{"id":"https://openalex.org/W2399345349","doi":"https://doi.org/10.1097/pec.0000000000000601","title":"Colloids for the Initial Management of Severe Sepsis and Septic Shock in Pediatric Patients","display_name":"Colloids for the Initial Management of Severe Sepsis and Septic Shock in Pediatric Patients","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2399345349","doi":"https://doi.org/10.1097/pec.0000000000000601","mag":"2399345349","pmid":"https://pubmed.ncbi.nlm.nih.gov/26535507"},"language":"en","primary_location":{"id":"doi:10.1097/pec.0000000000000601","doi":"https://doi.org/10.1097/pec.0000000000000601","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pec.0000000000000601","pdf_url":null,"source":{"id":"https://openalex.org/S4210190147","display_name":"Pediatric Emergency Care","issn_l":"0749-5161","issn":["0749-5161","1535-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Emergency Care","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056153111","display_name":"Daniela Nasu Monteiro Medeiros","orcid":"https://orcid.org/0000-0002-6575-9806","observed_orcids":["https://orcid.org/0000-0002-6575-9806"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"funder","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daniela Nasu Monteiro Medeiros","raw_affiliation_strings":["From the *Pediatric Intensive Care Unit, Hospital Municipal Dr Mois\u00e9s Deutsch-M Boi Mirim; \u2020Pediatric Intensive Care Unit, Hospital Israelita Albert Einstein; and \u2021Pediatric Intensive Care Department, Instituto da Crian\u00e7a, S\u00e3o Paulo, Brazil","Pediatric Intensive Care Unit, Hospital Israelita Albert Einstein","Pediatric Intensive Care Unit, Hospital Municipal Dr Mois\u00e9s Deutsch\u2013M Boi Mirim"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Pediatric Intensive Care Unit, Hospital Municipal Dr Mois\u00e9s Deutsch-M Boi Mirim; \u2020Pediatric Intensive Care Unit, Hospital Israelita Albert Einstein; and \u2021Pediatric Intensive Care Department, Instituto da Crian\u00e7a, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Pediatric Intensive Care Unit, Hospital Israelita Albert Einstein","institution_ids":["https://openalex.org/I2800288331"]},{"raw_affiliation_string":"Pediatric Intensive Care Unit, Hospital Municipal Dr Mois\u00e9s Deutsch\u2013M Boi Mirim","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030907622","display_name":"Juliana Ferreira Ferranti","orcid":"https://orcid.org/0000-0002-8726-4839","observed_orcids":["https://orcid.org/0000-0002-8726-4839"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Juliana Ferreira Ferranti","raw_affiliation_strings":["Pediatric Intensive Care Unit, Hospital Municipal Dr Mois\u00e9s Deutsch\u2013M Boi Mirim"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Unit, Hospital Municipal Dr Mois\u00e9s Deutsch\u2013M Boi Mirim","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007255155","display_name":"Artur Figueiredo Delgado","orcid":"https://orcid.org/0000-0003-4362-9880","observed_orcids":["https://orcid.org/0000-0003-4362-9880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Artur Figueiredo Delgado","raw_affiliation_strings":["Pediatric Intensive Care Department, Instituto da Crian\u00e7a, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Department, Instituto da Crian\u00e7a, S\u00e3o Paulo, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045710184","display_name":"Werther Brunow de Carvalho","orcid":"https://orcid.org/0000-0002-9164-616X","observed_orcids":["https://orcid.org/0000-0002-9164-616X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Werther Brunow de Carvalho","raw_affiliation_strings":["Pediatric Intensive Care Department, Instituto da Crian\u00e7a, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Department, Instituto da Crian\u00e7a, S\u00e3o