{"id":"https://openalex.org/W2398029899","doi":"https://doi.org/10.2119/molmed.2015.00183","title":"Biomarkers for Bone Tumors: Discovery from Genomics and Proteomics Studies and Their Challenges","display_name":"Biomarkers for Bone Tumors: Discovery from Genomics and Proteomics Studies and Their Challenges","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2398029899","doi":"https://doi.org/10.2119/molmed.2015.00183","mag":"2398029899","pmid":"https://pubmed.ncbi.nlm.nih.gov/26581086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4818258"},"language":"en","primary_location":{"id":"doi:10.2119/molmed.2015.00183","doi":"https://doi.org/10.2119/molmed.2015.00183","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2015.00183","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00183","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039996349","display_name":"Wan Izlina Wan\u2010Ibrahim","orcid":"https://orcid.org/0000-0002-9227-541X","observed_orcids":["https://orcid.org/0000-0002-9227-541X"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Wan I. Wan-Ibrahim","raw_affiliation_strings":["Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]},{"raw_affiliation_string":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040877079","display_name":"Vivek Ajit Singh","orcid":"https://orcid.org/0000-0001-8899-9266","observed_orcids":["https://orcid.org/0000-0001-8899-9266"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Vivek A. Singh","raw_affiliation_strings":["Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042607109","display_name":"Onn Haji Hashim","orcid":"https://orcid.org/0000-0002-0196-6793","observed_orcids":["https://orcid.org/0000-0002-0196-6793"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Onn H. Hashim","raw_affiliation_strings":["Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","University of Malaya Centre of Proteomics Research (UMCPR), University of Malaya, Kuala Lumpur, Malaysia","Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]},{"raw_affiliation_string":"University of Malaya Centre of Proteomics Research (UMCPR), University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]},{"raw_affiliation_string":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010983166","display_name":"Puteri Shafinaz Abdul\u2010Rahman","orcid":"https://orcid.org/0000-0002-1818-4552","observed_orcids":["https://orcid.org/0000-0002-1818-4552"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Puteri S. Abdul-Rahman","raw_affiliation_strings":["Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","University of Malaya Centre of Proteomics Research (UMCPR), University of Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]},{"raw_affiliation_string":"University of Malaya Centre of Proteomics Research (UMCPR), University of Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010983166"],"corresponding_institution_ids":["https://openalex.org/I33849332"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.0481,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.7911134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"861","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-tumors","display_name":"bone tumors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8240000009536743},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":1.0},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/giant-cell-tumor-of-bone","display_name":"giant cell tumor of bone","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-biomarkers","display_name":"DNA biomarkers","score":0.9179999828338623},{"id":"https://openalex.org/keywords/protein-biomarkers","display_name":"protein biomarkers","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.9449999928474426},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9419999718666077},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.6209999918937683},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.7207125425338745},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6859488487243652},{"id":"https://openalex.org/C2776302905","wikidata":"https://www.wikidata.org/wiki/Q1076087","display_name":"Chondrosarcoma","level":2,"score":0.6315585374832153},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.5936559438705444},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4830794632434845},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4766284227371216},{"id":"https://openalex.org/C2909636867","wikidata":"https://www.wikidata.org/wiki/Q56014469","display_name":"Bone Sarcoma","level":3,"score":0.43960708379745483},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.43416279554367065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4337322413921356},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4259708523750305},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4047199785709381},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3899906873703003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3510296940803528},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.10576292872428894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09687498211860657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2119/molmed.2015.00183","doi":"https://doi.org/10.2119/molmed.2015.00183","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2015.00183","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00183","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3794898","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4818258","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4818258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4818258","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med","raw_type":"Text"},{"id":"pmid:26581086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26581086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine (Cambridge, Mass.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2119/molmed.2015.00183","doi":"https://doi.org/10.2119/molmed.2015.00183","is_oa":true,"landing_page_url":"https://doi.org/10.2119/molmed.2015.00183","pdf_url":"https://molmed.biomedcentral.com/counter/pdf/10.2119/molmed.2015.00183","source":{"id":"https://openalex.org/S6769275","display_name":"Molecular Medicine","issn_l":"1076-1551","issn":["1076-1551","1528-3658"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321709","display_name":"Ministry of Higher Education, Malaysia","ror":"https://ror.org/05mcs2t73"},{"id":"https://openalex.org/F4320322604","display_name":"Universiti Malaya","ror":"https://ror.org/00rzspn62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2398029899.pdf","grobid_xml":"https://content.openalex.org/works/W2398029899.