{"id":"https://openalex.org/W2398920779","doi":null,"title":"Lymphocyte function in experimental endemic syphilis of Syrian hamsters.","display_name":"Lymphocyte function in experimental endemic syphilis of Syrian hamsters.","publication_year":1985,"publication_date":"1985-09-01","ids":{"openalex":"https://openalex.org/W2398920779","mag":"2398920779","pmid":"https://pubmed.ncbi.nlm.nih.gov/2931353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453664"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035940340","display_name":"Omar Bagasra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Bagasra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031062473","display_name":"Harvey Kushner","orcid":"https://orcid.org/0000-0002-8451-1187","observed_orcids":["https://orcid.org/0000-0002-8451-1187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kushner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"S Hashemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hashemi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1705,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80879256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"1","first_page":"9","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11934","display_name":"Syphilis Diagnosis and Treatment","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endemic-syphilis","display_name":"endemic syphilis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/treponema-pallidum","display_name":"Treponema pallidum","score":0.9649999737739563},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lymphocyte-subsets","display_name":"lymphocyte subsets","score":0.7200000286102295},{"id":"https://openalex.org/keywords/thymic-atrophy","display_name":"thymic atrophy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/b-cell-function","display_name":"B cell function","score":0.7699999809265137},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5370000004768372},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6949999928474426},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.375},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.8810985684394836},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.7575851678848267},{"id":"https://openalex.org/C2780187896","wikidata":"https://www.wikidata.org/wiki/Q134745","display_name":"Treponema","level":4,"score":0.6834543347358704},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.6286959648132324},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6129825115203857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.590865433216095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5556243062019348},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.466505229473114},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.43799135088920593},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4299573302268982},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2315838634967804},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.22941410541534424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21319973468780518},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000921","descriptor_name":"Antibody-Producing Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006462","descriptor_name":"Hemolytic Plaque Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013587","descriptor_name":"Syphilis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013587","descriptor_name":"Syphilis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1453664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:2931353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2931353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:2398920779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2931353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1453664","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1453664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W158118877","https://openalex.org/W206541042","https://openalex.org/W336267493","https://openalex.org/W364820959","https://openalex.org/W1508046240","https://openalex.org/W1511596690","https://openalex.org/W1515554307","https://openalex.org/W1516606469","https://openalex.org/W1525919172","https://openalex.org/W1542504858","https://openalex.org/W1567003943","https://openalex.org/W1896325920","https://openalex.org/W1898793356","https://openalex.org/W1900399688","https://openalex.org/W1909717545","https://openalex.org/W1926410670","https://openalex.org/W1945575935","https://openalex.org/W1968118148","https://openalex.org/W1981178515","https://