{"id":"https://openalex.org/W2398960576","doi":null,"title":"[Antibiotic release by tricalcic phosphate bone implantation. In vitro and in vivo pharmacokinetics of different galenic forms].","display_name":"[Antibiotic release by tricalcic phosphate bone implantation. In vitro and in vivo pharmacokinetics of different galenic forms].","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2398960576","mag":"2398960576","pmid":"https://pubmed.ncbi.nlm.nih.gov/9138328"},"language":"fr","primary_location":{"id":"pmid:9138328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9138328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirurgie; memoires de l'Academie de chirurgie","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111916234","display_name":"Herv\u00e9 Thomazeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H Thomazeau","raw_affiliation_strings":["Laboratoire de recherche en Chirurgie (biom\u00e9canique et biomat\u00e9riaux), Facult\u00e9 de M\u00e9decine de Rennes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de recherche en Chirurgie (biom\u00e9canique et biomat\u00e9riaux), Facult\u00e9 de M\u00e9decine de Rennes","institution_ids":["https://openalex.org/I56067802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042347002","display_name":"Frantz L. Langlais","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Langlais","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2639,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.8815286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"121","issue":"9-10","first_page":"663","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.17520000040531158,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-tcp","display_name":"beta-tricalcium phosphate","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antibiotic-release","display_name":"antibiotic release","score":0.6660000085830688},{"id":"https://openalex.org/keywords/bone-implants","display_name":"bone implants","score":0.7020000219345093},{"id":"https://openalex.org/keywords/macroporosity","display_name":"macroporosity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6840000152587891},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.5059999823570251},{"id":"https://openalex.org/keywords/implant-shape","display_name":"implant shape","score":0.43299999833106995},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.6000000238418579},{"id":"https://openalex.org/keywords/staphylococcal-infections","display_name":"staphylococcal infections","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.6878931522369385},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6654247641563416},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6169806718826294},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.5980680584907532},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5921081304550171},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.523573100566864},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.504198431968689},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.47152265906333923},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4479510188102722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4435686469078064},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.4215778708457947},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3495735228061676},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30145785212516785},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23436182737350464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22962024807929993},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20270615816116333},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.19187140464782715},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.14826864004135132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11886727809906006},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10150027275085449},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.085547536611557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07536792755126953},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002130","descriptor_name":"Calcium Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9138328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9138328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chirurgie; memoires de l'Academie de chirurgie","raw_type":"Comparative Study"},{"id":"mag:2398960576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9138328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415201195","https://openalex.org/W2026052785","https://openalex.org/W2403774965","https://openalex.org/W1971359976","https://openalex.org/W2053023011","https://openalex.org/W2986625771","https://openalex.org/W1980304115","https://openalex.org/W134663619","https://openalex.org/W2112038899","https://openalex.org/W6891610585"],"abstract_inverted_index":{"The":[0,78,173,199],"purpose":[1],"of":[2,13,20,53,62,65,71,74,138,150,152,160,171,181,186,196,202,210,224,237,252,269],"this":[3,225],"study":[4,176],"was":[5,56,60,118,141],"to":[6,217],"evaluate":[7],"the":[8,11,42,51,54,63,66,72,75,109,114,116,121,125,139,144,153,161,164,169,178,193,208,211,220,230,245,253,258,261,267,270,273],"load":[9,52,140],"and":[10,34,38,50,69,166,239,263],"release":[12,79,105,117],"antibiotics":[14,182,271],"obtained":[15,183,204],"with":[16,205],"an":[17,103],"implant":[18],"made":[19],"a":[21,48,89,101,157,249],"macroporous":[22],"beta":[23],"tricalcium":[24],"phosphate":[25],"ceramic":[26,43,154],"(beta-TCP).":[27],"Two":[28],"parameters":[29],"have":[30],"been":[31,81],"assessed:":[32],"macroporosity":[33,149],"external":[35],"shape":[36],"(beads":[37],"parallelepipeds).":[39],"In":[40],"vitro,":[41],"beads":[44,68,93,127,165,232],"were":[45,214],"soaked":[46],"in":[47,85,163,174,192,244],"Vancomycin-aqueous-solution,":[49],"antibiotic":[55,162,226],"then":[57],"evaluated:":[58],"it":[59],"9.3%":[61],"weight":[64,73],"40%-porosity":[67,126],"4.6%":[70],"20%-porosity":[76],"beads.":[77],"has":[80],"evaluated":[82],"by":[83],"elution":[84],"phosphate-buffered-saline":[86],"(PBS).":[87],"With":[88],"20%":[90],"porosity,":[91],"12":[92],"(6.3":[94],"mm,":[95,129],"279":[96],"+/-":[97,131],"38":[98],"mg)":[99],"demonstrated":[100],"short":[102],"massive":[104],"which":[106,256,264],"ended":[107],"within":[108],"32":[110],"first":[111,145],"hours.":[112,147],"On":[113,229],"opposite,":[115,231],"sustained":[119],"until":[120,207],"third":[122,137,212],"week":[123,213],"for":[124,227],"(6.9":[128],"353":[130],"25":[132],"mg),":[133],"while":[134],"only":[135,234],"one":[136],"released":[142],"during":[143],"24":[146],"A":[148],"40%":[151],"could":[155,265],"allow":[156],"deep":[158],"incorporation":[159],"thus":[167],"decrease":[168],"rate":[170],"release.":[172],"vivo":[175],"compared":[177],"bone":[179,200],"concentrations":[180,201,236],"after":[184],"implantations":[185],"either":[187],"parallelepipedical":[188],"or":[189],"spherical":[190],"devices":[191],"distal":[194],"femurs":[195],"14":[197],"sheep.":[198],"Gentamicin":[203,243],"parallelepipeds":[206],"end":[209],"from":[215],"5":[216],"10":[218],"times":[219],"minimum":[221],"inhibitory":[222],"concentration":[223],"staphylococci.":[228],"achieved":[233],"low":[235],"Vancomycin":[238],"nearly":[240],"no":[241],"detectable":[242],"bone.":[246,274],"We":[247],"hypothesize":[248],"negative":[250],"effect":[251],"fibrous":[254],"tissue":[255],"fills":[257],"gaps":[259],"between":[260],"beads,":[262],"impair":[266],"diffusion":[268],"into":[272]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
