{"id":"https://openalex.org/W2398037874","doi":"https://doi.org/10.1080/02791072.2016.1188225","title":"Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans","display_name":"Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans","publication_year":2016,"publication_date":"2016-05-26","ids":{"openalex":"https://openalex.org/W2398037874","doi":"https://doi.org/10.1080/02791072.2016.1188225","mag":"2398037874","pmid":"https://pubmed.ncbi.nlm.nih.gov/27230395"},"language":"en","primary_location":{"id":"doi:10.1080/02791072.2016.1188225","doi":"https://doi.org/10.1080/02791072.2016.1188225","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02791072.2016.1188225","pdf_url":null,"source":{"id":"https://openalex.org/S149515109","display_name":"Journal of Psychoactive Drugs","issn_l":"0279-1072","issn":["0279-1072","2159-9777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychoactive Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/159021","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069258407","display_name":"Amanda Amorin Nunes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amanda A. Nunes","raw_affiliation_strings":["a Researcher, Institute of Biosciences, University Estadual Paulista \"J\u00falio de Mesquita Filho\" , Botucatu , Brazil","Researcher, Institute of Biosciences, University Estadual Paulista \"J\u00falio de Mesquita Filho\", Botucatu, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Researcher, Institute of Biosciences, University Estadual Paulista \"J\u00falio de Mesquita Filho\" , Botucatu , Brazil","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Researcher, Institute of Biosciences, University Estadual Paulista \"J\u00falio de Mesquita Filho\", Botucatu, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058075680","display_name":"RAFAEL GUIMAR\u00c3ES DOS SANTOS","orcid":"https://orcid.org/0000-0003-2388-4745","observed_orcids":["https://orcid.org/0000-0003-2388-4745"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405260535","display_name":"International Center for Ethnobotanical Education, Research, and Service","ror":"https://ror.org/03x4tmk23","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405260535"]}],"countries":["BR","ES"],"is_corresponding":true,"raw_author_name":"Rafael G. dos Santos","raw_affiliation_strings":["b Postdoctoral Fellow, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","c Advisory Board, International Center for Ethnobotanical Education, Research & Service , Amsterdam , The Netherlands","Advisory Board, International Center for Ethnobotanical Education, Research & Service, Amsterdam, The Netherlands","Postdoctoral Fellow, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Postdoctoral Fellow, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"c Advisory Board, International Center for Ethnobotanical Education, Research & Service , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4405260535"]},{"raw_affiliation_string":"Advisory Board, International Center for Ethnobotanical Education, Research & Service, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405260535"]},{"raw_affiliation_string":"Postdoctoral Fellow, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026333926","display_name":"Fl\u00e1via de Lima Os\u00f3rio","orcid":"https://orcid.org/0000-0003-1396-555X","observed_orcids":["https://orcid.org/0000-0003-1396-555X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4392738317","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia Translacional em Medicina","ror":"https://ror.org/01vt9w950","country_code":"BR","type":"facility","lineage":["https://openalex.org/I130442723","https://openalex.org/I4392738317"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via L. Os\u00f3rio","raw_affiliation_strings":["d Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","e Researcher, National Institute of Science and Technology-Translational Medicine , Ribeir\u00e3o Preto , Brazil","Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","Researcher, National Institute of Science and Technology\u2013Translational Medicine, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"d Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"e Researcher, National Institute of Science and Technology-Translational Medicine , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I4392738317"]},{"raw_affiliation_string":"Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Researcher, National Institute of Science and Technology\u2013Translational Medicine, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I4392738317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008318044","display_name":"Rafael Faria Sanches","orcid":"https://orcid.org/0000-0002-6746-8404","observed_orcids":["https://orcid.org/0000-0002-6746-8404"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael F. Sanches","raw_affiliation_strings":["f Psychiatrist, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","Psychiatrist, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"f Psychiatrist, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Psychiatrist, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054036019","display_name":"Jos\u00e9 Alexandre S. Crippa","orcid":"https://orcid.org/0000-0001-9520-6746","observed_orcids":["https://orcid.org/0000-0001-9520-6746"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4392738317","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia Translacional em Medicina","ror":"https://ror.org/01vt9w950","country_code":"BR","type":"facility","lineage":["https://openalex.org/I130442723","https://openalex.org/I4392738317"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Alexandre S. Crippa","raw_affiliation_strings":["g Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","h Researcher, National