{"id":"https://openalex.org/W2398878044","doi":null,"title":"Antipsychotic-like effect of minocycline in a rat model.","display_name":"Antipsychotic-like effect of minocycline in a rat model.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2398878044","mag":"2398878044","pmid":"https://pubmed.ncbi.nlm.nih.gov/25419368","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238471"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4238471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238471","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078555472","display_name":"Recep Dokuyucu","orcid":"https://orcid.org/0000-0001-6837-3477","observed_orcids":["https://orcid.org/0000-0001-6837-3477"]},"institutions":[{"id":"https://openalex.org/I46000314","display_name":"Mustafa Kemal University","ror":"https://ror.org/056hcgc41","country_code":"TR","type":"education","lineage":["https://openalex.org/I46000314"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Recep Dokuyucu","raw_affiliation_strings":["Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey","institution_ids":["https://openalex.org/I46000314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065755314","display_name":"Mehmet Hanifi Koka\u00e7ya","orcid":"https://orcid.org/0000-0002-2961-7229","observed_orcids":["https://orcid.org/0000-0002-2961-7229"]},"institutions":[{"id":"https://openalex.org/I46000314","display_name":"Mustafa Kemal University","ror":"https://ror.org/056hcgc41","country_code":"TR","type":"education","lineage":["https://openalex.org/I46000314"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hanifi Kokacya","raw_affiliation_strings":["Department of Psychiatry, Medical Faculty, Mustafa Kemal University Hatay, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Medical Faculty, Mustafa Kemal University Hatay, Turkey","institution_ids":["https://openalex.org/I46000314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011316380","display_name":"Sema \u0130nan\u0131r","orcid":"https://orcid.org/0000-0002-3136-0741","observed_orcids":["https://orcid.org/0000-0002-3136-0741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sema Inanir","raw_affiliation_strings":["Department of Psychiatry, Governor Recep Yazicioglu Mental Health and Disease Hospital Tokat, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Governor Recep Yazicioglu Mental Health and Disease Hospital Tokat, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107772855","display_name":"\u00dcmit Sertan \u00c7\u00f6po\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46000314","display_name":"Mustafa Kemal University","ror":"https://ror.org/056hcgc41","country_code":"TR","type":"education","lineage":["https://openalex.org/I46000314"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Umit Sertan Copoglu","raw_affiliation_strings":["Department of Psychiatry, Medical Faculty, Mustafa Kemal University Hatay, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Medical Faculty, Mustafa Kemal University Hatay, Turkey","institution_ids":["https://openalex.org/I46000314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014161241","display_name":"Oytun Erba\u015f","orcid":"https://orcid.org/0000-0001-5427-8428","observed_orcids":["https://orcid.org/0000-0001-5427-8428"]},"institutions":[{"id":"https://openalex.org/I238144855","display_name":"Tokat Gaziosmanpa\u015fa \u00dcniversitesi","ror":"https://ror.org/01rpe9k96","country_code":"TR","type":"education","lineage":["https://openalex.org/I238144855"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Oytun Erbas","raw_affiliation_strings":["Department of Psychiatry, Medical Faculty, Gaziosmanpasa University Tokat, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Medical Faculty, Gaziosmanpasa University Tokat, Turkey","institution_ids":["https://openalex.org/I238144855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5028,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81405247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"10","first_page":"3354","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":1.0},{"id":"https://openalex.org/keywords/antipsychotic-effects","display_name":"antipsychotic effects","score":0.828000009059906},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apomorphine-induced-stereotypy","display_name":"apomorphine-induced stereotypy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6190000176429749},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9509999752044678},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tetracycline-antibiotics","display_name":"tetracycline antibiotics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adjunctive-antipsychotic-therapy","display_name":"adjunctive antipsychotic therapy","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.9896038770675659},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.7714740037918091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.770171046257019},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6900136470794678},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6485317945480347},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6438101530075073},{"id":"https://openalex.org/C2779459141","wikidata":"https://www.wikidata.org/wiki/Q1198115","display_name":"Stereotypy","level":4,"score":0.5482927560806274},{"id":"https://openalex.org/C2910183285","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Isotonic