{"id":"https://openalex.org/W2397968828","doi":null,"title":"Age-linked alterations in fructose-2,6-bisphosphate-induced modulation of rat muscle phosphofructokinase.","display_name":"Age-linked alterations in fructose-2,6-bisphosphate-induced modulation of rat muscle phosphofructokinase.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2397968828","mag":"2397968828","pmid":"https://pubmed.ncbi.nlm.nih.gov/2534568"},"language":"en","primary_location":{"id":"pmid:2534568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2534568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry international","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039478395","display_name":"Trigun Sk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S K Trigun","raw_affiliation_strings":["Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India","Biochemistry & Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]},{"raw_affiliation_string":"Biochemistry & Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India","institution_ids":["https://openalex.org/I91357014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104358475","display_name":"Singh Sn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.15552528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"6","first_page":"1213","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphofructokinase","display_name":"phosphofructokinase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fructose-2-6-bisphosphate","display_name":"fructose-2,6-bisphosphate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/age-related-enzyme-changes","display_name":"age-related enzyme changes","score":0.6100000143051147},{"id":"https://openalex.org/keywords/citrate-inhibition","display_name":"citrate inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/glucose-1-6-bisphosphate","display_name":"glucose 1,6-bisphosphate","score":0.9409999847412109},{"id":"https://openalex.org/keywords/amp-activation","display_name":"AMP activation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/atp-inhibition","display_name":"ATP inhibition","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.9210000038146973},{"id":"https://openalex.org/keywords/enzyme-conformational-change","display_name":"enzyme conformational change","score":0.8259999752044678},{"id":"https://openalex.org/keywords/rat-skeletal-muscle","display_name":"rat skeletal muscle","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C122245378","wikidata":"https://www.wikidata.org/wiki/Q14771739","display_name":"Phosphofructokinase","level":4,"score":0.94850754737854},{"id":"https://openalex.org/C2777284241","wikidata":"https://www.wikidata.org/wiki/Q417484","display_name":"Fructose 2,6-bisphosphate","level":5,"score":0.853797435760498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6973452568054199},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.6867234706878662},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6822558641433716},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6679388284683228},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.65293288230896},{"id":"https://openalex.org/C189909181","wikidata":"https://www.wikidata.org/wiki/Q899507","display_name":"Fructose 1,6-bisphosphatase","level":3,"score":0.6018773913383484},{"id":"https://openalex.org/C58431802","wikidata":"https://www.wikidata.org/wiki/Q420663","display_name":"Phosphofructokinase 2","level":3,"score":0.593866229057312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5485896468162537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3792600631713867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32445526123046875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2136521339416504}],"mesh":[{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005635","descriptor_name":"Fructosediphosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006598","descriptor_name":"Hexosediphosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010732","descriptor_name":"Phosphofructokinase-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010732","descriptor_name":"Phosphofructokinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011732","descriptor_name":"Pyridoxal Phosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2534568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2534568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry international","raw_type":"Journal Article"},{"id":"mag:2397968828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2534568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087821771","https://openalex.org/W2466895106","https://openalex.org/W2023797874","https://openalex.org/W1497976286","https://openalex.org/W2468918292","https://openalex.org/W2017085430","https://openalex.org/W2412826568","https://openalex.org/W1576088629","https://openalex.org/W2090339630","https://openalex.org/W1560115230"],"abstract_inverted_index":{"Native":[0],"muscle":[1,109],"phosphofructokinase":[2],"(PFK:":[3],"EC":[4],"2.7.1.11)":[5],"isolated":[6],"from":[7,65],"25-":[8],"and":[9,79,83],"100-week-old":[10,60,96],"rats":[11,97],"was":[12,50],"subjected":[13],"to":[14,52,88],"in":[15,21,69,98,108,116],"vitro":[16],"studies":[17],"on":[18],"fructose-2,6-bisphosphate-induced":[19],"alterations":[20,107],"the":[22,57,70,93],"regulatory":[23],"roles":[24],"of":[25,30,37,59,72,81,95,102,122],"other":[26],"key":[27],"metabolic":[28],"modulators":[29],"this":[31,117],"enzyme.":[32],"Although":[33],"fructose":[34],"2,6-bisphosphate-mediated":[35],"reversal":[36,80],"citrate":[38],"inhibition":[39],"did":[40],"not":[41],"show":[42],"any":[43],"age-related":[44],"difference,":[45],"synergism":[46,75],"with":[47,56,76,92,100],"glucose-1,6-bisphosphate":[48],"effect":[49],"found":[51],"be":[53,89],"slightly":[54],"increased":[55],"enzyme":[58,94,118],"rats.":[61,104],"In":[62],"addition,":[63],"apart":[64],"a":[66,120],"significant":[67],"decrease":[68],"extent":[71],"fructose-2,6-bisphosphate":[73],"activation,":[74],"AMP":[77],"activation":[78],"ATP":[82],"pyridoxal-5-phosphate":[84],"inhibitions":[85],"were":[86],"observed":[87],"decreased":[90],"markedly":[91],"comparison":[99],"that":[101],"25-week-old":[103],"Such":[105],"age-dependent":[106],"PFK":[110],"provide":[111],"evidence":[112],"for":[113],"conformational":[114],"modification":[115],"as":[119],"function":[121],"age.":[123]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
