{"id":"https://openalex.org/W23999710","doi":null,"title":"tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.","display_name":"tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W23999710","mag":"23999710","pmid":"https://pubmed.ncbi.nlm.nih.gov/2216457"},"language":"en","primary_location":{"id":"pmid:2216457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2216457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025785724","display_name":"I Firmbach-Kraft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Firmbach-Kraft","raw_affiliation_strings":["Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109148729","display_name":"Mary G. Byers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Byers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113582122","display_name":"Thomas B. Shows","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Shows","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012955086","display_name":"Riccardo Dalla\u2010Favera","orcid":"https://orcid.org/0000-0002-3502-8826","observed_orcids":["https://orcid.org/0000-0002-3502-8826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Dalla-Favera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066862339","display_name":"John J. Krolewski","orcid":"https://orcid.org/0000-0002-7662-7489","observed_orcids":["https://orcid.org/0000-0002-7662-7489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Krolewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9018,"has_fulltext":false,"cited_by_count":320,"citation_normalized_percentile":{"value":0.912533,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"5","issue":"9","first_page":"1329","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.45190000534057617,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.45190000534057617,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.29829999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.21799999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyk2","display_name":"TYK2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.8519999980926514},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lymphoid-cells","display_name":"lymphoid cells","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8453487753868103},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.7349292039871216},{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.6204285025596619},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5604713559150696},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.5454668402671814},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.5215149521827698},{"id":"https://openalex.org/C130523297","wikidata":"https://www.wikidata.org/wiki/Q14914487","display_name":"Tyrosine kinase 2","level":5,"score":0.4711170196533203},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4583546221256256},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4341166317462921},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.4273381531238556},{"id":"https://openalex.org/C2911166042","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor Protein-Tyrosine Kinases","level":4,"score":0.42100173234939575},{"id":"https://openalex.org/C177917778","wikidata":"https://www.wikidata.org/wiki/Q14905188","display_name":"GRB2","level":4,"score":0.41157734394073486},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.411128431558609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36577898263931274},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3449927568435669},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.32470470666885376},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.22502806782722473},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18460321426391602},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1776050329208374},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002888","descriptor_name":"Chromosomes, Human, Pair 19","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2216457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2216457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:23999710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2216457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2543003056","display_name":"MAPPING MOLECULAR DISEASE AND CANCER-RELATED GENES","funder_award_id":"R01GM020454","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2652337885","display_name":"GENETICS OF HUMAN DEVELOPMENT AND METABOLIC DISEASE","funder_award_id":"R01HD005196","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6785039256","display_name":"MOLECULAR PATHOLOGY OF HUMAN LYMPOID MALIGNANCIES","funder_award_id":"R01CA044029","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W55668390","https://openalex.org/W155816776","https://openalex.org/W160967443","https://openalex.org/W2469374120","https://openalex.org/W2038350276","https://openalex.org/W2568059451","https://openalex.org/W2032737334","https://openalex.org/W2411327851","https://openalex.org/W2096503154","https://openalex.org/W1780824832"],"abstract_inverted_index":{"We":[0,31,122],"previously":[1,117],"identified":[2,118],"a":[3,12,18,37,72,76,90,131],"novel":[4],"protein":[5,74,104,120,136],"tyrosine":[6,19,105,137],"kinase":[7,20],"gene,":[8],"tyk2,":[9],"by":[10],"screening":[11],"human":[13],"lymphoid":[14],"cDNA":[15,41,63],"library":[16],"with":[17,75],"domain":[21],"specific":[22],"c-fms":[23],"restriction":[24],"fragment":[25],"under":[26],"low":[27],"stringency":[28],"hybridization":[29],"conditions.":[30],"have":[32],"now":[33],"isolated":[34],"and":[35,52,56,69],"sequenced":[36],"full":[38],"length":[39],"tyk2":[40,126],"clone;":[42],"demonstrated":[43],"that":[44,125],"this":[45],"gene":[46],"is":[47,65,94,127],"widely":[48],"expressed":[49],"in":[50,96,115],"hematopoietic":[51],"non-hematopoietic":[53],"cell":[54],"lines;":[55],"mapped":[57],"it":[58],"to":[59],"chromosome":[60],"19p13.2.":[61],"The":[62],"clone":[64],"4176":[66],"nucleotides":[67],"long":[68],"codes":[70],"for":[71],"putative":[73],"molecular":[77],"weight":[78],"of":[79,84,99,103,130,134],"134":[80],"kilodaltons.":[81],"Hydrophobicity":[82],"analysis":[83],"our":[85],"sequence":[86],"does":[87],"not":[88],"identify":[89],"transmembrane":[91],"domain,":[92,113],"which":[93],"found":[95,114],"all":[97,116],"members":[98],"the":[100,128],"receptor":[101],"class":[102,133],"kinases;":[106],"nor":[107],"can":[108],"we":[109],"detect":[110],"an":[111],"SH2":[112],"non-receptor":[119,135],"kinases.":[121,138],"therefore":[123],"propose":[124],"prototype":[129],"new":[132]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}