Paulo, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030907622","https://openalex.org/A5056153111"],"corresponding_institution_ids":["https://openalex.org/I2800288331"],"apc_list":null,"apc_paid":null,"fwci":0.3869,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.4106293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"11","first_page":"e11","last_page":"e16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colloids","display_name":"colloids","score":0.9210000038146973},{"id":"https://openalex.org/keywords/crystalloids","display_name":"crystalloids","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":1.0},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fluid-therapy","display_name":"fluid therapy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/starch","display_name":"starch","score":0.375},{"id":"https://openalex.org/keywords/gelatin","display_name":"gelatin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.6850000023841858},{"id":"https://openalex.org/keywords/dengue-shock-syndrome","display_name":"dengue shock syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.3970000147819519},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.38999998569488525},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.36000001430511475},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.460999995470047},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9164937138557434},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7123265266418457},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6768541932106018},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6208234429359436},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5204054117202759},{"id":"https://openalex.org/C2779412105","wikidata":"https://www.wikidata.org/wiki/Q415775","display_name":"Hydroxyethyl starch","level":2,"score":0.4831371009349823},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.47880348563194275},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3837123513221741},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2404698133468628},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1316177248954773},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003102","descriptor_name":"Colloids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/pec.0000000000000601","doi":"https://doi.org/10.1097/pec.0000000000000601","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pec.0000000000000601","pdf_url":null,"source":{"id":"https://openalex.org/S4210190147","display_name":"Pediatric Emergency Care","issn_l":"0749-5161","issn":["0749-5161","1535-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Emergency Care","raw_type":"journal-article"},{"id":"pmid:26535507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26535507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric emergency care","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1992489045","https://openalex.org/W1993432467","https://openalex.org/W2012594970","https://openalex.org/W2021101234","https://openalex.org/W2027157505","https://openalex.org/W2029980972","https://openalex.org/W2048245345","https://openalex.org/W2050003410","https://openalex.org/W2054707747","https://openalex.org/W2056677038","https://openalex.org/W2068734467","https://openalex.org/W2077133466","https://openalex.org/W2078330556","https://openalex.org/W2082299454","https://openalex.org/W2096883458","https://openalex.org/W2098923148","https://openalex.org/W2106068443","https://openalex.org/W2108359471","https://openalex.org/W2116065793","https://openalex.org/W2132269368","https://openalex.org/W2147976206","https://openalex.org/W2148706741","https://openalex.org/W2154696953","https://openalex.org/W2164091121","https://openalex.org/W2168412520","https://openalex.org/W2324525172","https://openalex.org/W2394649828","https://openalex.org/W2396043126","https://openalex.org/W4211094368"],"related_works":["https://openalex.org/W2390354516","https://openalex.org/W2062426071","https://openalex.org/W7096309114","https://openalex.org/W2605009869","https://openalex.org/W2149887564","https://openalex.org/W7016221188","https://openalex.org/W2765967969","https://openalex.org/W3030407136","