{"id":"https://openalex.org/W2397982554","doi":null,"title":"Local control after the use of adjuvant electron beam intraoperative radiotherapy in patients with high-risk head and neck cancer: the UCSF experience.","display_name":"Local control after the use of adjuvant electron beam intraoperative radiotherapy in patients with high-risk head and neck cancer: the UCSF experience.","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2397982554","mag":"2397982554","pmid":"https://pubmed.ncbi.nlm.nih.gov/9166552"},"language":"en","primary_location":{"id":"pmid:9166552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9166552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The cancer journal from Scientific American","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031349941","display_name":"Ling Sm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Ling","raw_affiliation_strings":["Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051570421","display_name":"Michael Charles Roach","orcid":"https://orcid.org/0000-0001-6954-3730","observed_orcids":["https://orcid.org/0000-0001-6954-3730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Roach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038664078","display_name":"Fu Kk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K K Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074660288","display_name":"C Coleman","orcid":"https://orcid.org/0009-0006-6836-9607","observed_orcids":["https://orcid.org/0009-0006-6836-9607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Coleman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038300814","display_name":"Mark I. Singer","orcid":"https://orcid.org/0000-0002-0309-7405","observed_orcids":["https://orcid.org/0000-0002-0309-7405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Singer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0543,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.80725484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"6","first_page":"321","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/local-regional-control","display_name":"local-regional control","score":0.8230000138282776},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8880000114440918},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/recurrent-head-and-neck-cancer","display_name":"recurrent head and neck cancer","score":0.8109999895095825},{"id":"https://openalex.org/keywords/high-risk-factors","display_name":"high-risk factors","score":0.5479999780654907},{"id":"https://openalex.org/keywords/treatment-related-complications","display_name":"treatment complications","score":0.5379999876022339},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8190000057220459},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.3619999885559082},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.6930000185966492},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.38100001215934753},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9504603743553162},{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.5958113670349121},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5929467678070068},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5617973804473877},{"id":"https://openalex.org/C2775908122","wikidata":"https://www.wikidata.org/wiki/Q3070621","display_name":"External beam radiotherapy","level":4,"score":0.5221177339553833},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4920489490032196},{"id":"https://openalex.org/C2779494622","wikidata":"https://www.wikidata.org/wiki/Q3928881","display_name":"Intraoperative radiation therapy","level":3,"score":0.44771188497543335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43250572681427},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.4252094030380249},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.380234956741333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11153703927993774}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007432","descriptor_name":"Intraoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011882","descriptor_name":"Radiotherapy, High-Energy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9166552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9166552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The cancer journal from Scientific American","raw_type":"Journal