Institute of Science and Technology-Translational Medicine , Ribeir\u00e3o Preto , Brazil","Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","Researcher, National Institute of Science and Technology\u2013Translational Medicine, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"g Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"h Researcher, National Institute of Science and Technology-Translational Medicine , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I4392738317"]},{"raw_affiliation_string":"Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Researcher, National Institute of Science and Technology\u2013Translational Medicine, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I4392738317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102785969","display_name":"Jaime E. C. Hallak","orcid":"https://orcid.org/0000-0002-8784-0189","observed_orcids":["https://orcid.org/0000-0002-8784-0189","https://orcid.org/0000-0002-6452-0502"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4392738317","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia Translacional em Medicina","ror":"https://ror.org/01vt9w950","country_code":"BR","type":"facility","lineage":["https://openalex.org/I130442723","https://openalex.org/I4392738317"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jaime E. C. Hallak","raw_affiliation_strings":["g Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","h Researcher, National Institute of Science and Technology-Translational Medicine , Ribeir\u00e3o Preto , Brazil","Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","Researcher, National Institute of Science and Technology\u2013Translational Medicine, Ribeir\u00e3o Preto, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"g Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School , University of S\u00e3o Paulo , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"h Researcher, National Institute of Science and Technology-Translational Medicine , Ribeir\u00e3o Preto , Brazil","institution_ids":["https://openalex.org/I4392738317"]},{"raw_affiliation_string":"Professor, Department of Neurosciences and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Researcher, National Institute of Science and Technology\u2013Translational Medicine, Ribeir\u00e3o Preto, Brazil","institution_ids":["https://openalex.org/I4392738317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058075680"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405260535"],"apc_list":null,"apc_paid":null,"fwci":1.3904,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.78016086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"48","issue":"3","first_page":"195","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ayahuasca","display_name":"ayahuasca","score":1.0},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.765999972820282},{"id":"https://openalex.org/keywords/dimethyltryptamine","display_name":"dimethyltryptamine","score":0.8809999823570251},{"id":"https://openalex.org/keywords/beta-carbolines","display_name":"\u03b2-carbolines","score":0.8169999718666077},{"id":"https://openalex.org/keywords/harmaline","display_name":"harmaline","score":0.8519999980926514},{"id":"https://openalex.org/keywords/harmine","display_name":"harmine","score":1.0},{"id":"https://openalex.org/keywords/mao-a-inhibition","display_name":"MAO-A inhibition","score":0.8220000267028809},{"id":"https://openalex.org/keywords/5-ht2a-receptor-agonism","display_name":"5-HT2A receptor agonism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/substance-use-reduction","display_name":"substance use reduction","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hallucinogens","display_name":"hallucinogens","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2777066114","wikidata":"https://www.wikidata.org/wiki/Q380436","display_name":"Ayahuasca","level":2,"score":0.9960922002792358},{"id":"https://openalex.org/C2781450507","wikidata":"https://www.wikidata.org/wiki/Q128381","display_name":"Harmine","level":2,"score":0.9282165765762329},{"id":"https://openalex.org/C2780560928","wikidata":"https://www.wikidata.org/wiki/Q135270","display_name":"Harmaline","level":2,"score":0.8106716275215149},{"id":"https://openalex.org/C124315065","wikidata":"https://www.wikidata.org/wiki/Q194270","display_name":"Hallucinogen","level":2,"score":0.7352937459945679},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.7142782211303711},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.5074126124382019},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4934205114841461},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49129241704940796},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4845656454563141},{"id":"https://openalex.org/C2780237542","wikidata":"https://www.wikidata.org/wiki/Q94857","display_name":"Peganum harmala","level":2,"score":0.44688528776168823},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.42237505316734314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3331948518753052},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2932445704936981},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.26276296377182007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15212351083755493},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07140529155731201}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D031581","descriptor_name":"Banisteriopsis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031581","descriptor_name":"Banisteriopsis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031581","descriptor_name":"Banisteriopsis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031581","descriptor_name":"Banisteriopsis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/02791072.2016.1188225","doi":"https://doi.org/10.1080/02791072.2016.1188225","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02791072.2016.1188225","pdf_url":null,"source":{"id":"https://openalex.org/S149515109","display_name":"Journal