{"id":"https://openalex.org/W2398054934","doi":"https://doi.org/10.1385/1-59259-084-5:99","title":"Mutation Detection in TGF-\u03b2 Receptors William M. Grady, Lois L. Myeroff, Hongmei He,","display_name":"Mutation Detection in TGF-\u03b2 Receptors William M. Grady, Lois L. Myeroff, Hongmei He,","publication_year":2003,"publication_date":"2003-11-14","ids":{"openalex":"https://openalex.org/W2398054934","doi":"https://doi.org/10.1385/1-59259-084-5:99","mag":"2398054934","pmid":"https://pubmed.ncbi.nlm.nih.gov/21318820"},"language":"en","primary_location":{"id":"doi:10.1385/1-59259-084-5:99","doi":"https://doi.org/10.1385/1-59259-084-5:99","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-084-5:99","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4245838993","display_name":"Colorectal Cancer"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052550785","display_name":"Sanford D. Markowitz","orcid":"https://orcid.org/0000-0001-5369-5254","observed_orcids":["https://orcid.org/0000-0001-5369-5254"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210119077","display_name":"University Hospitals Seidman Cancer Center","ror":"https://ror.org/02kb97560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sanford Markowitz","raw_affiliation_strings":["Ireland Cancer Center, University Hospitals of Cleveland, Cleveland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ireland Cancer Center, University Hospitals of Cleveland, Cleveland","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052550785"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210119077"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15689655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":null,"first_page":"99","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mutation-detection","display_name":"mutation detection","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tgf-beta-resistance","display_name":"TGF-beta resistance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8040000200271606},{"id":"https://openalex.org/keywords/smad-proteins","display_name":"Smad proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.8107165098190308},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.7517396211624146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7046803832054138},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6005695462226868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5471994280815125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4796719551086426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4384108781814575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42908990383148193},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4259829521179199},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30123400688171387}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59259-084-5:99","doi":"https://doi.org/10.1385/1-59259-084-5:99","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-084-5:99","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colorectal Cancer","raw_type":"book-chapter"},{"id":"pmid:21318820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21318820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1484024717","https://openalex.org/W1495031987","https://openalex.org/W1513040830","https://openalex.org/W1530163318","https://openalex.org/W1638980253","https://openalex.org/W1665402587","https://openalex.org/W1885022946","https://openalex.org/W1940496546","https://openalex.org/W2039828581","https://openalex.org/W2047044325","https://openalex.org/W2078214648","https://openalex.org/W2092513068","https://openalex.org/W2137393673","https://openalex.org/W2163432183"],"related_works":["https://openalex.org/W2424770255","https://openalex.org/W124804277","https://openalex.org/W2132790765","https://openalex.org/W2163859127","https://openalex.org/W7016464232","https://openalex.org/W7169909341","https://openalex.org/W2065317999","https://openalex.org/W648345218","https://openalex.org/W4205190446","https://openalex.org/W232933465"],"abstract_inverted_index":{"The":[0],"transforming":[1],"growth":[2,19,47],"factor":[3],"\u03b2":[4],"(TGF-\u03b2)":[5],"receptors":[6,75],"are":[7,34,43],"an":[8],"important":[9],"class":[10],"of":[11,20,29,50,55,57,80],"tumor":[12],"suppressor":[13],"gene.":[14],"TGF-\u03b2":[15,36,51,58,74,81],"markedly":[16],"inhibits":[17],"the":[18,46,73,77],"many":[21,30],"epithelial":[22],"cell":[23,41],"types;":[24],"whereas":[25],"in":[26,72],"contrast,":[27],"cancers":[28],"different":[31],"tissue":[32],"types":[33],"commonly":[35],"resistant":[37,44],"(10).":[38],"Many":[39],"cancer":[40],"lines":[42],"to":[45,67],"suppressive":[48],"effects":[49],"and":[52],"display":[53],"evidence":[54],"disruption":[56],"signal":[59],"transduction":[60],"(10,4,10).":[61],"To":[62],"date,":[63],"this":[64],"resistance":[65],"appears":[66],"often":[68],"result":[69],"from":[70],"mutations":[71],"or":[76],"smad":[78],"family":[79],"signaling":[82],"proteins":[83],"(5,11,12,14,16).":[84]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
