{"id":"https://openalex.org/W2399367456","doi":null,"title":"The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents.","display_name":"The role of macrophages in experimental arthritis induced by Streptococcus agalactiae sonicate: actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2399367456","mag":"2399367456","pmid":"https://pubmed.ncbi.nlm.nih.gov/1873358"},"language":"en","primary_location":{"id":"pmid:1873358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1873358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lymphokine and cytokine research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013529220","display_name":"A.-H.A. Abd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A H Abd","raw_affiliation_strings":["Department of Microbiology, University of Queensland, St. Lucia, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Queensland, St. Lucia, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112637061","display_name":"Neil W Savage","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N W Savage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111603369","display_name":"W.J. Halliday","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Halliday","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5121544496","display_name":"David Arthur Hume","orcid":"https://orcid.org/0000-0002-2615-1478","observed_orcids":["https://orcid.org/0000-0002-2615-1478"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D A Hume","raw_affiliation_strings":["Royal (Dick) School of Veterinary Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal (Dick) School of Veterinary Studies","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9737,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86397551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"10","issue":"1-2","first_page":"43","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9419999718666077},{"id":"https://openalex.org/keywords/rheumatoid-arthritis-model","display_name":"rheumatoid arthritis model","score":0.7749999761581421},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/csf-1","display_name":"CSF-1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ia-antigen-expression","display_name":"Ia antigen expression","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9800000190734863},{"id":"https://openalex.org/keywords/silica","display_name":"silica","score":0.9179999828338623},{"id":"https://openalex.org/keywords/carrageenan","display_name":"carrageenan","score":1.0},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7636452913284302},{"id":"https://openalex.org/C2777860557","wikidata":"https://www.wikidata.org/wiki/Q132949","display_name":"Streptococcus agalactiae","level":4,"score":0.6790768504142761},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5869427919387817},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5733070373535156},{"id":"https://openalex.org/C50442881","wikidata":"https://www.wikidata.org/wiki/Q426626","display_name":"Macrophage colony-stimulating factor","level":4,"score":0.5691016316413879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5147085785865784},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5121986269950867},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5108799338340759},{"id":"https://openalex.org/C2776001837","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneum","level":2,"score":0.4232966899871826},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36013275384902954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3115960359573364},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17252865433692932},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.16481804847717285},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06420820951461792},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001170","descriptor_name":"Arthritis, Infectious","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013010","descriptor_name":"Sonication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013292","descriptor_name":"Streptococcus agalactiae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1873358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1873358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lymphokine and cytokine research","raw_type":"Comparative Study"},{"id":"mag:2399367456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1873358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2065054671","https://openalex.org/W2098280147","https://openalex.org/W2029184071","https://openalex.org/W2150957292","https://openalex.org/W2323113905","https://openalex.org/W2122475221","https://openalex.org/W1972258963","https://openalex.org/W2013993334","https://openalex.org/W2553064437","https://openalex.org/W1966971616"],"abstract_inverted_index":{"Intraperitoneal":[0],"injection":[1,98,143],"of":[2,30,41,83,102,137,144,162,166,195,204],"Streptococcus":[3],"agalactiae":[4,34,79,97],"sonicated":[5],"cells":[6],"into":[7],"Wistar":[8],"rats":[9],"causes":[10],"a":[11,23,38,53,113],"chronic":[12,177],"relapsing":[13],"polyarthritis":[14],"resembling":[15],"human":[16,146],"rheumatoid":[17],"arthritis.":[18,196],"We":[19],"report":[20],"evidence":[21],"favoring":[22],"role":[24,82],"for":[25,192,201],"macrophages":[26,48,61,69,84],"in":[27,62,70,85,155,181],"the":[28,72,86,121,128,156,163,172,176],"pathology":[29,122,191],"this":[31,193],"disease.":[32],"S.":[33,78,96],"injected":[35],"ip":[36],"induced":[37,67],"high":[39,131],"level":[40],"tumor":[42],"necrosis":[43],"factor":[44,149],"release":[45],"by":[46,91,142],"peritoneal":[47,60],"isolated":[49],"subsequently,":[50],"and":[51,74,107,174],"had":[52],"similar":[54],"effect":[55,115],"when":[56],"added":[57],"to":[58,95,111,159],"control":[59],"culture.":[63],"Ia":[64],"antigen":[65],"was":[66,89,140],"on":[68,116],"both":[71],"peritoneum":[73],"affected":[75],"joints":[76],"following":[77],"injection.":[80],"The":[81,133,197],"disease":[87,129,157,173],"process":[88],"studied":[90],"treating":[92],"animals":[93],"prior":[94],"with":[99,152,183,188],"varying":[100],"concentrations":[101],"bacterial":[103],"lipopolysaccharide":[104],"(LPS),":[105],"silica,":[106],"carrageenan,":[108],"agents":[109],"known":[110],"have":[112,199],"biphasic":[114],"macrophage":[117,138,147],"function.":[118],"They":[119],"aggravated":[120],"at":[123,130],"low":[124],"doses":[125],"but":[126],"prevented":[127],"doses.":[132],"most":[134],"specific":[135],"alteration":[136],"levels":[139],"achieved":[141],"recombinant":[145],"colony-stimulating":[148],"(CSF-1).":[150],"Treatment":[151],"CSF-1":[153,167],"early":[154],"lead":[158],"significant":[160],"worsening":[161],"pathology.":[164],"Administration":[165],"after":[168],"2":[169],"weeks":[170],"reactivated":[171],"extended":[175],"phase.":[178],"These":[179],"data":[180],"combination":[182],"previous":[184],"findings":[185],"are":[186],"consistent":[187],"nonimmune,":[189],"macrophage-mediated":[190],"model":[194],"results":[198],"implications":[200],"therapeutic":[202],"application":[203],"CSF-1.":[205]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}