{"id":"https://openalex.org/W2398499033","doi":null,"title":"Genetic control of immunity to Trichinella spiralis infections of mice. Hypothesis to explain the role of H-2 genes in primary and challenge infections.","display_name":"Genetic control of immunity to Trichinella spiralis infections of mice. Hypothesis to explain the role of H-2 genes in primary and challenge infections.","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2398499033","mag":"2398499033","pmid":"https://pubmed.ncbi.nlm.nih.gov/6423524","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454539"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454539","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454539","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454539","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034877096","display_name":"Donald L. Wassom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Wassom","raw_affiliation_strings":["cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020889284","display_name":"D. Wakelin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Wakelin","raw_affiliation_strings":["cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109898535","display_name":"Barbara Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B O Brooks","raw_affiliation_strings":["cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027976630","display_name":"Christopher J. Krco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Krco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109087051","display_name":"Chella S. David","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S David","raw_affiliation_strings":["Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.5898,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.97603595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"51","issue":"4","first_page":"625","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichinella-spiralis","display_name":"Trichinella spiralis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/h-2-genes","display_name":"H-2 genes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.7379999756813049},{"id":"https://openalex.org/keywords/worm-expulsion","display_name":"worm expulsion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/challenge-infection","display_name":"challenge infection","score":0.8009999990463257},{"id":"https://openalex.org/keywords/primary-infection","display_name":"primary infection","score":0.8709999918937683},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.44200000166893005},{"id":"https://openalex.org/keywords/small-intestine-infection","display_name":"small intestine infection","score":0.37700000405311584},{"id":"https://openalex.org/keywords/neonate-larvae","display_name":"neonate larvae","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8537367582321167},{"id":"https://openalex.org/C2781320125","wikidata":"https://www.wikidata.org/wiki/Q730937","display_name":"Trichinella spiralis","level":3,"score":0.7004213333129883},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.5777801275253296},{"id":"https://openalex.org/C84951073","wikidata":"https://www.wikidata.org/wiki/Q2379153","display_name":"Congenic","level":3,"score":0.5394708514213562},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4856347143650055},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.4757106900215149},{"id":"https://openalex.org/C59659247","wikidata":"https://www.wikidata.org/wiki/Q11990","display_name":"Reproduction","level":2,"score":0.4521118700504303},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4500742256641388},{"id":"https://openalex.org/C2779726973","wikidata":"https://www.wikidata.org/wiki/Q578994","display_name":"Helminthiasis","level":2,"score":0.41430655121803284},{"id":"https://openalex.org/C169899063","wikidata":"https://www.wikidata.org/wiki/Q2842787","display_name":"Laboratory mouse","level":3,"score":0.4114946722984314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40039488673210144},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3311457335948944},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3210081458091736},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16335105895996094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15795490145683289},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10024502873420715},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014234","descriptor_name":"Trichinella","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014235","descriptor_name":"Trichinellosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014235","descriptor_name":"Trichinellosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014235","descriptor_name":"Trichinellosis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1454539","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454539","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