Article"},{"id":"mag:2397982554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9166552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097325383","https://openalex.org/W2915728314","https://openalex.org/W2098340455","https://openalex.org/W2317198039","https://openalex.org/W1988308315","https://openalex.org/W4293074203","https://openalex.org/W1997709998","https://openalex.org/W2095003686","https://openalex.org/W2060393398","https://openalex.org/W2004473443"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"assess":[2],"the":[3,82,98,101,171,196,228,235,364,369],"effect":[4],"of":[5,34,100,167,211,271,276,293,366,371],"electron":[6],"beam":[7,340],"intraoperative":[8],"radiotherapy":[9,72,341],"(EB-IORT)":[10],"on":[11],"local-regional":[12,197,310],"control":[13,198,311],"and":[14,26,39,106,201,231,245,253,342,376],"any":[15],"associated":[16],"complications":[17,202,302],"in":[18,58,138,189,326,330,368],"patients":[19,36,60,112,215,239,257,263,296,331],"with":[20,37,69,88,174,260,332],"locally":[21],"advanced":[22,103,372],"or":[23,63,75,108,119,134,176,373],"recurrent":[24,62,374],"head":[25,38,375],"neck":[27,40,377],"cancer.":[28,378],"MATERIALS":[29],"AND":[30],"METHODS:":[31],"The":[32,54,141,152,307],"records":[33],"30":[35,212],"cancer":[41],"who":[42],"received":[43],"EB-IORT":[44,57,160,229,236,320,345,367],"from":[45,184],"March":[46],"1991":[47],"to":[48,123,147,170,186,194,266,282,305,361],"December":[49],"1994":[50],"were":[51,61,144,192,233],"retrospectively":[52],"reviewed.":[53],"indications":[55],"for":[56,92,150],"25":[59],"persistent":[64],"disease":[65,87],"despite":[66],"previous":[67,337],"treatment":[68],"full-course":[70,338],"external-beam":[71],"and/or":[73],"one":[74,224,246],"more":[76],"resections.":[77],"In":[78],"five":[79,259],"other":[80],"cases":[81],"indication":[83],"was":[84,127,156,161,226,280,291,313],"extensive":[85,104,343],"primary":[86],"multiple":[89,333],"high-risk":[90,334],"factors":[91],"local":[93,219,251,328],"recurrence,":[94],"including":[95],"extension":[96],"into":[97],"base":[99],"skull,":[102],"disease,":[105],"perineural":[107],"bony":[109],"invasion.":[110],"All":[111],"had":[113,217,249,299],"a":[114,164,207],"Karnofsky":[115],"performance":[116],"score":[117],">":[118],"=":[120],"70":[121],"prior":[122],"EB-IORT.":[124,204,306],"Median":[125],"age":[126],"65":[128],"years.":[129],"Final":[130],"pathology":[131],"revealed":[132],"positive":[133],"close":[135],"surgical":[136],"margins":[137],"all":[139],"patients.":[140],"areas":[142],"treated":[143],"generally":[145],"inaccessible":[146],"catheter":[148],"placement":[149],"brachytherapy.":[151],"most":[153],"common":[154],"histology":[155],"squamous":[157],"cell":[158],"carcinoma.":[159],"given":[162],"as":[163],"single":[165],"fraction":[166],"1500":[168],"cGy":[169],"90%":[172],"isodose":[173],"6":[175],"9":[177],"Mev":[178],"electrons":[179],"using":[180],"cone":[181],"sizes":[182],"ranging":[183],"2.5":[185],"7":[187],"cm":[188],"diameter.":[190],"Data":[191],"analyzed":[193],"determine":[195],"rate,":[199],"survival,":[200],"after":[203,284],"RESULTS:":[205],"With":[206],"median":[208],"follow-up":[209,283],"time":[210],"months,":[213],"nine":[214],"(27%)":[216],"only":[218,223,244],"recurrence.":[220],"Of":[221],"these,":[222],"recurrence":[225,252,329],"inside":[227],"field":[230],"eight":[232],"outside":[234],"field.":[237],"Two":[238],"(7%)":[240],"developed":[241],"distant":[242,254],"metastases":[243],"patient":[247,279],"(3%)":[248],"both":[250],"metastasis.":[255],"Seven":[256],"died,":[258],"disease.":[261,277,294],"Twenty-two":[262],"are":[264,355,359],"known":[265],"be":[267],"alive,":[268],"15":[269],"(68%)":[270],"whom":[272],"have":[273,298],"no":[274],"evidence":[275],"One":[278],"lost":[281],"12":[285],"months;":[286],"when":[287],"last":[288],"examined":[289],"he":[290],"free":[292],"Five":[295],"(16%)":[297],"mild-to-moderate":[300],"transient":[301],"probably":[303],"related":[304],"3-year":[308],"actuarial":[309],"rate":[312],"60%.":[314],"CONCLUSIONS:":[315],"Our":[316],"data":[317],"suggest":[318],"that":[319],"may":[321],"play":[322],"an":[323],"important":[324],"role":[325,365],"decreasing":[327],"factors.":[335],"Despite":[336],"external":[339],"resections,":[344],"did":[346],"not":[347],"confer":[348],"significant":[349],"additional":[350],"long-term":[351],"morbidity.":[352],"Although":[353],"results":[354],"encouraging,":[356],"randomized":[357],"studies":[358],"required":[360],"definitively":[362],"establish":[363],"management":[370]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}