{"id":"https://openalex.org/W2398514982","doi":null,"title":"Modulation of natural killer activity in mice by prolonged administration of various doses of dietary retinoids.","display_name":"Modulation of natural killer activity in mice by prolonged administration of various doses of dietary retinoids.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2398514982","mag":"2398514982","pmid":"https://pubmed.ncbi.nlm.nih.gov/3785241"},"language":"en","primary_location":{"id":"pmid:3785241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3785241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural immunity and cell growth regulation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024871281","display_name":"Angela Santoni","orcid":"https://orcid.org/0000-0003-1206-7731","observed_orcids":["https://orcid.org/0000-0003-1206-7731"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Santoni","raw_affiliation_strings":["Istituto Neurologico Mediterraneo Neuromed"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Neurologico Mediterraneo Neuromed","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015433080","display_name":"S. Cerruti Sola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Cerruti Sola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090467586","display_name":"Mirella Giovarelli","orcid":"https://orcid.org/0000-0002-7397-3466","observed_orcids":["https://orcid.org/0000-0002-7397-3466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Giovarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016202359","display_name":"P Martinetto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Martinetto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071184657","display_name":"D. Vietti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Vietti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078075817","display_name":"G Forni","orcid":"https://orcid.org/0000-0002-4466-6029","observed_orcids":["https://orcid.org/0000-0002-4466-6029","https://orcid.org/0009-0005-3158-0348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Forni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"5","first_page":"259","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.04699999839067459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/retinyl-palmitate","display_name":"retinyl palmitate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/large-granular-lymphocytes","display_name":"large granular lymphocytes","score":0.781000018119812},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.6909999847412109},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6650000214576721},{"id":"https://openalex.org/keywords/spontaneous-cytotoxicity","display_name":"spontaneous cytotoxicity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/long-term-dietary-supplementation","display_name":"long-term dietary supplementation","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7482840418815613},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6938855051994324},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.6593010425567627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5718429684638977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5410200357437134},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.5287669897079468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4651188850402832},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44894692301750183},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4121629595756531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2503555715084076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18849939107894897},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07634341716766357}],"mesh":[{"descriptor_ui":"D000084562","descriptor_name":"Retinyl Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014801","descriptor_name":"Vitamin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:3785241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3785241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural immunity and cell growth regulation","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/390605","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/390605","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/32374","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/3785241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2398514982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3785241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001828293","https://openalex.org/W2265884298","https://openalex.org/W7018724158","https://openalex.org/W2042724060","https://openalex.org/W2412926325","https://openalex.org/W1982738648","https://openalex.org/W2023509788","https://openalex.org/W2001169784","https://openalex.org/W1977392240","https://openalex.org/W7076259"],"abstract_inverted_index":{"Groups":[0],"of":[1,8,54,84,94,106,119],"BALB/C":[2],"mice":[3,39],"received":[4],"a":[5,71,91],"diet":[6],"supplement":[7],"0":[9],"(group":[10,13,17,22],"C),":[11],"200":[12],"A":[14,18,23,64,66,69,102],"200),":[15],"500":[16,67],"500),":[19],"and":[20,50,68,87],"1,000":[21],"1,000)":[24],"IU":[25],"retinol":[26],"palmitate":[27],"(RP)/mouse/day":[28],"in":[29,59,74,97,126],"drinking":[30],"water":[31],"for":[32,45,51],"450":[33],"days.":[34],"At":[35],"progressive":[36],"time":[37],"intervals,":[38],"from":[40],"each":[41],"group":[42,101,128],"were":[43],"tested":[44],"natural":[46],"killer":[47],"(NK)":[48],"activity":[49,76],"the":[52,60,82,98,104],"percentage":[53],"large":[55],"granular":[56],"lymphocytes":[57],"(LGL)":[58],"spleen.":[61,99],"In":[62,100],"groups":[63],"200,":[65],"1,000,":[70,103],"dose-dependent":[72],"increase":[73,93,105],"NK":[75,122],"was":[77,88,124],"evident":[78],"50":[79],"days":[80],"after":[81],"beginning":[83],"RP":[85],"supplementation":[86],"accompanied":[89],"by":[90],"parallel":[92],"LGL":[95],"number":[96],"spontaneous":[107],"or":[108],"Poly":[109,120],"I:C-induced":[110,121],"cytotoxicity":[111,123],"persisted":[112],"until":[113],"day":[114,130],"160.":[115],"By":[116],"contrast,":[117],"inhibition":[118],"found":[125],"this":[127],"at":[129],"450.":[131]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}