{"id":"https://openalex.org/W2398889972","doi":"https://doi.org/10.5966/sctm.2015-0224","title":"A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles","display_name":"A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles","publication_year":2016,"publication_date":"2016-05-23","ids":{"openalex":"https://openalex.org/W2398889972","doi":"https://doi.org/10.5966/sctm.2015-0224","mag":"2398889972","pmid":"https://pubmed.ncbi.nlm.nih.gov/27217344","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4996435"},"language":"en","primary_location":{"id":"doi:10.5966/sctm.2015-0224","doi":"https://doi.org/10.5966/sctm.2015-0224","is_oa":true,"landing_page_url":"https://doi.org/10.5966/sctm.2015-0224","pdf_url":"https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0224","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007783206","display_name":"Leslie Caron","orcid":"https://orcid.org/0000-0003-4118-2974","observed_orcids":["https://orcid.org/0000-0003-4118-2974"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leslie Caron","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078392854","display_name":"Devaki Kher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devaki Kher","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076864927","display_name":"Kian Leong Lee","orcid":"https://orcid.org/0000-0002-0443-2746","observed_orcids":["https://orcid.org/0000-0002-0443-2746"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kian Leong Lee","raw_affiliation_strings":["b Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030396522","display_name":"Robert McKernan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert McKernan","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035965285","display_name":"Biljana Dumevska","orcid":"https://orcid.org/0009-0007-5683-6762","observed_orcids":["https://orcid.org/0009-0007-5683-6762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Biljana Dumevska","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049650830","display_name":"Alejandro Hidalgo","orcid":"https://orcid.org/0000-0002-8395-7179","observed_orcids":["https://orcid.org/0000-0002-8395-7179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandro Hidalgo","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101419070","display_name":"Jia Li","orcid":"https://orcid.org/0000-0001-8360-3912","observed_orcids":["https://orcid.org/0000-0001-8360-3912"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["b Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008473414","display_name":"Henry He Yang","orcid":"https://orcid.org/0000-0002-1155-8216","observed_orcids":["https://orcid.org/0000-0002-1155-8216"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Henry Yang","raw_affiliation_strings":["b Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066187178","display_name":"Heather Main","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather Main","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Giulia Ferri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210091790","display_name":"Dulbecco Telethon Institute","ror":"https://ror.org/00f7kfd14","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210091790","https://openalex.org/I4210154366"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Ferri","raw_affiliation_strings":["c Dulbecco Telethon Institute and Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy","d Vita-Salute San Raffaele University, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Dulbecco Telethon Institute and Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210091790","https://openalex.org/I4210133214"]},{"raw_affiliation_string":"d Vita-Salute San Raffaele University, Milano, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013235773","display_name":"Lisa M. Petek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa M. Petek","raw_affiliation_strings":["e Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"e Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050720617","display_name":"Lorenz Poellinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277804","display_name":"Cancer Science Institute of Singapore","ror":"https://ror.org/03yky5015","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277804"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lorenz Poellinger","raw_affiliation_strings":["b Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036806498","display_name":"Daniel G. Miller","orcid":"https://orcid.org/0000-0002-5700-3048","observed_orcids":["https://orcid.org/0000-0002-5700-3048"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel G. Miller","raw_affiliation_strings":["e Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"e Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017092846","display_name":"Davide Gabellini","orcid":"https://orcid.org/0000-0002-3811-4121","observed_orcids":["https://orcid.org/0000-0002-3811-4121"]},"institutions":[{"id":"https://openalex.org/I4210091790","display_name":"Dulbecco Telethon