:6423524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6423524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:2398499033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6423524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1454539","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1454539","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1523915052","https://openalex.org/W1974741673","https://openalex.org/W2003937731","https://openalex.org/W2014586841","https://openalex.org/W2030385109","https://openalex.org/W2056801818","https://openalex.org/W2070390623","https://openalex.org/W2085784674","https://openalex.org/W2089841641","https://openalex.org/W2417434637"],"related_works":["https://openalex.org/W2056801818","https://openalex.org/W2418208495","https://openalex.org/W1523915052","https://openalex.org/W2065238003","https://openalex.org/W2169283009","https://openalex.org/W2014586841","https://openalex.org/W2131722663","https://openalex.org/W2055946183","https://openalex.org/W2334089977","https://openalex.org/W2463254461"],"abstract_inverted_index":{"H-2":[0,308,397],"congenic":[1],"strains":[2,45,249,280],"of":[3,27,54,82,192,206,224,250,262,267,303,395],"mice":[4,32,58,79,87,106,117,130,154,203,220,251,256,292],"were":[5,118,155,176,198,293],"compared":[6,283],"for":[7,20,133,278],"their":[8,21,207,225],"ability":[9,22],"to":[10,23,110,284,359,370],"expel":[11,111],"T.":[12,194],"spiralis":[13,195],"infections":[14,39,185],"from":[15,56,75,113,128,146,152,160,174,182,290,298,322],"the":[16,25,44,114,210,255,260,263,316,323,326,344,361,373,376,380,392],"small":[17],"intestine":[18],"and":[19,37,47,64,85,131,172,228,232,259,325,340,379,389,398],"limit":[24],"reproduction":[26],"adult":[28],"female":[29,268],"worms.":[30],"B10.M":[31,57,105,147,153,175,202,219,299],"(H-2f)":[33],"expelled":[34,88,204,222,230],"both":[35,338,396],"primary":[36,51,285,339],"challenge":[38,274,341],"more":[40,90,178],"quickly":[41,109],"than":[42,71,92,143,158,180,296],"did":[43,97,144],"B10.Q(H-2q)":[46],"B10.BR(H-2k).":[48],"During":[49],"a":[50,189,239,273,356],"infection,":[52],"expulsion":[53,241,382],"worms":[55,89,112,126,145,159,173,181,208,269,289,297,321],"began":[59],"before":[60,168],"Day":[61,102,169,215],"9":[62,170],"post-infection":[63],"worm":[65,95,123,330],"counts":[66,76,96],"differed":[67],"significantly":[68,100,139],"(P":[69],"less":[70,156,294],".05":[72],"Student's":[73],"t-test)":[74],"in":[77,121,136,246,314,364],"B10.BR":[78,93,149,229],"on":[80,253],"each":[81],"Days":[83],"12":[84],"15.B10.Q":[86],"rapidly":[91],"but":[94,162],"not":[98,166],"differ":[99],"until":[101],"15.":[103],"Whereas":[104],"responded":[107],"most":[108,119],"gut,":[115],"B10.Q":[116,129,227,291],"effective":[120],"limiting":[122],"reproduction.":[124,331],"Female":[125],"harvested":[127],"cultured":[132],"24":[134,212],"hr":[135],"vitro":[137],"produced":[138],"fewer":[140],"newborn":[141],"larvae":[142,197],"or":[148,300],"mice.":[150],"Worms":[151],"fecund":[157,179,295],"B10.BR,":[161],"this":[163,371],"difference":[164],"was":[165,276],"apparent":[167],"post-infection,":[171],"always":[177],"B10.Q.":[183],"Challenge":[184],"21":[186],"days":[187,271],"following":[188,272],"priming":[190],"dose":[191],"200":[193],"muscle":[196],"rejected":[199],"very":[200],"quickly.":[201],"65%":[205],"during":[209,337],"first":[211],"h.":[213],"By":[214],"6":[216,270],"after":[217],"challenge,":[218],"had":[221],"84%":[223],"worms;":[226],"75%":[231],"37%":[233],"respectively.":[234],"These":[235,332],"results":[236,346,350],"suggest":[237],"that":[238,307],"rapid":[240,381],"response":[242,318,327,383],"may":[243],"be":[244],"expressed":[245,336],"many":[247],"different":[248],"depending":[252],"how":[254],"are":[257,335,384],"immunized":[258],"size":[261],"infecting":[264],"dose.":[265],"Fecundity":[266],"infection":[275,286],"reduced":[277],"all":[279],"tested":[281],"when":[282],"controls;":[287],"however,":[288],"B10.BR.":[301],"Results":[302],"these":[304],"experiments":[305],"demonstrate":[306],"genes":[309],"play":[310],"an":[311],"important":[312],"role":[313],"controlling":[315],"immune":[317],"which":[319,328],"expels":[320],"gut":[324],"limits":[329],"H-2-controlled":[333],"differences":[334],"infections.":[342],"As":[343],"present":[345],"conflict":[347],"somewhat":[348],"with":[349],"published":[351],"elsewhere,":[352],"we":[353],"have":[354],"proposed":[355],"new":[357],"hypothesis":[358],"explain":[360],"data":[362],"collected":[363],"our":[365],"laboratories":[366],"thus":[367],"far.":[368],"According":[369],"hypothesis,":[372],"anti-adult":[374],"response,":[375,378],"anti-fecundity":[377],"under":[385],"independent":[386],"genetic":[387],"control":[388],"influenced":[390],"by":[391],"interacting":[393],"products":[394],"non-H-2":[399],"genes.":[400]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
