{"id":"https://openalex.org/W2398726495","doi":null,"title":"Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: production and characterization.","display_name":"Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: production and characterization.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2398726495","mag":"2398726495","pmid":"https://pubmed.ncbi.nlm.nih.gov/2805416","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1534587"},"language":"en","primary_location":{"id":"pmid:2805416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2805416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1534587/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078288539","display_name":"Ingrid Randen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Randen","raw_affiliation_strings":["Institute of Immunology and Rheumatology, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Rheumatology, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021483377","display_name":"Thompson Km","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111457916","display_name":"Jacob B. Natvig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Natvig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110288722","display_name":"\u00d8ystein F\u00f8rre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O F\u00f8rre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053317845","display_name":"K. Waalen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Waalen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.6145,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.96162088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"78","issue":"1","first_page":"13","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9580000042915344},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.9110000133514404},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.6980000138282776},{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.9259999990463257},{"id":"https://openalex.org/keywords/kappa-and-lambda-light-chains","display_name":"kappa and lambda light chains","score":0.703000009059906},{"id":"https://openalex.org/keywords/igg-allotypes","display_name":"IgG allotypes","score":0.6620000004768372},{"id":"https://openalex.org/keywords/polyreactivity","display_name":"polyreactivity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/polyarticular-juvenile-rheumatoid-arthritis","display_name":"polyarticular juvenile rheumatoid arthritis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.7385278344154358},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7142614722251892},{"id":"https://openalex.org/C2776194381","wikidata":"https://www.wikidata.org/wiki/Q3965271","display_name":"Subclass","level":3,"score":0.6912478804588318},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6603024005889893},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.643120288848877},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5267027020454407},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.5213821530342102},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5192632675170898},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.48133835196495056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4230985641479492},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4081638753414154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.353476345539093},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.1382625699043274}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007129","descriptor_name":"Immunoglobulin Gm Allotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:2805416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2805416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1534587","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1534587/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"mag:2398726495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2805416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1534587","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1534587/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W9703251","https://openalex.org/W193289982","https://openalex.org/W1509021113","https://openalex.org/W1509307817","https://openalex.org/W1530090933","https://openalex.org/W1966154901","https://openalex.org/W1969235372","https://openalex.org/W1975570246","https://openalex.org/W1988560294","https://openalex.org/W1989226167","https://openalex.org/W1990828245","https://openalex.org/W2000728769","https://openalex.org/W2002447097","https://openalex.org/W2002573380","https://openalex.org/W2007754417","https://openalex.org/W2013556162","https://openalex.org/W2021800314","https://openalex.org/W2047840522","https://openalex.org/W2056361967","https://openalex.org/W2071675363","https://openalex.org/W2099642213","https://openalex.org/W2117947701","https://openalex.org/W2122232958","https://openalex.org/W2142373189","https://openalex.org/W2341969299"],"related_works":["https://openalex.org/W2143317827","https://openalex.org/W2432940338","https://openalex.org/W132272883","https://openalex.org/W2888856450","https://openalex.org/W1486357474","https://openalex.org/W240633180","https://openalex.org/W2070900226","https://openalex.org/W2057430323","https://openalex.org/W2023445821","https://openalex.org/W2010125625"],"abstract_inverted_index":{"A":[0],"panel":[1],"of":[2,16,51],"20":[3],"human":[4,62,125,127],"monoclonal":[5,30,111,116],"antibodies":[6,31,112],"was":[7],"produced":[8],"from":[9,12],"cells":[10],"derived":[11],"the":[13,66,81,98],"synovial":[14],"tissue":[15],"two":[17,47],"rheumatoid":[18,25,34],"arthritis":[19,26],"patients":[20],"and":[21,42,46,57,75,91,95,113,130],"one":[22,114],"polyarticular":[23],"juvenile":[24],"patient.":[27],"Fourteen":[28],"IgM":[29],"were":[32,53],"classical":[33],"factors":[35],"(RFs)":[36],"with":[37,59,72,88,97],"specificities":[38],"restricted":[39],"to":[40],"IgG":[41,56],"included":[43],"twelve":[44],"kappa":[45],"lambda":[48],"proteins.":[49,78,101],"Two":[50,79],"them":[52],"pan-specific":[54],"for":[55],"reacted":[58,71,87],"all":[60],"four":[61],"subclasses.":[63],"Nine":[64],"showed":[65,80],"Ga":[67],"specificity,":[68,84],"i.e.":[69,85],"they":[70,86],"IgG1,":[73,89],"IgG2":[74,90],"IgG4":[76,92],"subclass":[77,93],"'new":[82],"Ga-related'":[83],"proteins,":[94],"also":[96],"Ge3m(st)":[99],"allotype":[100],"One":[102],"RF":[103],"demonstrated":[104,118],"an":[105],"anti-G3m(u)":[106],"anti-allotypic":[107],"specificity.":[108],"Five":[109],"IgM(lambda)":[110],"IgM(kappa)":[115],"antibody":[117],"polyreactivity":[119],"against":[120],"various":[121],"antigens":[122],"including":[123],"DNA,":[124],"thyroglobulin,":[126],"serum":[128],"albumin":[129],"tetanus":[131],"toxoid.":[132]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}