{"id":"https://openalex.org/W2399255106","doi":"https://doi.org/10.1038/srep14959","title":"Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo","display_name":"Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo","publication_year":2015,"publication_date":"2015-10-09","ids":{"openalex":"https://openalex.org/W2399255106","doi":"https://doi.org/10.1038/srep14959","mag":"2399255106","pmid":"https://pubmed.ncbi.nlm.nih.gov/26449763","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4598825"},"language":"en","primary_location":{"id":"doi:10.1038/srep14959","doi":"https://doi.org/10.1038/srep14959","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep14959","pdf_url":"https://www.nature.com/articles/srep14959.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep14959.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100623946","display_name":"Ping Yang","orcid":"https://orcid.org/0000-0002-1641-9389","observed_orcids":["https://orcid.org/0000-0002-1641-9389"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Yang","raw_affiliation_strings":["Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018828419","display_name":"Yunfei Zhao","orcid":"https://orcid.org/0009-0006-3466-7059","observed_orcids":["https://orcid.org/0009-0006-3466-7059"]},"institutions":[{"id":"https://openalex.org/I4210116144","display_name":"Chongqing University of Education","ror":"https://ror.org/02d06s578","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210116144"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunfei Zhao","raw_affiliation_strings":["School of Biological &Chemical Engineering, Chongqing University of Education, Chongqing, 400067, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological &Chemical Engineering, Chongqing University of Education, Chongqing, 400067, China","institution_ids":["https://openalex.org/I4210116144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087112798","display_name":"Lei Zhao","orcid":"https://orcid.org/0000-0002-8365-7774","observed_orcids":["https://orcid.org/0000-0002-8365-7774"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhao","raw_affiliation_strings":["Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002252581","display_name":"Jun Yuan","orcid":"https://orcid.org/0000-0002-3908-6521","observed_orcids":["https://orcid.org/0000-0002-3908-6521"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Yuan","raw_affiliation_strings":["Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394237","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0001-7231-9860","observed_orcids":["https://orcid.org/0000-0001-7231-9860","https://orcid.org/0009-0005-0736-2412"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084184096","display_name":"Zac Varghese","orcid":"https://orcid.org/0000-0003-4477-9119","observed_orcids":["https://orcid.org/0000-0003-4477-9119"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zac Varghese","raw_affiliation_strings":["John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109140947","display_name":"J F Moorhead","orcid":"https://orcid.org/0000-0001-5933-0504","observed_orcids":["https://orcid.org/0000-0001-5933-0504"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John F. Moorhead","raw_affiliation_strings":["John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101753080","display_name":"Yaxi Chen","orcid":"https://orcid.org/0000-0002-6242-7152","observed_orcids":["https://orcid.org/0000-0002-6242-7152"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yaxi Chen","raw_affiliation_strings":["Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067526370","display_name":"Xiong Zhong Ruan","orcid":"https://orcid.org/0000-0001-5199-4971","observed_orcids":["https://orcid.org/0000-0001-5199-4971"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Xiong Z. Ruan","raw_affiliation_strings":["Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"]},{"raw_affiliation_string":"John Moorhead Research Laboratory, Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101753080"],"corresponding_institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.8677,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85846906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"14959","last_page":"14959"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.09749999642372131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/inflammatory-stress","display_name":"inflammatory stress","score":0.9409999847412109},{"id":"https://openalex.org/keywords/irs-1-serine-phosphorylation","display_name":"IRS-1 serine phosphorylation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pancreatic-beta-cell-apoptosis","display_name":"pancreatic beta-cell apoptosis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hepatic-gluconeogenesis","display_name":"hepatic gluconeogenesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7649999856948853},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.9020000100135803},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7232816219329834},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6666262745857239},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.6573487520217896},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5881646275520325},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5585224032402039},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5423790216445923},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4797400236129761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47720441222190857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4570602774620056},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4140098989009857},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3915429413318634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3873349726200104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3210963010787964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2532723844051361},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22572031617164612},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019893","descriptor_name":"Ribosomal Protein S6 Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep14959","doi":"https://doi.org/10.1038/srep14959","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep14959","pdf_url":"https://www.nature.com/articles/srep14959.