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Received November 9, 2015; aUnidad de Gesti\u00f3n Cl\u00ednica de Enfermedades Digestivas, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de M\u00e1laga, CIBERehd, M\u00e1laga; bServicio de Digestivo, Hospital Mendaro; cServicio de Digestivo, Hospital Mondrag\u00f3n, Guip\u00fazcoa; dDepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular III/Inmunolog\u00eda, Instituto de Investigaci\u00f3n Biosanitario de Granada, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada; e-mail: [email\u00a0protected]; eServicio de Gastroenterolog\u00eda, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, CIBERehd; fax: +34 952 131 568; gServicio de Aparato Digestivo, Hospital Morales Meseguer, Murcia; hServicio de Digestivo, Complejo Hospitalario Universitario de Albacete, Albacete; iUnidad de Hepatolog\u00eda, Servicio de Aparato Digestivo, Hospital Universitari i Polit\u00e8cnic La Fe, CIBERehd, Valencia, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I173304897","https://openalex.org/I2801795740","https://openalex.org/I4210116170","https://openalex.org/I4210132431","https://openalex.org/I4210157481","https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082237234","display_name":"Miguel \u00c1ngel L\u00f3pez\u2010Nevot","orcid":"https://orcid.org/0000-0002-3465-6062","observed_orcids":["https://orcid.org/0000-0002-3465-6062"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210157481","display_name":"Hospital Cl\u00ednico Universitario Virgen de la Victoria","ror":"https://ror.org/05xxs2z38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210157481"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel-\u00c1ngel L\u00f3pez-Nevot","raw_affiliation_strings":["Accepted April 25, 2016; 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Received November 9, 2015; aUnidad de Gesti\u00f3n Cl\u00ednica de Enfermedades Digestivas, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de M\u00e1laga, CIBERehd, M\u00e1laga; bServicio de Digestivo, Hospital Mendaro; cServicio de Digestivo, Hospital Mondrag\u00f3n, Guip\u00fazcoa; dDepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular III/Inmunolog\u00eda, Instituto de Investigaci\u00f3n Biosanitario de Granada, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada; e-mail: [email\u00a0protected]; eServicio de Gastroenterolog\u00eda, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, CIBERehd; fax: +34 952 131 568; gServicio de Aparato Digestivo, Hospital Morales Meseguer, Murcia; hServicio de Digestivo, Complejo Hospitalario Universitario de Albacete, Albacete; iUnidad de Hepatolog\u00eda, Servicio de Aparato Digestivo, Hospital Universitari i Polit\u00e8cnic La Fe, CIBERehd, Valencia, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I173304897","https://openalex.org/I2801795740","https://openalex.org/I4210116170","https://openalex.org/I4210132431","https://openalex.org/I4210157481","https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107830425","display_name":"Eva M. 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Received November 9, 2015; aUnidad de Gesti\u00f3n Cl\u00ednica de Enfermedades Digestivas, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de M\u00e1laga, CIBERehd, M\u00e1laga; bServicio de Digestivo, Hospital Mendaro; cServicio de Digestivo, Hospital Mondrag\u00f3n, Guip\u00fazcoa; dDepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular III/Inmunolog\u00eda, Instituto de Investigaci\u00f3n Biosanitario de Granada, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada; e-mail: [email\u00a0protected]; eServicio de Gastroenterolog\u00eda, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, CIBERehd; fax: +34 952 131 568; gServicio de Aparato Digestivo, Hospital Morales Meseguer, Murcia; hServicio de Digestivo, Complejo Hospitalario Universitario de Albacete, Albacete; iUnidad de Hepatolog\u00eda, Servicio de Aparato Digestivo, Hospital Universitari i Polit\u00e8cnic La Fe, CIBERehd, Valencia, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I173304897","https://openalex.org/I2801795740","https://openalex.org/I4210116170","https://openalex.org/I4210132431","https://openalex.org/I4210157481","https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054402510","display_name":"Aida Ortega\u2010Alonso","orcid":"https://orcid.org/0000-0002-8999-4093","observed_orcids":["https://orcid.org/0000-0002-8999-4093"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210157481","display_name":"Hospital Cl\u00ednico Universitario Virgen de la Victoria","ror":"https://ror.org/05xxs2z38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210157481"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aida Ortega-Alonso","raw_affiliation_strings":["Accepted April 25, 2016; 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Received November 9, 2015; aUnidad de Gesti\u00f3n Cl\u00ednica de Enfermedades Digestivas, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de M\u00e1laga, CIBERehd, M\u00e1laga; bServicio de Digestivo, Hospital Mendaro; cServicio de Digestivo, Hospital Mondrag\u00f3n, Guip\u00fazcoa; dDepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular III/Inmunolog\u00eda, Instituto de Investigaci\u00f3n Biosanitario de Granada, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada; e-mail: [email\u00a0protected]; eServicio de Gastroenterolog\u00eda, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, CIBERehd; fax: +34 952 131 568; gServicio de Aparato Digestivo, Hospital Morales Meseguer, Murcia; hServicio de Digestivo, Complejo Hospitalario Universitario de Albacete, Albacete; iUnidad de Hepatolog\u00eda, Servicio de Aparato Digestivo, Hospital Universitari i Polit\u00e8cnic La Fe, CIBERehd, Valencia, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I173304897","https://openalex.org/I2801795740","https://openalex.org/I4210116170","https://openalex.org/I4210132431","https://openalex.org/I4210157481","https://openalex.org/I4210164724","https://openalex.org/I82767444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032296928","display_name":"Francisco Ruiz\u2010Cabello","orcid":"https://orcid.org/0000-0002-2247-3293","observed_orcids":["https://orcid.org/0000-0002-2247-3293"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4210116170","display_name":"Hospital Universitario Virgen de las Nieves","ror":"https://ror.org/02f01mz90","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210116170"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210157481","display_name":"Hospital Cl\u00ednico Universitario Virgen de la Victoria","ror":"https://ror.org/05xxs2z38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210157481"]},{"id":"https://openalex.org/I4210164724","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga","ror":"https://ror.org/05n3asa33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210164724"]},{"id":"https://openalex.org/I82767444","display_name":"Universidad de M\u00e1laga","ror":"https://ror.org/036b2ww28","country_code":"ES","type":"education","lineage":["https://openalex.org/I82767444"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Ruiz-Cabello","raw_affiliation_strings":["Accepted April 25, 2016; 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Received November 9, 2015; aUnidad de Gesti\u00f3n Cl\u00ednica de Enfermedades Digestivas, Servicio de Farmacolog\u00eda Cl\u00ednica, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de M\u00e1laga, CIBERehd, M\u00e1laga; bServicio de Digestivo, Hospital Mendaro; cServicio de Digestivo, Hospital Mondrag\u00f3n, Guip\u00fazcoa; dDepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular III/Inmunolog\u00eda, Instituto de Investigaci\u00f3n Biosanitario de Granada, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Granada; e-mail: [email\u00a0protected]; eServicio de Gastroenterolog\u00eda, Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona, CIBERehd; fax: +34 952 131 568; gServicio de Aparato Digestivo, Hospital Morales Meseguer, Murcia; hServicio de Digestivo, Complejo Hospitalario Universitario de Albacete, Albacete; iUnidad de Hepatolog\u00eda, Servicio de Aparato Digestivo, Hospital Universitari i Polit\u00e8cnic La Fe, CIBERehd, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accepted April 25, 2016; 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