{"id":"https://openalex.org/W2398577929","doi":null,"title":"Examining mechanism of toxicity of copper oxide nanoparticles to Saccharomyces cerevisiae and Caenorhabditis elegans","display_name":"Examining mechanism of toxicity of copper oxide nanoparticles to Saccharomyces cerevisiae and Caenorhabditis elegans","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2398577929","mag":"2398577929"},"language":"en","primary_location":{"id":"pmh:oai:epublications.marquette.edu:dissertations_mu-1662","doi":null,"is_oa":true,"landing_page_url":"https://epublications.marquette.edu/dissertations_mu/609","pdf_url":"https://epublications.marquette.edu/dissertations_mu/609","source":{"id":"https://openalex.org/S4306401682","display_name":"e-Publications@Marquette (Marquette University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102461120","host_organization_name":"Marquette University","host_organization_lineage":["https://openalex.org/I102461120"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations (1934 -)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://epublications.marquette.edu/dissertations_mu/609","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015152059","display_name":"Michael J. Mashock","orcid":"https://orcid.org/0000-0003-0141-9770","observed_orcids":["https://orcid.org/0000-0003-0141-9770"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael J. Mashock","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0141-9770","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015152059"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.2919999957084656,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cuo-nanoparticles","display_name":"copper oxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9340000152587891},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":1.0},{"id":"https://openalex.org/keywords/copper-ion-release","display_name":"copper ion release","score":0.9290000200271606},{"id":"https://openalex.org/keywords/nanoparticle-dissolution","display_name":"nanoparticle dissolution","score":0.8650000095367432},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.656000018119812},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5059999823570251},{"id":"https://openalex.org/keywords/copper-sulfate","display_name":"copper sulfate","score":0.6259999871253967},{"id":"https://openalex.org/keywords/nematode-reproduction","display_name":"nematode reproduction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9670000076293945},{"id":"https://openalex.org/keywords/divalent-metal-transporter","display_name":"divalent metal transporter","score":0.7829999923706055},{"id":"https://openalex.org/keywords/nanoparticle-size-effects","display_name":"nanoparticle size effects","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8532639145851135},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6722984910011292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.511543869972229},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46817249059677124},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42987900972366333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3982604146003723},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37242943048477173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34319382905960083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32257264852523804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17479455471038818},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:epublications.marquette.edu:dissertations_mu-1662","doi":null,"is_oa":true,"landing_page_url":"https://epublications.marquette.edu/dissertations_mu/609","pdf_url":"https://epublications.marquette.edu/dissertations_mu/609","source":{"id":"https://openalex.org/S4306401682","display_name":"e-Publications@Marquette (Marquette University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102461120","host_organization_name":"Marquette University","host_organization_lineage":["https://openalex.org/I102461120"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations (1934 -)","raw_type":"text"},{"id":"mag:2398577929","doi":null,"is_oa":false,"landing_page_url":"https://epublications.marquette.edu/cgi/viewcontent.cgi?article=1662&context=dissertations_mu","pdf_url":null,"source":{"id":"https://openalex.org/S4306522422","display_name":"PhDT","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PhDT","raw_type":null}],"best_oa_location":{"id":"pmh:oai:epublications.marquette.edu:dissertations_mu-1662","doi":null,"is_oa":true,"landing_page_url":"https://epublications.marquette.edu/dissertations_mu/609","pdf_url":"https://epublications.marquette.edu/dissertations_mu/609","source":{"id":"https://openalex.org/S4306401682","display_name":"e-Publications@Marquette (Marquette University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102461120","host_organization_name":"Marquette University","host_organization_lineage":["https://openalex.org/I102461120"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations (1934 -)","raw_type":"text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2398577929.pdf","grobid_xml":"https://content.openalex.org/works/W2398577929.grobid-xml"},"referenced_works_count":187,"referenced_works":["https://openalex.org/W169880342","https://openalex.org/W1489110007","https://openalex.org/W1519464708","https://openalex.org/W1546952499","https://openalex.org/W1547975753","https://openalex.org/W1577577364","https://openalex.org/W1605585002","https://openalex.org/W1734082729","https://openalex.org/W1778463151","https://openalex.org/W1848489979","https://openalex.org/W1880600569","https://openalex.org/W1927962452","https://openalex.org/W1932435612","https://openalex.org/W1940267985","https://openalex.org/W1944127002","https://openalex.org/W1963648581","https://openalex.org/W1965037560","https://openalex.org/W1965770783","https://openalex.org/W1966307176","https://openalex.org/W1966476051","https://openalex.org/W1966521314","https://openalex.org/W1969205406","https://openalex.org/W1969806459","https://openalex.org/W1976451553","https://openalex.org/W1976544696","https://openalex.org/W1978562850","https://openalex.org/W1982364427","https://openalex.org/W1982494232","https://openalex.org/W1983814182","https://openalex.org/W1984164475","https://openalex.org/W1986288713","https://openalex.org/W1986661155","https://openalex.org/W1987154750","https://openalex.org/W1990323568","https://openalex.org/W1991039509","https://openalex.org/W1991042269","https://openalex.org/W1994619790","https://openalex.org/W1995628098","https://openalex.org/W1995999348","https://openalex.org/W1996896511","https://openalex.org/W1998224653","https://openalex.org/W2001629471","https://openalex.org/W2004595470","https://openalex.org/W2005229434","https://openalex.org/W2005843415","https://openalex.org/W2006161061","https://openalex.org/W2007476652","https://openalex.org/W2007792678","https://openalex.org/W2008934340","https://openalex.org/W2009570575","https://openalex.org/W2009728983","https://openalex.org/W2012648167","https://openalex.org/W2013319013","https://openalex.org/W2013773466","https://openalex.org/W2015513114","https://openalex.org/W2016009059","https://openalex.org/W2017398902","https://openalex.org/W2018836722","https://openalex.org/W2020479212","https://openalex.org/W2020582877","https://openalex.org/W2021373472","https://openalex.org/W2021664197","https://openalex.org/W2022228505","https://openalex.org/W2022585806","https://openalex.org/W2022818105","https://openalex.org/W2025102122","https://openalex.org/W2025144653","https://openalex.org/W2025423711","https://openalex.org/W2029437697","https://openalex.org/W2029589204","https://openalex.org/W2030045221","https://openalex.org/W2031305146","https://openalex.org/W2032495184","https://openalex.org/W2033657779","https://openalex.org/W2033803368","https://openalex.org/W2034685896","https://openalex.org/W2034742459","https://openalex.org/W2036896850","https://openalex.org/W2037756605","https://openalex.org/W2038142268","https://openalex.org/W2040708668","https://openalex.org/W2041105700","https://openalex.org/W2046011229","https://openalex.org/W2046639285","https://openalex.org/W2047806545","https://openalex.org/W2049136420","https://openalex.org/W2049151505","https://openalex.org/W2049883153","https://openalex.org/W2050353393","https://openalex.org/W2053310698","https://openalex.org/W2056901151","https://openalex.org/W2057617528","https://openalex.org/W2058274661","https://openalex.org/W2058831880","https://openalex.org/W2060827987","https://openalex.org/W2061662801","https://openalex.org/W2061817247","https://openalex.org/W2066456671","https://openalex.org/W2066621059","https://openalex.org/W2067018546","https://openalex.org/W2070765870","https://openalex.org/W2072252010","https://openalex.org/W2073414410","https://openalex.org/W2073454755","https://openalex.org/W2076142236","https://openalex.org/W2077349746","https://openalex.org/W2081298797","https://openalex.org/W2082501436","https://openalex.org/W2083170520","https://openalex.org/W2083404959","https://openalex.org/W2084038029","https://openalex.org/W2088152932","https://openalex.org/W2091739490","https://openalex.org/W2093792053","https://openalex.org/W2094374892","https://openalex.org/W2096837660","https://openalex.org/W2102218399","https://openalex.org/W2103017472","https://openalex.org/W2103502380","https://openalex.org/W2104086585","https://openalex.org/W2104402263","https://openalex.org/W2105982808","https://openalex.org/W2106662446","https://openalex.org/W2109515464","https://openalex.org/W2109755785","https://openalex.org/W2109756205","https://openalex.org/W2111379154","https://openalex.org/W2111479061","https://openalex.org/W2111845774","https://openalex.org/W2113131102","https://openalex.org/W2113906105","https://openalex.org/W2115891976","https://openalex.org/W2117326659","https://openalex.org/W2118236535","https://openalex.org/W2121352279","https://openalex.org/W2122575706","https://openalex.org/W2122749282","https://openalex.org/W2123019106","https://openalex.org/W2124610014","https://openalex.org/W2126194084","https://openalex.org/W2131752305","https://openalex.org/W2133465414","https://openalex.org/W2133505228","https://openalex.org/W2133976205","https://openalex.org/W2134363913","https://openalex.org/W2134488915","https://openalex.org/W2136351518","https://openalex.org/W2137260452","https://openalex.org/W2138397256","https://openalex.org/W2138456358","https://openalex.org/W2140561339","https://openalex.org/W2140665078","https://openalex.org/W2140720810","https