https://openalex.org/W1491719965","https://openalex.org/W2560356270"],"abstract_inverted_index":{"AIM:":[0],"The":[1,34,115,134,255,314],"goal":[2],"of":[3,12,18,24,46,59,89,165,206,211,222,234,245,258,304,326,357,373],"this":[4],"study":[5,200],"was":[6,41,53,129,201,260,343],"to":[7,55,75,80,85,147,270,321,330,339],"perform":[8],"a":[9,159],"systematic":[10],"review":[11,194],"the":[13,16,21,44,49,57,60,70,95,144,148,172,232,242,302,324,335,346,352,368,376],"literature":[14],"assessing":[15],"use":[17,233,325],"colloids":[19,237,239,327],"for":[20,43,216],"initial":[22,243,341],"treatment":[23,244],"severe":[25,246],"sepsis":[26,108,247],"and":[27,48,91,109,113,118,229,236,253,262,278,299,362],"septic":[28,110,249,307],"shock":[29,250,293,308],"in":[30,241,251,265,345,371],"pediatric":[31],"patients.":[32],"DESIGN:":[33],"PICO":[35],"[Patient,":[36],"Intervention,":[37],"Comparison,":[38],"Outcome]":[39],"method":[40],"used":[42,54,94,122],"selection":[45,128],"studies,":[47,334],"Cochrane":[50,83,149],"Bias":[51,150],"Tool":[52],"analyze":[56],"quality":[58],"selected":[61,135,169,215],"studies.":[62],"DATA":[63],"SEARCH:":[64],"Relevant":[65],"studies":[66,282,315],"were":[67,121,137,153,168,178,193,214,220],"sought":[68],"using":[69],"following":[71,96],"databases:":[72],"EMBASE":[73],"(1980":[74,84],"March":[76,81,86],"2014),":[77,82,87],"PubMed":[78],"(1970":[79],"Web":[88],"Science,":[90],"Scopus.":[92],"Searches":[93],"key":[97,173],"words:":[98],"isotonic":[99],"solution,":[100,103],"crystalloid,":[101],"saline":[102],"colloid,":[104],"resuscitation,":[105],"fluid":[106,336],"therapy,":[107],"shock,":[111],"starch,":[112],"gelatin.":[114],"filters":[116],"children":[117,252],"clinical":[119,223],"trial":[120],"when":[123,375],"possible.":[124],"REVIEW":[125],"METHOD:":[126],"Study":[127],"performed":[130],"by":[131,139,155,158,310],"1":[132,295,300],"examiner.":[133,161],"articles":[136,145,167,213],"analyzed":[138,231,316],"2":[140,268],"examiners":[141],"who":[142],"validated":[143],"according":[146],"Tool.":[151],"Discrepancies":[152],"resolved":[154],"consensus":[156],"or":[157,189,192,197,238,248],"third":[160],"RESULT:":[162],"A":[163,209],"total":[164,210,256],"110":[166],"based":[170],"on":[171],"words.":[174],"Of":[175],"these,":[176],"99":[177],"excluded":[179],"because":[180,218,356],"they":[181,219,230,263],"assessed":[182,283,289],"postoperative":[183],"follow-up,":[184],"burn":[185],"cases,":[186],"cardiac":[187],"surgery,":[188],"nutritional":[190],"therapy":[191],"articles,":[195],"guidelines,":[196],"editorials.":[198],"One":[199],"included":[202],"after":[203],"an":[204],"analysis":[205,217],"previous":[207],"reviews.":[208],"12":[212],"reports":[221],"trials":[224],"conducted":[225],"with":[226,273,286,291,306],"prospective":[227],"cohorts":[228],"crystalloids":[235],"only":[240],"adolescents.":[254],"number":[257],"patients":[259,275,284,290,305],"4375,":[261],"ranged":[264],"age":[266],"from":[267],"months":[269],"15":[271,279],"years,":[272],"most":[274],"between":[276],"5":[277,288],"years.":[280],"Five":[281],"diagnosed":[285],"malaria,":[287],"dengue":[292],"syndrome,":[294],"studied":[296],"febrile":[297],"diseases,":[298],"examined":[301],"progression":[303],"caused":[309],"various":[311],"causes.":[312],"CONCLUSIONS:":[313],"did":[317],"not":[318],"find":[319],"evidence":[320],"suggest":[322],"that":[323],"is":[328,380],"superior":[329],"crystalloids.":[331],"In":[332],"some":[333],"volume":[337],"needed":[338],"achieve":[340],"stabilization":[342],"smaller":[344],"group":[347],"given":[348],"colloids.":[349],"Crystalloids":[350],"are":[351],"preferred":[353],"therapeutic":[354],"option":[355],"their":[358],"effectiveness,":[359],"low":[360],"cost,":[361],"wide":[363],"availability.":[364],"Colloids":[365],"may":[366],"be":[367],"first":[369],"choice":[370],"cases":[372],"malaria":[374],"central":[377],"nervous":[378],"system":[379],"affected.":[381]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}