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4598825","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4598825","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:26449763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26449763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1508257","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1508257/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports , 5 , Article 14959. (2015)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/srep14959","doi":"https://doi.org/10.1038/srep14959","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep14959","pdf_url":"https://www.nature.com/articles/srep14959.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1973137523","display_name":null,"funder_award_id":"2012CB517700","funder_id":"https://openalex.org/F4320327563","funder_display_name":"Major State Basic Research Development Program of China"},{"id":"https://openalex.org/G2374715605","display_name":null,"funder_award_id":"2012CB517500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3401931320","display_name":null,"funder_award_id":"81,390,354","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3633468917","display_name":"\u708e\u75c7\u72b6\u6001\u4e0bmTOR/ S6K\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\uff1a\u4e00\u4e2a\u65b0\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u5206\u5b50\u673a\u5236","funder_award_id":"30971389","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4759278986","display_name":null,"funder_award_id":"81270493","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5019685449","display_name":null,"funder_award_id":"973Program","funder_id":"https://openalex.org/F4320327563","funder_display_name":"Major State Basic Research Development Program of China"},{"id":"https://openalex.org/G5309151156","display_name":null,"funder_award_id":"2012CB517700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5695519120","display_name":null,"funder_award_id":"2012CB517700","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6462100946","display_name":null,"funder_award_id":"81400786","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7541678620","display_name":null,"funder_award_id":"2012CB517500","funder_id":"https://openalex.org/F4320327563","funder_display_name":"Major State Basic Research Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327563","display_name":"Major State Basic Research Development Program of China","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2399255106.pdf","grobid_xml":"https://content.openalex.org/works/W2399255106.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1518126931","https://openalex.org/W1534360145","https://openalex.org/W1596556260","https://openalex.org/W1782420827","https://openalex.org/W1968341708","https://openalex.org/W1984792991","https://openalex.org/W1996861095","https://openalex.org/W2001649002","https://openalex.org/W2009971361","https://openalex.org/W2018135697","https://openalex.org/W2023455728","https://openalex.org/W2034183783","https://openalex.org/W2048488935","https://openalex.org/W2048597447","https://openalex.org/W2052750950","https://openalex.org/W2059652342","https://openalex.org/W2061962106","https://openalex.org/W2071220268","https://openalex.org/W2073720428","https://openalex.org/W2078281362","https://openalex.org/W2085039511","https://openalex.org/W2090644981","https://openalex.org/W2096164842","https://openalex.org/W2102683312","https://openalex.org/W2105089901","https://openalex.org/W2114408909","https://openalex.org/W2118688616","https://openalex.org/W2126393987","https://openalex.org/W2129316761","https://openalex.org/W2131863766","https://openalex.org/W2136942127","https://openalex.org/W2143112776","https://openalex.org/W2145333208","https://openalex.org/W2147247395","https://openalex.org/W2152377123","https://openalex.org/W2153442288","https://openalex.org/W2156080804","https://openalex.org/W2158608859","https://openalex.org/W2165202791","https://openalex.org/W2171290692","https://openalex.org/W2334309509","https://openalex.org/W2411649973"],"related_works":["https://openalex.org/W1993446047","https://openalex.org/W2136829490","https://openalex.org/W7096506780","https://openalex.org/W2087144289","https://openalex.org/W2056059329","https://openalex.org/W1968341708","https://openalex.org/W1973948260","https://openalex.org/W1989472173","https://openalex.org/W2085845513","https://openalex.org/W7030250944"],"abstract_inverted_index":{"Insulin":[0],"resistance":[1,32,167],"is":[2],"closely":[3],"related":[4],"to":[5,62,113],"inflammatory":[6,29,64,70,105,131,177],"stress":[7,71,178],"and":[8,35,44,53,56,84,97,115,143,151,172,179],"the":[9,77,90,125,169,184],"mammalian":[10],"target":[11],"of":[12,26,79,163,187],"rapamycin/S6":[13],"kinase":[14],"(mTOR/S6K)":[15],"pathway.":[16],"The":[17],"present":[18],"study":[19],"investigated":[20],"whether":[21],"rapamycin,":[22],"a":[23,160],"specific":[24],"inhibitor":[25],"mTOR,":[27],"ameliorates":[28],"stress-induced":[30],"insulin":[31,73,111,127,166],"in":[33,36,48,59,95,98,149,154,170,173],"vitro":[34,96,171],"vivo.":[37,99],"We":[38],"used":[39],"tumor":[40],"necrosis":[41],"factor-alpha":[42],"(TNF-\u03b1)":[43],"interleukin-6":[45],"(IL-6)":[46],"stimulation":[47],"HepG2":[49],"hepatocytes,":[50],"C2C12":[51],"myoblasts":[52],"3T3-L1":[54],"adipocytes":[55],"casein":[57],"injection":[58],"C57BL/6J":[60],"mice":[61],"induce":[63],"stress.":[65],"Our":[66,157],"results":[67,158],"showed":[68],"that":[69],"impairs":[72],"signaling":[74,92,112,128],"by":[75,130],"reducing":[76],"expression":[78],"total":[80],"IRS-1,":[81],"p-IRS-1":[82],"(tyr632),":[83],"p-AKT":[85],"(ser473);":[86],"it":[87,134],"also":[88,123],"activates":[89],"mTOR/S6K":[91],"pathway":[93],"both":[94],"In":[100,119],"vitro,":[101],"rapamycin":[102,121,164],"treatment":[103,122],"reversed":[104],"cytokine-stimulated":[106],"IRS-1":[107],"serine":[108],"phosphorylation,":[109],"increased":[110],"AKT":[114],"enhanced":[116,144],"glucose":[117,152],"utilization.":[118],"vivo,":[120],"ameliorated":[124],"impaired":[126],"induced":[129,135],"stress,":[132],"but":[133],"pancreatic":[136,140],"\u03b2-cell":[137,141],"apoptosis,":[138],"reduced":[139],"function":[142],"hepatic":[145],"gluconeogenesis,":[146],"thereby":[147],"resulting":[148],"hyperglycemia":[150],"intolerance":[153],"casein-injected":[155],"mice.":[156],"indicate":[159],"paradoxical":[161],"effect":[162],"on":[165],"between":[168],"vivo":[174],"environments":[175],"under":[176],"provide":[180],"additional":[181],"insight":[182],"into":[183],"clinical":[185],"application":[186],"rapamycin.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