://openalex.org/W2141562948","https://openalex.org/W2143466643","https://openalex.org/W2144291856","https://openalex.org/W2145355805","https://openalex.org/W2145606314","https://openalex.org/W2148427274","https://openalex.org/W2151811058","https://openalex.org/W2152058429","https://openalex.org/W2153652352","https://openalex.org/W2154952923","https://openalex.org/W2155000552","https://openalex.org/W2155118487","https://openalex.org/W2155557838","https://openalex.org/W2156780012","https://openalex.org/W2158217645","https://openalex.org/W2158320951","https://openalex.org/W2158558808","https://openalex.org/W2159325507","https://openalex.org/W2159482845","https://openalex.org/W2161733672","https://openalex.org/W2165246198","https://openalex.org/W2166574880","https://openalex.org/W2168974164","https://openalex.org/W2169547767","https://openalex.org/W2170701555","https://openalex.org/W2312607289","https://openalex.org/W2312982307","https://openalex.org/W2321375059","https://openalex.org/W2324506251","https://openalex.org/W2325211585","https://openalex.org/W2333156941","https://openalex.org/W2335280742","https://openalex.org/W2348589405","https://openalex.org/W2404755212"],"related_works":["https://openalex.org/W2522163786","https://openalex.org/W2557307285","https://openalex.org/W3049637780","https://openalex.org/W1859422174","https://openalex.org/W3096115980","https://openalex.org/W2344779372","https://openalex.org/W4414074420","https://openalex.org/W2183709661","https://openalex.org/W2979676872","https://openalex.org/W1572359063"],"abstract_inverted_index":{"Copper":[0],"oxide":[1,250,291,330],"nanoparticles":[2,251,341],"(CuO":[3],"NPs)":[4],"are":[5],"an":[6,151,163],"up":[7,283],"and":[8,16,19,26,47,71,100,138,178,242,252,306,342],"coming":[9],"technology":[10],"increasingly":[11],"being":[12],"used":[13],"in":[14,61,162,165,170,282,301],"industrial":[15],"consumer":[17],"applications":[18],"thus":[20],"may":[21,194,333],"pose":[22],"risk":[23],"to":[24,77,98,123,127,134,184,189,235,262,284,311,318,325,336,339],"humans":[25],"the":[27,30,33,72,78,93,106,246,287,302,319,340,346],"environment.":[28],"In":[29,266],"present":[31],"study,":[32],"toxic":[34],"effects":[35,247,324],"of":[36,52,58,85,213,248,286],"CuO":[37,59,124,136,214,227],"NPs":[38,60,94,125,137,185,215,228],"were":[39,64],"studied":[40,65],"with":[41,66,207,270],"two":[42],"model":[43],"organisms":[44,327],"Saccharomyces":[45],"cerevisiae":[46,87,111],"Caenorhabditis":[48],"elegans.":[49],"The":[50,131,211,226],"role":[51],"released":[53,73,107,139,208,347],"Cu":[54,80,108,140,209],"ions":[55,141],"during":[56],"dissolution":[57],"growth":[62],"media":[63],"freshly":[67],"suspended,":[68],"aged":[69],"NPs,":[70],"Cu2+":[74],"fraction.":[75],"Exposures":[76],"different":[79,202],"treatments":[81],"showed":[82,308],"significant":[83],"inhibition":[84],"S.":[86,110],"cellular":[88,132],"metabolic":[89,119],"activity.":[90],"Inhibition":[91],"from":[92,328,345],"was":[95,101,145,155,219,280],"inversely":[96],"proportional":[97],"size":[99],"not":[102,343],"fully":[103],"explained":[104],"by":[105,200,221],"ions.":[109,210,349],"cultures":[112,128],"grown":[113],"under":[114],"respiring":[115],"conditions":[116],"demonstrated":[117],"greater":[118],"sensitivity":[120],"when":[121],"exposed":[122,183],"compared":[126,234],"undergoing":[129],"fermentation.":[130],"response":[133],"both":[135,158],"on":[142,216,238,255],"gene":[143,299],"expression":[144],"analyzed":[146],"via":[147],"microarray":[148],"analysis":[149],"after":[150,289],"acute":[152],"exposure.":[153,293,313],"It":[154],"observed":[156,206,281],"that":[157,205,321],"copper":[159,236,249,253,290,312,329,348],"exposures":[160],"resulted":[161],"increase":[164],"carbohydrate":[166],"storage,":[167],"a":[168,201,230,258,273],"decrease":[169],"protein":[171,173,276],"production,":[172],"misfolding,":[174],"increased":[175,309],"membrane":[176],"permeability,":[177],"cell":[179,197],"cycle":[180,198],"arrest.":[181],"Cells":[182],"up-regulated":[186],"genes":[187],"related":[188],"oxidative":[190],"phosphorylation":[191],"but":[192],"also":[193],"be":[195,334],"inducing":[196],"arrest":[199],"mechanism":[203],"than":[204],"effect":[212],"C.":[217,268],"elegans":[218,269],"examined":[220],"using":[222],"several":[223],"toxicological":[224,323],"endpoints.":[225],"displayed":[229],"more":[231],"inhibitory":[232],"effect,":[233],"sulfate,":[237],"nematode":[239,295],"reproduction,":[240],"feeding,":[241],"development.":[243],"We":[244],"investigated":[245],"sulfate":[254],"neuronal":[256,278],"health,":[257],"known":[259],"tissue":[260],"vulnerable":[261],"heavy":[263],"metal":[264],"toxicity.":[265],"transgenic":[267],"neurons":[271],"expressing":[272],"green":[274],"fluorescent":[275],"reporter,":[277],"degeneration":[279],"10%":[285],"population":[288],"nanoparticle":[292,331],"Additionally,":[294],"mutant":[296],"strains":[297],"containing":[298],"knockouts":[300],"divalent-metal":[303],"transporters":[304],"smf-1":[305],"smf-2":[307],"tolerance":[310],"These":[314],"results":[315],"lend":[316],"credence":[317],"hypothesis":[320],"some":[322],"eukaryotic":[326],"exposure":[332],"due":[335],"properties":[337],"specific":[338],"solely":[344]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