saline","level":2,"score":0.5450068712234497},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5194963216781616},{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.4732033610343933},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3926194906234741},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3569418787956238},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3128911852836609},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2584780752658844},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.21125581860542297},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.17603173851966858},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15785536170005798},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.1095682680606842},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4238471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:25419368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25419368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:2398878044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25419368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4238471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4238471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W45776812","https://openalex.org/W106733242","https://openalex.org/W1484484684","https://openalex.org/W1968228641","https://openalex.org/W1980049394","https://openalex.org/W1983181787","https://openalex.org/W1983310681","https://openalex.org/W1987593166","https://openalex.org/W1991262780","https://openalex.org/W1991910040","https://openalex.org/W1992281320","https://openalex.org/W1995716681","https://openalex.org/W2002519510","https://openalex.org/W2003869950","https://openalex.org/W2003888150","https://openalex.org/W2016439339","https://openalex.org/W2025181958","https://openalex.org/W2025240330","https://openalex.org/W2026522842","https://openalex.org/W2050476288","https://openalex.org/W2057476473","https://openalex.org/W2065189444","https://openalex.org/W2066738717","https://openalex.org/W2067025220","https://openalex.org/W2067335226","https://openalex.org/W2070947242","https://openalex.org/W2071727158","https://openalex.org/W2076084115","https://openalex.org/W2077136896","https://openalex.org/W2080154281","https://openalex.org/W2082148717","https://openalex.org/W2084588595","https://openalex.org/W2091456872","https://openalex.org/W2096634542","https://openalex.org/W2099576957","https://openalex.org/W2099949127","https://openalex.org/W2121123285","https://openalex.org/W2121697466","https://openalex.org/W2124859215","https://openalex.org/W2135138585","https://openalex.org/W2159126784","https://openalex.org/W2408490779","https://openalex.org/W4407196861"],"related_works":["https://openalex.org/W2025181958","https://openalex.org/W2028834285","https://openalex.org/W2003888150","https://openalex.org/W2003869950","https://openalex.org/W2253366143","https://openalex.org/W2067335226","https://openalex.org/W2211976095","https://openalex.org/W1989071619","https://openalex.org/W2121123285","https://openalex.org/W2050476288"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Tetracycline":[1],"antibiotic":[2],"drug":[3],"minocycline":[4,37,71,107,136],"has":[5,12,137],"strongly":[6],"neuroprotective":[7],"and":[8,22,38,52,73,143,160],"anti-inflammatory":[9],"effects.":[10],"Minocycline":[11,122,180],"also":[13,123],"remarkable":[14],"brain":[15,53],"tissue":[16],"penetration,":[17],"is":[18,181],"clinically":[19],"entirely":[20],"tolerated":[21],"properly":[23],"absorbed":[24],"when":[25],"taken":[26],"orally.":[27],"In":[28],"our":[29],"study,":[30],"we":[31],"class":[32],"with":[33,70,118,177],"the":[34,46,110,116,125],"effects":[35,139,189],"of":[36,63,106,151,172,183],"chlorpromazine,":[39],"a":[40,129,191],"conventional":[41],"antipsychotic":[42,152],"drug,":[43],"by":[44],"evaluating":[45],"novelty-induced":[47],"rearing,":[48],"apomorphine-induced":[49],"stereotypic":[50],"behavior,":[51],"MDA":[54],"levels":[55],"in":[56,113,128,166],"rats.":[57],"MATERIALS":[58],"AND":[59],"METHODS:":[60],"Four":[61],"groups":[62],"rat":[64],"(n":[65],"=":[66],"7)":[67],"were":[68],"applied":[69,95],"(50":[72],"100":[74],"mg/kg,":[75,79,92],"i.p.),":[76,80],"chlorpromazine":[77,119],"(1":[78,84],"or":[81,174,193],"isotonic":[82],"saline":[83],"mL/kg,":[85],"i.p.).":[86],"One":[87],"hour":[88],"later,":[89],"apomorphine":[90],"(2":[91],"s.c.)":[93],"was":[94,120],"to":[96,148],"each":[97],"rat.":[98],"RESULT:":[99],"Our":[100],"results":[101],"showed":[102],"that":[103,135],"both":[104],"doses":[105],"significantly":[108],"decreased":[109,124],"rearing":[111,141],"behavior":[112,142],"rats,":[114],"whereas":[115],"decrease":[117],"higher.":[121],"stereotypy":[126],"scores":[127],"dose-dependent":[130],"manner.":[131],"CONCLUSION:":[132],"We":[133],"concluded":[134],"beneficial":[138],"on":[140,169],"stereotypy,":[144],"which":[145],"are":[146],"accepted":[147],"be":[149,164],"indicators":[150],"effect.":[153],"Taken":[154],"together,":[155],"minocycline,":[156],"as":[157,190],"an":[158,194],"anti-oxidant":[159],"cytoprotective":[161],"agent,":[162],"can":[163],"useful":[165],"neuroprotection":[167],"especially":[168],"early":[170],"stages":[171],"psychosis":[173],"prepsychotic":[175],"patients":[176],"insignificant":[178],"symptoms.":[179],"worthy":[182],"being":[184],"investigated":[185],"for":[186],"its":[187],"anti-psychotic":[188],"primary":[192],"adjunctive":[195],"drug.":[196]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
