":[22,29,35,108],"capecitabine":[23,36],"plus":[24],"radiotherapy.":[25],"METHODS:":[26],"Sixty-six":[27],"patients":[28,83,127,183],"therapy":[34],"(1650":[37],"mg\u00d7m(-2)\u00d7d(-1)":[38],"2":[40,51],"divided":[41],"doses)":[42],"for":[43],"two":[44],"course":[45],"concurrent":[47],"radiotherapy":[48],"(50":[49],"Gy,":[50],"Gy/day,":[52],"5":[53],"days":[54],"a":[55,207],"week).":[56],"Then":[57],"investigators":[59],"analyzed":[60],"relationship":[62],"between":[63],"preoperative":[65,176,212],"prognosis":[69],"measured":[71],"PTEN":[75,153,197],"during":[76],"chemoradiotherapy.":[78],"RESULTS:":[79],"92.4%":[80],"(61/66)":[81],"received":[84],"as":[87],"planned.":[88],"87.9%":[89,139],"(58/66)":[90],"tumor":[91,95],"stages":[92],"were":[93,164],"down-staged,":[94],"size":[96],"decreased":[97],"while":[98],"distance":[100],"from":[101],"anal":[102],"edge":[103],"increased.":[104],"And":[105],"curative":[106],"resection":[107],"sphincter-sparing":[109],"was":[110,121,138,144],"carried":[111],"out":[112],"all":[114],"patients.":[115],"The":[116,134,141,152,175],"rate":[117,137],"sphincter":[119,194],"preservation":[120],"90.9%":[122],"(60/66).":[123],"Among":[124],"which,":[125],"85.5%":[126],"showed":[128],"an":[129,145,216],"excellent":[130],"function":[131],"sphincter.":[133],"2-year":[135],"survival":[136,142,209],"(58/66).":[140],"period":[143],"average":[146],"35.3":[148],"months":[149],"(range:":[150],"25-60).":[151],"mRNA":[154],"protein":[156],"tissues":[160],"significantly":[165],"higher":[166],"than":[167],"those":[168],"before":[169],"(P=0.0079,":[172],"0.0269).":[173],"CONCLUSIONS:":[174],"lower":[180],"has":[184],"shown":[185],"its":[186],"efficacy":[187],"down-staging":[189],"cancer,":[190],"enhancing":[191],"resectability,":[192],"offering":[193],"preservation,":[195],"up-regulating":[196],"expression,":[198],"promoting":[199],"apoptosis":[201],"cell":[204],"achieving":[206],"better":[208],"rate.":[210],"Thus":[211],"is":[215],"effective":[217],"adjuvant":[218],"measure.":[219]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}