of Psychoactive Drugs","issn_l":"0279-1072","issn":["0279-1072","2159-9777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychoactive Drugs","raw_type":"journal-article"},{"id":"pmid:27230395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27230395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychoactive drugs","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unesp.br:11449/159021","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/159021","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"pmh:oai:repositorio.unesp.br:11449/159021","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/159021","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/review"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W574241","https://openalex.org/W78622669","https://openalex.org/W161038337","https://openalex.org/W648645029","https://openalex.org/W1545232577","https://openalex.org/W1563242167","https://openalex.org/W1649318184","https://openalex.org/W1797327965","https://openalex.org/W1914275515","https://openalex.org/W1972616052","https://openalex.org/W1973324928","https://openalex.org/W1980721637","https://openalex.org/W1981281259","https://openalex.org/W1984596649","https://openalex.org/W1986425243","https://openalex.org/W1992914052","https://openalex.org/W1992997664","https://openalex.org/W2001101493","https://openalex.org/W2004537227","https://openalex.org/W2007872832","https://openalex.org/W2012159028","https://openalex.org/W2015676845","https://openalex.org/W2019379291","https://openalex.org/W2024880450","https://openalex.org/W2026668920","https://openalex.org/W2032058589","https://openalex.org/W2033818561","https://openalex.org/W2035391615","https://openalex.org/W2036881116","https://openalex.org/W2040244693","https://openalex.org/W2045887671","https://openalex.org/W2056609017","https://openalex.org/W2056628198","https://openalex.org/W2062339243","https://openalex.org/W2065718913","https://openalex.org/W2066488029","https://openalex.org/W2067177395","https://openalex.org/W2075238613","https://openalex.org/W2075703456","https://openalex.org/W2079365573","https://openalex.org/W2086022256","https://openalex.org/W2088493482","https://openalex.org/W2093477837","https://openalex.org/W2096058212","https://openalex.org/W2100834566","https://openalex.org/W2103583518","https://openalex.org/W2106410954","https://openalex.org/W2111920357","https://openalex.org/W2116852450","https://openalex.org/W2122459973","https://openalex.org/W2124026487","https://openalex.org/W2131640797","https://openalex.org/W2137983723","https://openalex.org/W2139192721","https://openalex.org/W2140013897","https://openalex.org/W2156098321","https://openalex.org/W2161617741","https://openalex.org/W2163858520","https://openalex.org/W2300458685","https://openalex.org/W2419844652","https://openalex.org/W2486356005","https://openalex.org/W2597417601","https://openalex.org/W4235058591","https://openalex.org/W4253768790","https://openalex.org/W4255232989"],"related_works":["https://openalex.org/W3158614341","https://openalex.org/W4415719438","https://openalex.org/W2019379291","https://openalex.org/W3094461574","https://openalex.org/W4400475657","https://openalex.org/W7167347191","https://openalex.org/W6998941790","https://openalex.org/W2101808966","https://openalex.org/W4404546069","https://openalex.org/W2118033121"],"abstract_inverted_index":{"Recently,":[0],"the":[1,18,43,55,100,125,143,159],"anti-addictive":[2,126],"potential":[3],"of":[4,17,57,81,90,108,128,148,161],"ayahuasca,":[5],"a":[6,38],"dimethyltryptamine(DMT)-":[7],"and":[8,21,77,130,145,163],"\u03b2-carboline-rich":[9],"hallucinogenic":[10],"beverage":[11],"traditionally":[12],"used":[13],"by":[14,23,142],"indigenous":[15],"groups":[16],"Northwest":[19],"Amazon":[20],"currently":[22],"syncretic":[24],"churches":[25],"worldwide,":[26],"has":[27],"received":[28],"increased":[29],"attention.":[30],"To":[31],"better":[32],"evaluate":[33],"this":[34],"topic,":[35],"we":[36],"performed":[37],"systematic":[39],"literature":[40],"review":[41],"using":[42],"PubMed":[44],"database":[45],"to":[46,96,158,173],"find":[47],"quantitative":[48],"studies":[49,71,80,87,170],"(using":[50,72],"statistical":[51],"analysis)":[52],"that":[53],"assessed":[54],"effects":[56],"ayahuasca":[58,83,129],"or":[59,65,75,92,111],"its":[60,131],"components":[61],"in":[62,154],"drug-related":[63],"symptoms":[64,110],"disorders.":[66,98],"We":[67],"found":[68],"five":[69,78,101],"animal":[70,86],"harmaline,":[73],"harmine,":[74],"ayahuasca)":[76],"observational":[79],"regular":[82],"consumers.":[84],"All":[85],"showed":[88],"improvement":[89],"biochemical":[91],"behavioral":[93],"parameters":[94],"related":[95,157],"drug-induced":[97],"Of":[99],"human":[102],"studies,":[103],"four":[104],"reported":[105],"significant":[106,119],"reductions":[107],"dependence":[109],"substance":[112],"use,":[113],"while":[114],"one":[115],"did":[116],"not":[117,134],"report":[118],"results.":[120],"The":[121],"mechanisms":[122],"responsible":[123],"for":[124],"properties":[127],"alkaloids":[132],"are":[133,167,171],"clarified,":[135],"apparently":[136],"involving":[137],"both":[138],"peripheral":[139],"MAO-A":[140],"inhibition":[141],"\u03b2-carbolines":[144],"central":[146],"agonism":[147],"DMT":[149],"at":[150],"5-HT2A":[151],"receptors":[152],"expressed":[153],"brain":[155],"regions":[156],"regulation":[160],"mood":[162],"emotions.":[164],"Although":[165],"results":[166],"promising,":[168],"controlled":[169],"needed":[172],"replicate":[174],"these":[175],"preliminary":[176],"findings.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}