Institute","ror":"https://ror.org/00f7kfd14","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210091790","https://openalex.org/I4210154366"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Gabellini","raw_affiliation_strings":["c Dulbecco Telethon Institute and Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Dulbecco Telethon Institute and Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210091790","https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050224699","display_name":"Uli Schmidt","orcid":"https://orcid.org/0000-0002-1757-3986","observed_orcids":["https://orcid.org/0000-0002-1757-3986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uli Schmidt","raw_affiliation_strings":["a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","f Genea Biocells US Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Genea Biocells Pty. Ltd., Sydney, New South Wales, Australia","institution_ids":[]},{"raw_affiliation_string":"f Genea Biocells US Inc., San Diego, California, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007783206"],"corresponding_institution_ids":[],"apc_list":{"value":2963,"currency":"USD","value_usd":2963},"apc_paid":{"value":2963,"currency":"USD","value_usd":2963},"fwci":3.8173,"has_fulltext":true,"cited_by_count":131,"citation_normalized_percentile":{"value":0.94924824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"9","first_page":"1145","last_page":"1161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.43380001187324524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/facioscapulohumeral-muscular-dystrophy","display_name":"facioscapulohumeral muscular dystrophy","score":1.0},{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/skeletal-muscle-differentiation","display_name":"skeletal muscle differentiation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.5080000162124634},{"id":"https://openalex.org/keywords/becker-muscular-dystrophy","display_name":"Becker muscular dystrophy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/oxidative-stress-response","display_name":"oxidative stress response","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2779981540","wikidata":"https://www.wikidata.org/wiki/Q1399182","display_name":"Facioscapulohumeral muscular dystrophy","level":3,"score":0.852660059928894},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8106467723846436},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.6024407744407654},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47639790177345276},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4261147379875183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4047139883041382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37985074520111084},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33625805377960205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31059393286705017},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25417834520339966},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2494335174560547},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.12893521785736084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11970096826553345}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020391","descriptor_name":"Muscular Dystrophy, Facioscapulohumeral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.5966/sctm.2015-0224","doi":"https://doi.org/10.5966/sctm.2015-0224","is_oa":true,"landing_page_url":"https://doi.org/10.5966/sctm.2015-0224","pdf_url":"https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0224","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4470177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4996435","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27217344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27217344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4996435","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4996435/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:acc0cb4ac8ae47ce9836e621e6d06fb8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/acc0cb4ac8ae47ce9836e621e6d06fb8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cells Translational Medicine, Vol 5, Iss 9, Pp 1145-1161 (2016)","raw_type":"article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/164151","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.5966/sctm.2015-0224","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.5966/sctm.2015-0224","doi":"https://doi.org/10.5966/sctm.2015-0224","is_oa":true,"landing_page_url":"https://doi.org/10.5966/sctm.2015-0224","pdf_url":"https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0224","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8909152623","display_name":"Epigenetic Modifiers of D4Z4 in Facioscapulohumeral Muscular Dystrophy (FSHD)","funder_award_id":"R01AR064197","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320311427","display_name":"FSHD Global Research Foundation","ror":"https://ror.org/053w93n68"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2398889972.pdf","grobid_xml":"https://content.openalex.org/works/W2398889972.