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W56550348","https://openalex.org/W64437655","https://openalex.org/W81826961","https://openalex.org/W89333707","https://openalex.org/W91108901","https://openalex.org/W224193107","https://openalex.org/W246460242","https://openalex.org/W1490345952","https://openalex.org/W1536912963","https://openalex.org/W1830380976","https://openalex.org/W1840387029","https://openalex.org/W1939500389","https://openalex.org/W1956778815","https://openalex.org/W1965044145","https://openalex.org/W1966580149","https://openalex.org/W1967567894","https://openalex.org/W1968813633","https://openalex.org/W1969374083","https://openalex.org/W1970736783","https://openalex.org/W1974500649","https://openalex.org/W1975954160","https://openalex.org/W1976426421","https://openalex.org/W1979275715","https://openalex.org/W1980620749","https://openalex.org/W1989717042","https://openalex.org/W1990164134","https://openalex.org/W1998252246","https://openalex.org/W2000671339","https://openalex.org/W2001824461","https://openalex.org/W2003320275","https://openalex.org/W2005441809","https://openalex.org/W2007276563","https://openalex.org/W2010520132","https://openalex.org/W2012567585","https://openalex.org/W2014578307","https://openalex.org/W2015184241","https://openalex.org/W2016987712","https://openalex.org/W2017777108","https://openalex.org/W2019259784","https://openalex.org/W2025988600","https://openalex.org/W2027600681","https://openalex.org/W2030204681","https://openalex.org/W2031193398","https://openalex.org/W2035484548","https://openalex.org/W2036641811","https://openalex.org/W2036763367","https://openalex.org/W2038228386","https://openalex.org/W2039461477","https://openalex.org/W2040804632","https://openalex.org/W2040958716","https://openalex.org/W2041489973","https://openalex.org/W2042990492","https://openalex.org/W2046597088","https://openalex.org/W2046835431","https://openalex.org/W2047415315","https://openalex.org/W2047512035","https://openalex.org/W2051830951","https://openalex.org/W2054468933","https://openalex.org/W2056467018","https://openalex.org/W2057977080","https://openalex.org/W2058670939","https://openalex.org/W2063243157","https://openalex.org/W2064451247","https://openalex.org/W2083463213","https://openalex.org/W2084183058","https://openalex.org/W2085578084","https://openalex.org/W2097180978","https://openalex.org/W2099794827","https://openalex.org/W2104786760","https://openalex.org/W2105017286","https://openalex.org/W2106482095","https://openalex.org/W2107710616","https://openalex.org/W2109740762","https://openalex.org/W2112996488","https://openalex.org/W2113432838","https://openalex.org/W2116577297","https://openalex.org/W2116790797","https://openalex.org/W2117098825","https://openalex.org/W2118536741","https://openalex.org/W2119516652","https://openalex.org/W2119820677","https://openalex.org/W2120016245","https://openalex.org/W2121032725","https://openalex.org/W2123324173","https://openalex.org/W2125915621","https://openalex.org/W2126415088","https://openalex.org/W2127532437","https://openalex.org/W2128347832","https://openalex.org/W2128432283","https://openalex.org/W2128952020","https://openalex.org/W2131885284","https://openalex.org/W2132592568","https://openalex.org/W2132727601","https://openalex.org/W2134389439","https://openalex.org/W2135814599","https://openalex.org/W2137723853","https://openalex.org/W2138122497","https://openalex.org/W2142360616","https://openalex.org/W2142846876","https://openalex.org/W2144979640","https://openalex.org/W2148373690","https://openalex.org/W2149146896","https://openalex.org/W2152180036","https://openalex.org/W2154162926","https://openalex.org/W2156216776","https://openalex.org/W2157377088","https://openalex.org/W2159851092","https://openalex.org/W2161371306","https://openalex.org/W2161595887","https://openalex.org/W2162217976","https://openalex.org/W2166549384","https://openalex.org/W2168472158","https://openalex.org/W2170556067","https://openalex.org/W2416388556","https://openalex.org/W2418215364","https://openalex.org/W2484241932","https://openalex.org/W2512906422","https://openalex.org/W4292542148","https://openalex.org/W4302069788"],"related_works":["https://openalex.org/W4410969883","https://openalex.org/W4395076413","https://openalex.org/W2605307592","https://openalex.org/W2004450746","https://openalex.org/W3154965842","https://openalex.org/W3204033312","https://openalex.org/W2546256677","https://openalex.org/W7098618706","https://openalex.org/W2501557423","https://openalex.org/W2611143369"],"abstract_inverted_index":{"Diagnosis":[0],"of":[1,43,65,90],"bone":[2,44,66],"tumor":[3,78],"currently":[4],"relies":[5],"on":[6],"imaging":[7],"and":[8,10,30,51,75,88,113],"biopsy,":[9],"hence,":[11],"the":[12,57,61,84,96,101,109,114,120,123],"need":[13],"to":[14,122],"find":[15],"less":[16],"invasive":[17],"ways":[18],"for":[19,40,60],"its":[20],"accurate":[21],"detection.":[22],"More":[23],"recently,":[24],"numerous":[25],"promising":[26],"deoxyribonucleic":[27],"acid":[28],"(DNA)":[29],"protein":[31],"biomarkers":[32,59],"with":[33],"significant":[34],"prognostic,":[35],"diagnostic":[36],"and/or":[37],"predictive":[38],"abilities":[39],"various":[41],"types":[42,64],"tumors":[45,67],"have":[46],"been":[47],"identified":[48],"from":[49,83,119],"genomics":[50],"proteomics":[52],"studies.":[53,85],"This":[54],"article":[55],"reviewed":[56],"putative":[58],"more":[62],"common":[63],"(that":[68],"is,":[69],"osteosarcoma,":[70],"Ewing":[71],"sarcoma,":[72],"chondrosarcoma":[73],"[malignant]":[74],"giant":[76],"cell":[77],"[benign])":[79],"that":[80],"were":[81,103,126],"unveiled":[82],"The":[86],"benefits":[87],"drawbacks":[89],"these":[91],"biomarkers,":[92],"as":[93,95],"well":[94],"technology":[97],"platforms":[98],"involved":[99],"in":[100,108,116],"research,":[102],"also":[104,127],"discussed.":[105],"Challenges":[106],"faced":[107],"biomarker":[110],"discovery":[111],"studies":[112],"problems":[115],"their":[117],"translation":[118],"bench":[121],"clinical":[124],"settings":[125],"addressed.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}