{"id":"https://openalex.org/W2398778167","doi":null,"title":"The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis","display_name":"The Impact Of Folate Restriction On Cancer And Aging: A Mechanistic Analysis","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2398778167","mag":"2398778167"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2427","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1428","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066764553","display_name":"Safa Beydoun","orcid":"https://orcid.org/0000-0001-8068-3953","observed_orcids":["https://orcid.org/0000-0001-8068-3953"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Safa Beydoun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8068-3953","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066764553"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.5034000277519226,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.878000020980835},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.7599999904632568},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.8330000042915344},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.7419999837875366},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44637003540992737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25702792406082153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22041833400726318}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2427","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1428","pdf_url":null,"source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},{"id":"mag:2398778167","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=2427&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W99804092","https://openalex.org/W120696217","https://openalex.org/W137678390","https://openalex.org/W152464472","https://openalex.org/W183423686","https://openalex.org/W1523543948","https://openalex.org/W1527555853","https://openalex.org/W1556460728","https://openalex.org/W1632132781","https://openalex.org/W1635937771","https://openalex.org/W1660351574","https://openalex.org/W1901983160","https://openalex.org/W1918117223","https://openalex.org/W1933788686","https://openalex.org/W1939738859","https://openalex.org/W1965980060","https://openalex.org/W1970341067","https://openalex.org/W1970608967","https://openalex.org/W1971997637","https://openalex.org/W1973749169","https://openalex.org/W1976570855","https://openalex.org/W1979895833","https://openalex.org/W1979942764","https://openalex.org/W1980549694","https://openalex.org/W1984479597","https://openalex.org/W1990374747","https://openalex.org/W1993410997","https://openalex.org/W1993844857","https://openalex.org/W2001399616","https://openalex.org/W2006559495","https://openalex.org/W2007215370","https://openalex.org/W2007711341","https://openalex.org/W2008982730","https://openalex.org/W2009176412","https://openalex.org/W2010238890","https://openalex.org/W2014892893","https://openalex.org/W2018290536","https://openalex.org/W2019240387","https://openalex.org/W2019502784","https://openalex.org/W2021469756","https://openalex.org/W2022051404","https://openalex.org/W2027425825","https://openalex.org/W2027523943","https://openalex.org/W2027665192","https://openalex.org/W2028480534","https://openalex.org/W2029030998","https://openalex.org/W2034013480","https://openalex.org/W2036045327","https://openalex.org/W2036781838","https://openalex.org/W2043223000","https://openalex.org/W2043445973","https://openalex.org/W2045201133","https://openalex.org/W2048376025","https://openalex.org/W2048994040","https://openalex.org/W2049300040","https://openalex.org/W2054530178","https://openalex.org/W2055674514","https://openalex.org/W2058881502","https://openalex.org/W2059876839","https://openalex.org/W2060455661","https://openalex.org/W2064405437","https://openalex.org/W2064414056","https://openalex.org/W2065195395","https://openalex.org/W2065197926","https://openalex.org/W2068397106","https://openalex.org/W2069930390","https://openalex.org/W2073701988","https://openalex.org/W2073925042","https://openalex.org/W2076308178","https://openalex.org/W2077612844","https://openalex.org/W2077834313","https://openalex.org/W2080094749","https