{"id":"https://openalex.org/W2398577973","doi":null,"title":"Study of potential cytoprotective activity of different antioxidants.","display_name":"Study of potential cytoprotective activity of different antioxidants.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2398577973","mag":"2398577973","pmid":"https://pubmed.ncbi.nlm.nih.gov/20157213"},"language":"en","primary_location":{"id":"pmid:20157213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20157213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115598859","display_name":"Levani Ratiani","orcid":"https://orcid.org/0000-0002-2122-8915","observed_orcids":["https://orcid.org/0000-0002-2122-8915"]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"L Ratiani","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047768280","display_name":"T Ratiani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ratiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076546880","display_name":"G Sharashenidze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Sharashenidze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113360729","display_name":"Gvantsa Janigashvili","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Janigashvili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067857880","display_name":"Tamar V Sanikidze","orcid":"https://orcid.org/0000-0003-1618-5276","observed_orcids":["https://orcid.org/0000-0003-1618-5276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sanikidze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"178","first_page":"72","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8740000128746033},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9340000152587891},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8029999732971191},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.8579999804496765},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.9865394830703735},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8041015863418579},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7182151079177856},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5760210156440735},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4964028000831604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.493795245885849},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4527972638607025},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.4287394881248474},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41204673051834106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38820913434028625},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3831099271774292},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3411800265312195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34110307693481445},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3128671944141388},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.24731293320655823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20157213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20157213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"},{"id":"mag:2398577973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20157213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064787860","https://openalex.org/W1984486483","https://openalex.org/W3166555001","https://openalex.org/W81655644","https://openalex.org/W2989881233","https://openalex.org/W94719971","https://openalex.org/W1972975967","https://openalex.org/W1477550290","https://openalex.org/W2030359561","https://openalex.org/W7096591843"],"abstract_inverted_index":{"It":[0,93],"is":[1,59,152],"known":[2],"that":[3],"infiltration":[4],"of":[5,33,35,46,74,81,105,107,118,148,158,184,188,204],"atherosclerotic":[6],"plaques":[7],"by":[8,20,155],"activated":[9],"T":[10,52,69],"lymphocytes":[11,22],"occurs":[12],"at":[13],"the":[14,30,75,78,96,146,201],"early":[15],"stage":[16],"and":[17,44,64,102,136,150],"cytokines":[18],"produced":[19],"those":[21],"become":[23],"actively":[24],"involved":[25],"in":[26,62,89,111,163,193],"inflammatory":[27],"process.":[28],"Consequently":[29],"preparations,":[31],"capable":[32],"stabilization":[34],"immune":[36],"cells,":[37],"perhaps":[38],"will":[39],"be":[40],"effective":[41],"for":[42],"treatment":[43],"prevention":[45],"atherosclerosis.":[47],"Intensively":[48],"proliferated":[49],"Jurkat":[50,86,108,143,159,185,189],"leukemic":[51,56],"cell":[53,57],"line":[54],"(human":[55],"culture)":[58],"widely":[60],"used":[61],"scientific":[63],"Therapeutic":[65],"research,":[66],"as":[67],"human":[68],"lymphocyte":[70],"pattern.":[71],"The":[72],"aim":[73],"study--To":[76],"establish":[77],"cytoprotective":[79,202],"action":[80],"different":[82],"antioxidative":[83,174,205],"preparations":[84,175,206],"on":[85,141,182],"cells":[87,109,144,160,190],"incubated":[88,110],"oxidative":[90,113,165,195],"stress":[91,114,166,196],"conditions.":[92,115],"was":[94,207],"revealed":[95],"dose":[97],"(100":[98],"microl,":[99,123,170],"50":[100,171],"microl)":[101,125,172],"time-related":[103],"decrease":[104],"viability":[106,183],"high":[112],"Low":[116],"doses":[117],"hydrogen":[119],"peroxide":[120],"(H(2)O(2))":[121],"(25":[122],"11":[124],"present":[126],"cytotoxicity":[127],"only":[128],"within":[129],"short":[130],"terms":[131],"(8":[132],"hours).":[133],"Vitamins":[134],"C":[135],"E":[137],"have":[138],"cytotoxic":[139],"effects":[140],"intact":[142],"separately;":[145],"activity":[147,181,203],"Megavite":[149],"Phenovin":[151],"not":[153],"characterised":[154],"cytotoxicity.":[156],"Incubation":[157,187],"with":[161,191],"antioxidants":[162,192],"moderate":[164],"condition":[167,197],"(H(2)O(2)":[168,198],"25":[169],"all":[173],"(except":[176],"vitamin":[177],"C)":[178],"reveal":[179],"static":[180],"cells.":[186],"intensive":[194],"100":[199],"microl),":[200],"rather":[208],"low.":[209]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}