{"id":"https://openalex.org/W2398503248","doi":null,"title":"Cost-effectiveness analysis of topical treatments for actinic keratosis in the perspective of the Italian health care system.","display_name":"Cost-effectiveness analysis of topical treatments for actinic keratosis in the perspective of the Italian health care system.","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W2398503248","mag":"2398503248","pmid":"https://pubmed.ncbi.nlm.nih.gov/20930692"},"language":"en","primary_location":{"id":"pmid:20930692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20930692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020186310","display_name":"Giorgio Lorenzo Colombo","orcid":"https://orcid.org/0000-0002-5790-8891","observed_orcids":["https://orcid.org/0000-0002-5790-8891"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G L Colombo","raw_affiliation_strings":["University of Pavia, Faculty of Pharmacy, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia, Faculty of Pharmacy, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065367798","display_name":"Sergio Chimenti","orcid":"https://orcid.org/0000-0003-3750-1792","observed_orcids":["https://orcid.org/0000-0003-3750-1792"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Chimenti","raw_affiliation_strings":["University of Rome Tor Vergata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rome Tor Vergata","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109248473","display_name":"S. Di Matteo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Di Matteo","raw_affiliation_strings":["SAVE - Studi Analisi Valutazioni Economiche"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAVE - Studi Analisi Valutazioni Economiche","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055362200","display_name":"Maria Concetta Fargnoli","orcid":"https://orcid.org/0000-0002-7249-2556","observed_orcids":["https://orcid.org/0000-0002-7249-2556"]},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M C Fargnoli","raw_affiliation_strings":["University of L'Aquila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of L'Aquila","institution_ids":["https://openalex.org/I26415053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071841724","display_name":"Pasquale Frascione","orcid":"https://orcid.org/0000-0002-5592-8485","observed_orcids":["https://orcid.org/0000-0002-5592-8485"]},"institutions":[{"id":"https://openalex.org/I4210141574","display_name":"San Gallicano Hospital","ror":"https://ror.org/03zhmy467","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210137471","https://openalex.org/I4210141574","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Frascione","raw_affiliation_strings":["Istituto S. Maria e S. Gallicano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto S. Maria e S. Gallicano","institution_ids":["https://openalex.org/I4210141574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080500839","display_name":"Vitaliano Silipo","orcid":"https://orcid.org/0000-0003-1631-5181","observed_orcids":["https://orcid.org/0000-0003-1631-5181"]},"institutions":[{"id":"https://openalex.org/I4210141574","display_name":"San Gallicano Hospital","ror":"https://ror.org/03zhmy467","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210137471","https://openalex.org/I4210141574","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Silipo","raw_affiliation_strings":["Istituto S. Maria e S. Gallicano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto S. Maria e S. Gallicano","institution_ids":["https://openalex.org/I4210141574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090628379","display_name":"Ketty Peris","orcid":"https://orcid.org/0000-0002-5237-0463","observed_orcids":["https://orcid.org/0000-0002-5237-0463","https://orcid.org/0000-0003-1957-6600"]},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"K Peris","raw_affiliation_strings":["University of L'Aquila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of L'Aquila","institution_ids":["https://openalex.org/I26415053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0982,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75346042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"145","issue":"5","first_page":"573","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinic-keratosis","display_name":"actinic keratosis","score":1.0},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.921999990940094},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hyaluronic-acid-hydrogel","display_name":"hyaluronic acid hydrogel","score":0.925000011920929},{"id":"https://openalex.org/keywords/imiquimod","display_name":"imiquimod","score":0.9760000109672546},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/methyl-aminolevulinate","display_name":"methyl aminolevulinate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma-prevention","display_name":"squamous cell carcinoma prevention","score":0.7889999747276306},{"id":"https://openalex.org/keywords/field-directed-therapy","display_name":"field-directed therapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/italian-national-health-service","display_name":"Italian National Health Service","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cost-per-responder","display_name":"cost per responder","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2777873816","wikidata":"https://www.wikidata.org/wiki/Q422225","display_name":"Actinic keratosis","level":3,"score":0.9462591409683228},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.9348165988922119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8363832831382751},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7344328165054321},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.6019077897071838},{"id":"https://openalex.org/C60120401","wikidata":"https://www.wikidata.org/wiki/Q17119253","display_name":"Field cancerization","level":3,"score":0.42540451884269714},{"id":"https://openalex.org/C2910086692","wikidata":"https://www.wikidata.org/wiki/Q422225","display_name":"Actinic