openalex.org/W1986676375","https://openalex.org/W2036675349","https://openalex.org/W2046648691","https://openalex.org/W2062335001","https://openalex.org/W2077746345","https://openalex.org/W2088381124","https://openalex.org/W2102178503","https://openalex.org/W2156700920","https://openalex.org/W2161977923","https://openalex.org/W2178967833","https://openalex.org/W2204340778","https://openalex.org/W2268986083","https://openalex.org/W2408030069","https://openalex.org/W2415707510","https://openalex.org/W2422264815","https://openalex.org/W2800652256","https://openalex.org/W4299682763"],"related_works":["https://openalex.org/W2062335001","https://openalex.org/W2102178503","https://openalex.org/W2327905741","https://openalex.org/W4313339441","https://openalex.org/W1508046240","https://openalex.org/W2204340778","https://openalex.org/W1628384779","https://openalex.org/W1965250215","https://openalex.org/W4319161606","https://openalex.org/W1897197775"],"abstract_inverted_index":{"We":[0],"have":[1],"studied":[2],"the":[3,6,25,34,69,82,85,88,93,96,108,115,123,129,134,145,187,192,209,235,248,257,278,298,307,311,323,326,359,385,394],"changes":[4,67],"in":[5,14,53,68,107,144,251,276,297,310,334,356],"lymph":[7,49,112,132,224,279,299,340,375],"nodes,":[8,113,133],"spleen":[9,70,109,130,282,308],"and":[10,45,61,74,110,131,141,215,230,239,265,281,292,339],"thymus":[11,89,249],"that":[12,245],"occur":[13],"inbred":[15],"LSH":[16],"Syrian":[17],"hamsters":[18,166,345,380],"infected":[19,39,165,223,344,379],"with":[20,285],"Treponema":[21],"pallidum":[22],"Bosnia":[23],"A,":[24],"causative":[26],"agent":[27],"of":[28,37,87,95,101,118,125,137,147,157,161,189,213,222,247,260,262,272,288,314,325,358,361,369,389],"endemic":[29],"syphilis,":[30],"as":[31,33,391],"well":[32],"B-cell":[35,267,295,318],"responses":[36,221,388],"these":[38],"animals":[40],"to":[41,56,167,173,196,227,351,353,383,393],"helper":[42,180,201,290],"T-cell":[43,181,202],"independent":[44,182],"dependent":[46,203],"antigens.":[47],"The":[48,98,159,219,367],"nodes":[50,280],"increased":[51,106,139,206,233],"significantly":[52],"weight":[54,71],"up":[55],"6":[57],"weeks":[58,156,212,238],"after":[59],"infection,":[60,315],"contained":[62],"viable":[63,76],"treponemes.":[64],"No":[65],"significant":[66],"were":[72,232,330,346],"observed,":[73],"no":[75],"treponemes":[77],"could":[78],"be":[79],"recovered":[80],"from":[81,164,306,343,378],"spleen.":[83],"However,":[84,191],"size":[86],"decreased":[90,121,142,217,240],"steadily":[91],"during":[92,122,208,234],"course":[94,124,188,324],"disease.":[97,327],"relative":[99,116,135],"number":[100,117,136],"Ig+":[102],"cells":[103,120,264,275,291,303],"(B":[104],"cells)":[105],"regional":[111],"whereas":[114,316],"T":[119,263,274,289,302,365],"infection.":[126,158,190],"In":[127],"both":[128,228,277],"macrophages":[138],"initially":[140],"thereafter":[143],"form":[146],"a":[148,152,169,179,200,286],"bell-shaped":[149],"curve":[150],"showing":[151],"peak":[153],"at":[154],"4-6":[155],"ability":[160,350],"splenic":[162,193,317,338,373],"lymphocytes":[163,226,342,377],"mount":[168],"primary":[170,386],"PFC":[171,194,220],"response":[172,195],"pneumococcal":[174],"polysaccharide":[175],"type":[176],"III":[177],"(SIII),":[178],"antigen,":[183,204],"was":[184,205,381],"elevated":[185],"throughout":[186,322],"sheep":[197],"erythrocytes":[198],"(SRBC),":[199],"only":[207,309],"first":[210,236],"4":[211,237],"infection":[214,253],"progressively":[216],"thereafter.":[218,241],"node":[225,341,376],"SIII":[229],"SRBC":[231,390],"These":[242,328],"data":[243],"suggested":[244],"atrophy":[246],"seen":[250],"syphilitic":[252],"is":[254],"accompanied":[255],"by":[256,333],"complex":[258],"losses":[259],"subsets":[261],"altered":[266],"functions.":[268],"An":[269],"early":[270],"loss":[271,287],"suppressor":[273,364],"occurs":[283],"concomitantly":[284],"heterologous":[293],"(treponema-unrelated)":[294],"functions":[296,319],"nodes.":[300],"Helper":[301],"are":[304],"lost":[305],"later":[312],"stages":[313],"remain":[320],"intact":[321],"findings":[329],"further":[331],"tested":[332],"vitro":[335],"methods":[336],"where":[337],"examined":[347],"for":[348],"their":[349],"respond":[352],"Con":[354,370],"A":[355,371],"terms":[357],"induction":[360],"antigen":[362],"non-specific":[363],"cells.":[366],"mixing":[368],"stimulated":[372],"or":[374],"unable":[382],"inhibit":[384],"antibody":[387],"compared":[392],"normal":[395],"control.(ABSTRACT":[396],"TRUNCATED":[397],"AT":[398],"400":[399],"WORDS)":[400]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}