://openalex.org/W2080470282","https://openalex.org/W2082603625","https://openalex.org/W2084822857","https://openalex.org/W2089594231","https://openalex.org/W2090747035","https://openalex.org/W2090803942","https://openalex.org/W2091381826","https://openalex.org/W2093165226","https://openalex.org/W2094677226","https://openalex.org/W2095886387","https://openalex.org/W2098537038","https://openalex.org/W2098711785","https://openalex.org/W2102558232","https://openalex.org/W2102749034","https://openalex.org/W2103277487","https://openalex.org/W2103938092","https://openalex.org/W2103953940","https://openalex.org/W2105269264","https://openalex.org/W2107060734","https://openalex.org/W2109870340","https://openalex.org/W2110016941","https://openalex.org/W2114758163","https://openalex.org/W2115568781","https://openalex.org/W2115820946","https://openalex.org/W2120934046","https://openalex.org/W2122636853","https://openalex.org/W2125609688","https://openalex.org/W2127063807","https://openalex.org/W2128016549","https://openalex.org/W2129072484","https://openalex.org/W2134461097","https://openalex.org/W2136125035","https://openalex.org/W2137458142","https://openalex.org/W2139571983","https://openalex.org/W2139919426","https://openalex.org/W2141671261","https://openalex.org/W2141716092","https://openalex.org/W2146374257","https://openalex.org/W2148095569","https://openalex.org/W2150763392","https://openalex.org/W2151351671","https://openalex.org/W2152101492","https://openalex.org/W2152289580","https://openalex.org/W2152839556","https://openalex.org/W2153442288","https://openalex.org/W2153607816","https://openalex.org/W2155098040","https://openalex.org/W2156003677","https://openalex.org/W2158258051","https://openalex.org/W2159014254","https://openalex.org/W2159314413","https://openalex.org/W2160980311","https://openalex.org/W2162474114","https://openalex.org/W2162481695","https://openalex.org/W2162895146","https://openalex.org/W2163583831","https://openalex.org/W2164111750","https://openalex.org/W2168104516","https://openalex.org/W2171154355","https://openalex.org/W2172162633","https://openalex.org/W2172465900","https://openalex.org/W2335824872","https://openalex.org/W2415536597","https://openalex.org/W2418405025","https://openalex.org/W2442607017","https://openalex.org/W2764507256"],"related_works":["https://openalex.org/W7037395599","https://openalex.org/W4400916915","https://openalex.org/W4390813055","https://openalex.org/W7046287829","https://openalex.org/W3169496947","https://openalex.org/W2066638714","https://openalex.org/W2120462742","https://openalex.org/W2294999713","https://openalex.org/W2491998655","https://openalex.org/W2577381132"],"abstract_inverted_index":{"Aging":[0],"is":[1,79],"a":[2,40,44,71,110],"multifactorial":[3],"process":[4,38],"associated":[5,24],"with":[6],"alterations":[7],"in":[8,20,31,53,81],"several":[9],"physiological":[10],"functions.":[11],"It":[12],"increases":[13],"susceptibility":[14],"to":[15,47,62,89,114],"disease":[16],"and":[17,65,84,117,125],"ultimately":[18],"results":[19],"mortality.":[21],"Since":[22],"the":[23,32,36,98,126],"diseases":[25],"of":[26],"aging":[27,37,64],"are":[28],"highly":[29],"prevalent":[30],"geriatric":[33],"population,":[34],"targeting":[35],"as":[39,109],"whole":[41],"may":[42],"provide":[43],"better":[45],"way":[46],"delay":[48,63,90],"these":[49],"age":[50,66],"related":[51,67],"diseases,":[52],"turn":[54],"delaying":[55],"aging.":[56,91],"Various":[57],"interventions":[58,93],"have":[59],"been":[60],"shown":[61,88],"diseases.":[68],"They":[69],"impact":[70],"major":[72],"nutrient":[73],"sensing":[74],"pathway,":[75],"mTOR.":[76],"mTOR":[77,127],"signaling":[78,128],"altered":[80],"many":[82],"cancers":[83],"its":[85],"downregulation":[86],"was":[87],"Other":[92],"extend":[94,115],"lifespan":[95,116],"by":[96],"altering":[97],"one":[99,122],"carbon":[100,123],"metabolism.":[101],"In":[102],"this":[103],"study,":[104],"we":[105],"present":[106],"folate":[107],"restriction":[108],"possible":[111],"nutritional":[112],"intervention":[113],"improve":[118],"health":[119],"span":[120],"impacting":[121],"metabolism":[124],"pathway.":[129]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
