{"id":"https://openalex.org/W2398891060","doi":null,"title":"Viral sequence analysis of occult HBV infection and its reactivation in immunosuppressed patients.","display_name":"Viral sequence analysis of occult HBV infection and its reactivation in immunosuppressed patients.","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2398891060","mag":"2398891060","pmid":"https://pubmed.ncbi.nlm.nih.gov/23034265"},"language":"en","primary_location":{"id":"pmid:23034265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23034265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10447/77963","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049553822","display_name":"Donatella Ferraro","orcid":"https://orcid.org/0000-0003-0911-9289","observed_orcids":["https://orcid.org/0000-0003-0911-9289"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Ferraro","raw_affiliation_strings":["Dipartimento di Scienze per la Promozione della Salute - G. D Alessandro, University of Palermo, Palermo, Italy. dferraro@unipa.it","Dipartimento di Scienze per la Promozione della Salute - G. D Alessandro, University of Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze per la Promozione della Salute - G. D Alessandro, University of Palermo, Palermo, Italy. dferraro@unipa.it","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Dipartimento di Scienze per la Promozione della Salute - G. D Alessandro, University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079102494","display_name":"Paola Pizzillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Pizzillo","raw_affiliation_strings":["Biomedico di Medicina Interna e Specialistica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedico di Medicina Interna e Specialistica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049988349","display_name":"Noemi Urone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Urone","raw_affiliation_strings":["Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015240940","display_name":"Emilio Iannitto","orcid":"https://orcid.org/0000-0002-5044-5820","observed_orcids":["https://orcid.org/0000-0002-5044-5820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Iannitto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684562","display_name":"Antonio Crax\u00ec","orcid":"https://orcid.org/0000-0002-4480-9544","observed_orcids":["https://orcid.org/0000-0002-4480-9544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Craxi","raw_affiliation_strings":["Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037787383","display_name":"R. Di Stefano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Di Stefano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4277,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6274557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"26","issue":"3","first_page":"457","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/occult-hepatitis-b-infection","display_name":"occult hepatitis B infection","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hepatitis-b-reactivation","display_name":"HBV reactivation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9570000171661377},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/viral-heterogeneity","display_name":"viral heterogeneity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/quasispecies","display_name":"quasispecies","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hbv-genotypes","display_name":"HBV genotypes","score":0.671999990940094},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.699999988079071},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.9803353548049927},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.6977866888046265},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6915738582611084},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6625233888626099},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5983585119247437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4730500280857086},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4500562846660614},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4493643343448639},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4148789346218109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3566834330558777},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.21564853191375732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14869540929794312},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08743458986282349},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07361823320388794},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:23034265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23034265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unipa.it:10447/77963","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/77963","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2398891060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23034265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unipa.it:10447/77963","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/77963","pdf_url":null,"source":{"id":"https://openalex.org/S4306401065","display_name":"Nova Science Publishers (Nova Science Publishers, Inc.)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1975485577","https://openalex.org/W1991980917","https://openalex.org/W2003692477","https://openalex.org/W2015299231","https://openalex.org/W2026063973","https://openalex.org/W2038144993","https://openalex.org/W2061188212","https://openalex.org/W2080222370","https://openalex.org/W2089730478","https://openalex.org/W2124459409","https://openalex.org/W2127766015","https://openalex.org/W2144685518","https://openalex.org/W2151169883","https://openalex.org/W2159392789","https://openalex.org/W2165287314","https://openalex.org/W2172129515","https://openalex.org/W2331291155"],"related_works":["https://openalex.org/W2905890016","https://openalex.org/W2339815215","https://openalex.org/W2340295587","https://openalex.org/W1965268012","https://openalex.org/W2171827389","https://openalex.org/W2340752976","https://openalex.org/W2026421904","https://openalex.org/W2969688748","https://openalex.org/W2025283567","https://openalex.org/W1968195060"],"abstract_inverted_index":{"Mechanisms":[0],"associated":[1],"with":[2,11,32,70],"reactivation":[3,118],"of":[4,25,44,50,67,75,89,119,135,137,151,157],"hepatitis":[5],"B":[6],"virus":[7],"(HBV)":[8],"in":[9,105],"patients":[10,31,69,115],"occult":[12,51,167],"HBV":[13,52,54,158],"infection":[14],"(OBI)":[15],"remain":[16],"unclear.":[17],"In":[18],"some":[19],"cases":[20],"immunosuppression":[21,36],"is":[22],"an":[23],"enhancer":[24],"viral":[26,45,107],"replication.":[27],"However,":[28],"not":[29,161],"all":[30],"OBI":[33,71,79,144],"who":[34,116,123],"undergo":[35],"experience":[37],"reactivation.":[38,53,80,90],"This":[39],"study":[40],"explores":[41],"the":[42,64,87,106,129,138,142,148,152,164,178],"role":[43],"heterogeneity":[46],"as":[47],"a":[48,78,133],"determinant":[49],"genotype,":[55],"mutation":[56,111],"patterns":[57],"and":[58,96,121],"quasispecies":[59,130],"were":[60,83,102],"assessed":[61,85],"by":[62,177],"sequencing":[63],"PreS/S":[65],"region":[66],"16":[68],"undergoing":[72],"chemotherapy,":[73],"3":[74],"whom":[76],"experienced":[77],"The":[81,154],"latter":[82],"also":[84],"at":[86],"time":[88],"Phylogenetic":[91],"analysis":[92],"identified":[93],"low":[94],"nucleotide":[95],"amino":[97],"acid":[98],"diversity":[99],"rates.":[100],"There":[101],"no":[103],"differences":[104],"quasispecies,":[108],"or":[109],"common":[110],"patterns,":[112],"detected":[113],"between":[114],"underwent":[117],"OBI,":[120],"those":[122],"did":[124,160],"not.":[125],"Furthermore,":[126],"upon":[127],"reactivation,":[128],"evolved":[131],"towards":[132],"loss":[134],"most":[136],"variants":[139],"present":[140],"during":[141],"initial":[143],"stage,":[145],"probably":[146],"representing":[147],"fittest":[149],"version":[150],"virus.":[153],"genetic":[155],"variability":[156],"alone":[159],"account":[162],"for":[163],"transition":[165],"from":[166],"to":[168,173],"overt":[169],"infection,":[170],"which":[171],"appears":[172],"be":[174],"governed":[175],"principally":[176],"host":[179],"immune":[180],"response.":[181]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
