{"id":"https://openalex.org/W2398875792","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g716","title":"Nerve growth factor promotes neurite outgrowth in guinea pig myenteric plexus ganglia","display_name":"Nerve growth factor promotes neurite outgrowth in guinea pig myenteric plexus ganglia","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2398875792","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g716","mag":"2398875792","pmid":"https://pubmed.ncbi.nlm.nih.gov/7943336"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1994.267.4.g716","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g716","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1994.267.4.g716","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109110150","display_name":"M. W. Mulholland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. W. Mulholland","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046547291","display_name":"Gail L. Romanchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Romanchuk","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089737043","display_name":"Kathleen M. Lally","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Lally","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030459924","display_name":"Diane M. Simeone","orcid":"https://orcid.org/0000-0001-5142-3087","observed_orcids":["https://orcid.org/0000-0001-5142-3087"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. M. Simeone","raw_affiliation_strings":["Department of Surgery, University of Michigan, Ann Arbor48109-0331"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Michigan, Ann Arbor48109-0331","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.2388,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.45218873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"267","issue":"4","first_page":"G716","last_page":"G722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":1.0},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9950000047683716},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.9950000047683716},{"id":"https://openalex.org/keywords/enteric-nervous-system-development","display_name":"enteric nervous system development","score":0.8629999756813049},{"id":"https://openalex.org/keywords/map2","display_name":"MAP2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.9146410822868347},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.8866075277328491},{"id":"https://openalex.org/C2776907353","wikidata":"https://www.wikidata.org/wiki/Q1890233","display_name":"Myenteric plexus","level":3,"score":0.7757591009140015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6082236766815186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6065508127212524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5787081718444824},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.5327287912368774},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4865356981754303},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.26829764246940613},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15578767657279968},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14628508687019348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1229894757270813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08873602747917175},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005724","descriptor_name":"Ganglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009197","descriptor_name":"Myenteric Plexus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1994.267.4.g716","doi":"https://doi.org/10.1152/ajpgi.1994.267.4.g716","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1994.267.4.g716","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:7943336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7943336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3637113118","display_name":"STUDIES OF GASTROINTESTINAL AUTONOMIC DYSFUNCTION","funder_award_id":"R01DK041204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007161156","https://openalex.org/W1971366797","https://openalex.org/W2004826106","https://openalex.org/W2415060193","https://openalex.org/W2414602931","https://openalex.org/W2046223223","https://openalex.org/W1567534087","https://openalex.org/W2115331336","https://openalex.org/W7097697319","https://openalex.org/W132440416"],"abstract_inverted_index":{"Nerve":[0],"growth":[1],"factor":[2],"(NGF)":[3],"has":[4],"important":[5],"developmental":[6],"actions":[7],"in":[8,36,40,50,93,169],"both":[9,94],"central":[10],"and":[11,57,114],"peripheral":[12],"nervous":[13],"systems.":[14],"Primary":[15],"cultures":[16],"of":[17,30,43,83,118,124,163],"neonatal":[18],"guinea":[19],"pig":[20],"myenteric":[21],"plexus":[22],"ganglia":[23,172],"were":[24,141,157],"used":[25],"to":[26,32,121],"examine":[27],"the":[28,41],"ability":[29],"NGF":[31,84,89,125,164,166],"stimulate":[33,174],"morphological":[34,175],"development":[35],"enteric":[37,119,171],"neurons.":[38],"NGF,":[39,107],"presence":[42],"a":[44],"serum-free":[45],"medium,":[46],"produced":[47],"dose-dependent":[48],"increases":[49,92],"neurite":[51,67,95,115],"density,":[52],"significant":[53],"at":[54,59,73,79,148,160],"1":[55,74],"ng/ml":[56,61],"maximal":[58,77],"100":[60,80],"(4.5-fold":[62],"increase":[63],"vs.":[64],"control).":[65],"Maximum":[66],"length":[68],"was":[69,128],"also":[70,129],"significantly":[71],"increased":[72,132,142,158],"ng/ml,":[75],"with":[76,87,131],"effects":[78],"ng/ml.":[81],"Coincubation":[82],"(50":[85],"ng/ml)":[86,127],"monoclonal":[88],"antibodies":[90],"abolished":[91],"density":[96],"(128":[97],"+/-":[98,104,109,144],"19":[99,105],"processes/mm":[100],"for":[101,106,111,135,153],"control,":[102],"369":[103],"183":[108],"28":[110],"NGF+monoclonal":[112],"antibodies)":[113],"length.":[116],"Exposure":[117],"neurons":[120],"low":[122],"concentrations":[123],"(1":[126],"associated":[130],"mRNA":[133,139,151],"levels":[134,140,152],"cytoskeletal":[136],"genes.":[137],"alpha-Tubulin":[138],"3.9":[143],"0.7":[145],"times":[146],"basal":[147],"48":[149,161],"h.":[150],"microtubule-associated":[154],"protein":[155],"2":[156],"threefold":[159],"h":[162],"incubation.":[165],"demonstrates":[167],"activities":[168],"cultured":[170],"that":[173],"development.":[176]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}