{"id":"https://openalex.org/W2398884288","doi":null,"title":"Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure.","display_name":"Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2398884288","mag":"2398884288","pmid":"https://pubmed.ncbi.nlm.nih.gov/27179575"},"language":"en","primary_location":{"id":"pmid:27179575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27179575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046501529","display_name":"Dana Dlouh\u00e1","orcid":"https://orcid.org/0000-0001-7167-1336","observed_orcids":["https://orcid.org/0000-0001-7167-1336"]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Dana Dlouha","raw_affiliation_strings":["Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048434957","display_name":"Jevgenija Vym\u011btalov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jevgenija Vymetalova","raw_affiliation_strings":["Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105540704","display_name":"Ivan M\u00e1lek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ivan Malek","raw_affiliation_strings":["Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091695483","display_name":"Jaroslav Alois Hubacek","orcid":"https://orcid.org/0000-0001-6537-1353","observed_orcids":["https://orcid.org/0000-0001-6537-1353"]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jaroslav A Hubacek","raw_affiliation_strings":["Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210127955"],"apc_list":null,"apc_paid":null,"fwci":0.1378,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49040512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"2","first_page":"124","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9309999942779541},{"id":"https://openalex.org/keywords/leukocyte-telomere-length","display_name":"leukocyte telomere length","score":0.9470000267028809},{"id":"https://openalex.org/keywords/aortic-tissue","display_name":"aortic tissue","score":0.9300000071525574},{"id":"https://openalex.org/keywords/end-stage-heart-failure","display_name":"end-stage heart failure","score":0.8460000157356262},{"id":"https://openalex.org/keywords/biological-aging","display_name":"biological aging","score":0.8159999847412109},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9420589208602905},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.8184001445770264},{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.7156149744987488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.546356201171875},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.49907350540161133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4782473146915436},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3726113438606262},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33561214804649353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32579052448272705},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32566148042678833},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2759414315223694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2733241021633148},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.09077796339988708}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:27179575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27179575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:2398884288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27179575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2742758254","https://openalex.org/W2061088310","https://openalex.org/W2055541885","https://openalex.org/W2944277143","https://openalex.org/W2144539159","https://openalex.org/W3143907208","https://openalex.org/W2765455720","https://openalex.org/W2327568272","https://openalex.org/W7166474908","https://openalex.org/W2045483603"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Telomeres":[1],"are":[2],"repetitive":[3],"non-coding":[4],"DNA":[5],"sequences":[6],"on":[7],"the":[8,90],"ends":[9],"of":[10,47,92,120,153],"eukaryotic":[11],"chromosomes.":[12],"Relative":[13,72],"leukocyte":[14,59,131],"telomere":[15,54,73,134],"length":[16,55,74],"(LrTL)":[17],"is":[18,146],"considered":[19],"to":[20,148],"reflect":[21,32],"biological":[22,48,154],"ageing":[23,155],"and":[24,38,58,103,114,141],"fitness.":[25],"Therefore,":[26],"we":[27],"examined":[28],"whether":[29,39],"LrTL":[30,84,101,113,140,145],"would":[31],"rTL":[33],"in":[34,56,156],"aortic":[35,57,133],"tissue":[36],"(ArTL)":[37],"it":[40],"could":[41],"be":[42,149],"used":[43],"as":[44],"a":[45,78,106],"marker":[46],"heart":[49,63,93,125],"age.":[50],"DESIGN:":[51],"We":[52],"analysed":[53],"samples":[60],"from":[61],"73":[62],"recipients":[64],"(63":[65],"males,":[66],"10":[67],"females;":[68],"age":[69,91,119],"52.2\u00b111.7":[70],"years).":[71],"was":[75,97,105,127],"measured":[76],"using":[77],"quantitative":[79],"PCR-based":[80],"method.":[81],"RESULTS:":[82],"Neither":[83],"nor":[85],"ArTL":[86,96,115,142],"correlated":[87],"significantly":[88],"with":[89,122,130],"recipients.":[94],"Mean":[95],"slightly":[98],"shorter":[99],"than":[100],"(p=0.06)":[102],"there":[104],"slight":[107],"but":[108],"significant":[109],"inverse":[110,137],"correlation":[111,138],"between":[112,139],"(p=0.019).":[116],"CONCLUSIONS:":[117],"The":[118],"patients":[121],"end":[123],"stage":[124],"failure":[126],"not":[128],"associated":[129],"or":[132],"length.":[135],"An":[136],"suggests":[143],"that":[144],"unlikely":[147],"an":[150],"important":[151],"predictor":[152],"these":[157],"patients.":[158]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}