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1514532595","https://openalex.org/W1540333271","https://openalex.org/W1774217609","https://openalex.org/W1953958400","https://openalex.org/W1966805460","https://openalex.org/W1973403961","https://openalex.org/W1974283636","https://openalex.org/W1980673678","https://openalex.org/W1985659366","https://openalex.org/W1990897270","https://openalex.org/W1996577262","https://openalex.org/W1997058353","https://openalex.org/W1997102401","https://openalex.org/W2002257667","https://openalex.org/W2003975348","https://openalex.org/W2008881299","https://openalex.org/W2012799716","https://openalex.org/W2012932405","https://openalex.org/W2014889497","https://openalex.org/W2015703333","https://openalex.org/W2018380248","https://openalex.org/W2023607197","https://openalex.org/W2026074925","https://openalex.org/W2026556066","https://openalex.org/W2028134396","https://openalex.org/W2037293161","https://openalex.org/W2037761873","https://openalex.org/W2038856813","https://openalex.org/W2039010203","https://openalex.org/W2048408742","https://openalex.org/W2051402951","https://openalex.org/W2055787369","https://openalex.org/W2060326689","https://openalex.org/W2063135302","https://openalex.org/W2072832813","https://openalex.org/W2087416714","https://openalex.org/W2088714421","https://openalex.org/W2091005500","https://openalex.org/W2095322574","https://openalex.org/W2097391561","https://openalex.org/W2098050789","https://openalex.org/W2103091788","https://openalex.org/W2113144753","https://openalex.org/W2113267381","https://openalex.org/W2116578012","https://openalex.org/W2127310310","https://openalex.org/W2132635541","https://openalex.org/W2132673351","https://openalex.org/W2136204966","https://openalex.org/W2145074423","https://openalex.org/W2150114997","https://openalex.org/W2150926065","https://openalex.org/W2153811661","https://openalex.org/W2157037875","https://openalex.org/W2167135407","https://openalex.org/W2170064963","https://openalex.org/W2171806782","https://openalex.org/W3190848106","https://openalex.org/W4244573300"],"related_works":["https://openalex.org/W4414801163","https://openalex.org/W4404470272","https://openalex.org/W2754421462","https://openalex.org/W4205872072","https://openalex.org/W2957134350","https://openalex.org/W4294225706","https://openalex.org/W3216667905","https://openalex.org/W2897358506","https://openalex.org/W4412893510","https://openalex.org/W1996142400"],"abstract_inverted_index":{"UNLABELLED:":[0],":":[1],"Facioscapulohumeral":[2],"muscular":[3,126,166,207,221],"dystrophy":[4,127,222],"(FSHD)":[5],"represents":[6,211],"a":[7,51,69,149,220],"major":[8],"unmet":[9],"clinical":[10],"need":[11],"arising":[12],"from":[13,94,198],"the":[14,34,100,111,160,212],"progressive":[15],"weakness":[16],"and":[17,59,107,124,129,141,155,174,191,201,229],"atrophy":[18],"of":[19,24,33,54,110,162],"skeletal":[20,55,187],"muscles.":[21],"The":[22],"dearth":[23],"adequate":[25],"experimental":[26],"models":[27],"has":[28],"severely":[29],"hampered":[30],"our":[31],"understanding":[32],"disease.":[35],"To":[36],"date,":[37],"no":[38],"treatment":[39],"is":[40,224],"available":[41],"for":[42,152,165,219,226],"FSHD.":[43,115],"Human":[44],"embryonic":[45,200],"stem":[46,183,215],"cells":[47,57,184,189],"(hESCs)":[48],"potentially":[49],"represent":[50],"renewable":[52],"source":[53],"muscle":[56,188],"(SkMCs)":[58,190],"provide":[60],"an":[61,172],"alternative":[62],"to":[63,73,179],"invasive":[64],"patient":[65],"biopsies.":[66],"We":[67],"developed":[68],"scalable":[70,176],"monolayer":[71,177],"system":[72,178],"differentiate":[74,180],"hESCs":[75],"into":[76,186],"mature":[77],"SkMCs":[78,92,196],"within":[79],"26":[80],"days,":[81],"without":[82],"cell":[83,135,142],"sorting":[84],"or":[85],"genetic":[86],"manipulation.":[87],"Here":[88],"we":[89],"show":[90],"that":[91,223],"derived":[93,197],"FSHD1-affected":[95],"hESC":[96],"lines":[97],"exclusively":[98],"express":[99],"FSHD":[101,154],"pathogenic":[102],"marker":[103],"double":[104],"homeobox":[105],"4":[106],"exhibit":[108],"some":[109],"defects":[112],"reported":[113],"in":[114,134,159,195],"FSHD1":[116],"myotubes":[117],"are":[118],"thinner":[119],"when":[120],"compared":[121],"with":[122,205],"unaffected":[123],"Becker":[125],"myotubes,":[128],"differentially":[130],"regulate":[131],"genes":[132],"involved":[133],"cycle":[136],"control,":[137],"oxidative":[138],"stress":[139],"response,":[140],"adhesion.":[143],"This":[144,169,209],"cellular":[145,217],"model":[146,218],"will":[147,156],"be":[148],"powerful":[150],"tool":[151],"studying":[153],"ultimately":[157],"assist":[158],"development":[161],"effective":[163],"treatments":[164],"dystrophies.":[167],"SIGNIFICANCE:":[168],"work":[170],"describes":[171],"efficient":[173],"highly":[175],"human":[181,214],"pluripotent":[182],"(hPSCs)":[185],"demonstrates":[192],"disease-specific":[193],"phenotypes":[194],"both":[199],"induced":[202],"hPSCs":[203],"affected":[204],"facioscapulohumeral":[206],"dystrophy.":[208],"study":[210],"first":[213],"cell-based":[216],"suitable":[225],"high-throughput":[227],"screening":[228],"drug":[230],"development.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}