{"id":"https://openalex.org/W2398897469","doi":null,"title":"Effects of glucocorticoids on the airways.","display_name":"Effects of glucocorticoids on the airways.","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2398897469","mag":"2398897469","pmid":"https://pubmed.ncbi.nlm.nih.gov/6291972"},"language":"en","primary_location":{"id":"pmid:6291972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6291972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of respiratory diseases. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014527713","display_name":"N Svedmyr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"N Svedmyr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014527713"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2042,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.91593659,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":"48","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/airway-immunology","display_name":"airway immunology","score":0.593999981880188},{"id":"https://openalex.org/keywords/lymphocyte-distribution","display_name":"lymphocyte distribution","score":0.7089999914169312},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9860000014305115},{"id":"https://openalex.org/keywords/capillary-permeability","display_name":"capillary permeability","score":0.6859999895095825},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/phospholipid-methylation","display_name":"phospholipid methylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.7839999794960022},{"id":"https://openalex.org/keywords/bronchospasm","display_name":"bronchospasm","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mast-cell-histamine-release","display_name":"mast cell histamine release","score":0.7059999704360962},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.7265470623970032},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6374545097351074},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6362546682357788},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6056175231933594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5793116092681885},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.4583198130130768},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44754257798194885},{"id":"https://openalex.org/C2778088044","wikidata":"https://www.wikidata.org/wiki/Q279330","display_name":"Bronchospasm","level":3,"score":0.41386714577674866},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36244985461235046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3206908106803894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2486831247806549},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22899511456489563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21690583229064941},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.14491692185401917},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12122559547424316},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6291972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6291972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of respiratory diseases. Supplement","raw_type":"Journal Article"},{"id":"mag:2398897469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6291972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007303093","https://openalex.org/W2113935480","https://openalex.org/W109519787","https://openalex.org/W560758800","https://openalex.org/W41633534","https://openalex.org/W4211175455","https://openalex.org/W1562742229","https://openalex.org/W3151419507","https://openalex.org/W1980209151","https://openalex.org/W228727514"],"abstract_inverted_index":{"Glucocorticoids":[0],"can":[1],"affect":[2],"every":[3],"stage":[4],"of":[5,16,29,38,51,67,78,84],"inflammatory":[6,33,120],"and":[7,14,19,25,53,105,113,119],"immunological":[8],"reactivity.":[9],"They":[10],"influence":[11],"the":[12,27,49,65,76,87,91,98],"movement":[13],"distribution":[15],"lymphocytes,":[17],"neutrophils":[18],"eosinophils":[20],"in":[21,90],"quite":[22],"low":[23],"concentrations":[24],"decrease":[26],"accumulation":[28],"these":[30,39],"cells":[31,40,54,112],"at":[32],"sites.":[34],"The":[35],"functional":[36],"capabilities":[37],"are":[41],"relatively":[42],"resistant":[43],"to":[44,63],"steroids.":[45],"Steroids":[46],"also":[47],"inhibit":[48],"leakage":[50],"fluid":[52],"from":[55,110],"capillary":[56],"beds.":[57],"Glucocorticosteroids":[58],"have":[59],"recently":[60],"been":[61],"shown":[62],"stimulate":[64],"synthesis":[66],"a":[68,82],"protein":[69],"called":[70],"lipomodulin":[71],"or":[72],"macrocortin,":[73],"which":[74],"inhibits":[75],"activity":[77],"phospholipase":[79],"A2.":[80],"As":[81],"consequence":[83],"this":[85],"effect":[86],"phospholipid":[88],"methylation":[89],"cell":[92],"membrane":[93],"is":[94,97],"inhibited,":[95],"as":[96,115,117],"arachidonic":[99],"acid":[100],"cascade.":[101],"This":[102],"decreases":[103],"neutrophil":[104],"macrophage":[106],"chemotaxis,":[107],"histamine":[108],"release":[109],"mast":[111],"basophils":[114],"well":[116],"bronchospasm":[118],"oedema":[121],"mediated":[122],"by":[123],"leukotrienes.":[124]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}