keratoses","level":3,"score":0.420198529958725},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.4148203730583191},{"id":"https://openalex.org/C2778648961","wikidata":"https://www.wikidata.org/wiki/Q3667186","display_name":"Keratosis","level":2,"score":0.4129617214202881},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.38620492815971375},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32197946310043335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.201686829328537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1087670624256134},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077271","descriptor_name":"Imiquimod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003695","descriptor_name":"Delivery of Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055623","descriptor_name":"Keratosis, Actinic","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:20930692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20930692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia","raw_type":"Comparative Study"},{"id":"pmh:oai:ricerca.univaq.it:11697/12525","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11697/12525","pdf_url":null,"source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2398503248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20930692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1506822571","https://openalex.org/W1571761716","https://openalex.org/W1830855939","https://openalex.org/W1895525610","https://openalex.org/W1971174742","https://openalex.org/W1979452019","https://openalex.org/W1982581331","https://openalex.org/W1983907637","https://openalex.org/W1987137654","https://openalex.org/W1988722799","https://openalex.org/W1991949008","https://openalex.org/W2000475147","https://openalex.org/W2003383692","https://openalex.org/W2007413267","https://openalex.org/W2015147462","https://openalex.org/W2023374442","https://openalex.org/W2035816846","https://openalex.org/W2039832158","https://openalex.org/W2043900061","https://openalex.org/W2046979407","https://openalex.org/W2048051583","https://openalex.org/W2055979589","https://openalex.org/W2063652687","https://openalex.org/W2064019766","https://openalex.org/W2065482764","https://openalex.org/W2076544927","https://openalex.org/W2079827614","https://openalex.org/W2090512029","https://openalex.org/W2098885980","https://openalex.org/W2102528174","https://openalex.org/W2105808906","https://openalex.org/W2110269387","https://openalex.org/W2121049651","https://openalex.org/W2135110662","https://openalex.org/W2140611628","https://openalex.org/W2143844316","https://openalex.org/W2150469702","https://openalex.org/W2151481608","https://openalex.org/W2153509968","https://openalex.org/W2157545844","https://openalex.org/W2168408099","https://openalex.org/W2181899661","https://openalex.org/W2182393640","https://openalex.org/W2397894019","https://openalex.org/W2917583744","https://openalex.org/W4235781069"],"related_works":["https://openalex.org/W2169706019","https://openalex.org/W4403637467","https://openalex.org/W2792189835","https://openalex.org/W2039832158","https://openalex.org/W2903894092","https://openalex.org/W2594806444","https://openalex.org/W2542165545","https://openalex.org/W2368431576","https://openalex.org/W3000973067","https://openalex.org/W179846940"],"abstract_inverted_index":{"Actinic":[0],"keratosis":[1],"(AK)":[2],"is":[3,23],"the":[4,18,26,40,46,50,59,64,91,94,120,150,153,204,222],"most":[5,19],"common":[6],"cutaneous":[7],"malignant":[8],"neoplasm":[9],"and":[10,54,83,107,142,173,180,187,199,229],"its":[11],"prevalence":[12],"continues":[13],"to":[14,17,48,192],"increase.":[15],"According":[16],"recent":[20],"findings,":[21],"AK":[22,227],"currently":[24],"considered":[25,221],"initial":[27],"stage,":[28],"in":[29,74,90,162,185,190,217],"situ,":[30],"of":[31,66,93,127,194,206,224,236],"squamous":[32],"cell":[33],"carcinoma.":[34],"Field-directed":[35],"therapies":[36],"for":[37,69,182,226],"AKs":[38,70],"are":[39],"preferred":[41],"treatment":[42,223],"since":[43],"they":[44],"have":[45],"advantage":[47],"clear":[49],"clinically":[51,140],"visible":[52],"lesions":[53,57,139,228],"also":[55],"subclinical":[56],"within":[58],"cancerous":[60],"field.":[61],"We":[62,100],"assessed":[63],"cost-effectiveness":[65,213],"topical":[67],"treatments":[68],"including":[71],"3%":[72,161,184,216],"diclofenac":[73,183,215],"2.5%":[75],"hyaluronic":[76],"acid":[77],"(HA)":[78],"gel,":[79],"imiquimod":[80,174],"5%":[81],"cream":[82],"photodynamic":[84],"therapy":[85],"with":[86,137],"methyl":[87],"aminolevulinate":[88],"(MAL-PDT)":[89],"perspective":[92,122],"Italian":[95],"Health":[96],"Care":[97],"System":[98],"(SSN).":[99],"used":[101],"a":[102,124,135,233],"decision":[103],"tree":[104],"analytical":[105],"approach":[106],"efficacy":[108],"data":[109],"were":[110],"drawn":[111],"from":[112,119],"published":[113],"clinical":[114],"trials.":[115],"Cost":[116],"was":[117,132,158,164,178],"evaluated":[118],"SSN":[121],"during":[123],"time":[125],"horizon":[126],"3":[128],"months.":[129],"A":[130],"responder":[131,157],"defined":[133],"as":[134],"patient":[136],"all":[138],"cleared":[141],"showing":[143],"an":[144],"excellent":[145],"cosmetic":[146],"result.":[147],"Based":[148,210],"on":[149,211],"applied":[151],"model,":[152,214],"cost":[154],"per":[155],"complete":[156],"calculated.":[159],"Diclofenac":[160],"HA":[163,186,218],"less":[165],"expensive":[166],"(Euro":[167,171,175],"256)":[168],"than":[169],"MAL-PDT":[170,188],"320)":[172],"342).":[176],"Effectiveness":[177],"similar":[179],"better":[181],"(0.813%)":[189],"comparison":[191],"0.734%":[193],"imiquimod,":[195],"respectively.":[196],"The":[197],"one-way":[198],"probabilistic":[200],"sensitivity":[201],"analyses":[202],"confirmed":[203],"results":[205],"base":[207],"case":[208],"scenario.":[209],"this":[212],"can":[219],"be":[220],"choice":[225],"surrounding":[230],"field":[231],"under":[232],"pharmacoeconomic":[234],"point":[235],"view.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}