{"id":"https://openalex.org/W2397963301","doi":null,"title":"Immunohistochemical determination of the estrogen receptor content of gastrointestinal adenocarcinomas.","display_name":"Immunohistochemical determination of the estrogen receptor content of gastrointestinal adenocarcinomas.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W2397963301","mag":"2397963301","pmid":"https://pubmed.ncbi.nlm.nih.gov/1456602"},"language":"en","primary_location":{"id":"pmid:1456602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1456602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American surgeon","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082873796","display_name":"Brandy Cameron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B L Cameron","raw_affiliation_strings":["Department of Surgery, Harbor-UCLA Medical Center, Torrance"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Harbor-UCLA Medical Center, Torrance","institution_ids":["https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110211052","display_name":"Janet A. Butler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Butler","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043578136","display_name":"Joanne K.L. Rutgers","orcid":"https://orcid.org/0000-0003-0012-5885","observed_orcids":["https://orcid.org/0000-0003-0012-5885"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Rutgers","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103458099","display_name":"Hernan I. Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H I Vargas","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063797089","display_name":"Michael Purtell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Purtell","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":null,"display_name":"B Sheppard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Sheppard","raw_affiliation_strings":["University of California at Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3325,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.52267819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":"12","first_page":"758","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gastrointestinal-adenocarcinoma","display_name":"gastrointestinal adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nuclear-estrogen-receptor","display_name":"nuclear estrogen receptor","score":0.4189999997615814},{"id":"https://openalex.org/keywords/hormone-dependent-cancers","display_name":"hormone-dependent tumors","score":0.4189999997615814},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.802501916885376},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.7513352632522583},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7367520332336426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6825417280197144},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6481386423110962},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45446884632110596},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.449947714805603},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.43774956464767456},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3145715594291687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21487265825271606}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006785","descriptor_name":"Hospitals, University","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006787","descriptor_name":"Hospitals, Veterans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015141","descriptor_name":"Los Angeles","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1456602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1456602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American surgeon","raw_type":"Journal Article"},{"id":"mag:2397963301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1456602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083225700","https://openalex.org/W580871597","https://openalex.org/W2065479193","https://openalex.org/W7063362264","https://openalex.org/W2312710737","https://openalex.org/W2004196062","https://openalex.org/W3162847539","https://openalex.org/W1603248220","https://openalex.org/W2316906097","https://openalex.org/W1968982431"],"abstract_inverted_index":{"Recently":[0],"there":[1],"have":[2],"been":[3],"several":[4],"reports":[5],"documenting":[6],"the":[7,19,40,45,85,91,105,110,126,157,168,187,191,241],"presence":[8,41],"of":[9,42,90,107,112,146,156,167,180,186,213,221,233,240],"estrogen":[10],"receptors":[11],"(ERs)":[12],"in":[13],"human":[14],"gastrointestinal":[15],"(GI)":[16],"malignancies,":[17],"raising":[18],"possibility":[20],"that":[21],"these":[22],"cancers":[23,54,159,170],"may":[24],"be":[25,122],"hormonally":[26],"manipulated.":[27],"To":[28],"test":[29],"this":[30],"hypothesis,":[31],"68":[32],"frozen":[33],"GI":[34],"tissue":[35,62],"specimens":[36,63,205],"were":[37,52,75,151,160,171,206],"examined":[38],"for":[39,88,125,194,208],"ERs":[43],"within":[44],"cell":[46,113,188],"nuclei":[47,114,189],"by":[48,84],"immunohistochemical":[49],"staining.":[50],"There":[51],"51":[53],"(25":[55],"gastric,":[56,65],"26":[57,222],"colon)":[58],"and":[59,109,137,202,218],"17":[60],"normal":[61,204],"(six":[64],"11":[66],"colon).":[67],"Tissue":[68],"sections":[69],"4":[70],"to":[71,100,121,174,236],"6":[72],"microns":[73],"thick":[74],"incubated":[76],"with":[77],"monoclonal":[78],"antibody":[79],"H222SP":[80],"psi,":[81],"then":[82],"stained":[83],"peroxidase-antiperoxidase":[86],"technique":[87],"visualization":[89],"ER.":[92,209],"The":[93,134],"staining":[94,108,179,232],"was":[95,128],"semiquantitatively":[96],"graded":[97],"from":[98],"0":[99],"3+":[101],"depending":[102],"on":[103],"both":[104],"intensity":[106],"percentage":[111],"stained.":[115],"A":[116],"breast":[117],"cancer":[118,140],"specimen":[119],"known":[120],"strongly":[123],"positive":[124,132,197,207],"ER":[127,196],"used":[129],"as":[130,190],"a":[131,143],"control.":[133],"30":[135],"male":[136],"21":[138],"female":[139],"patients":[141],"had":[142],"median":[144],"age":[145],"59":[147],"years.":[148],"All":[149],"tumors":[150,201,225],"adenocarcinomas.":[152],"Eight":[153],"per":[154,165,184,238],"cent":[155,166,185,239],"gastric":[158,216],"poorly":[161],"differentiated,":[162],"while":[163],"94":[164],"colon":[169,224],"moderately":[172],"well":[173,175],"differentiated.":[176],"Using":[177],"weak":[178,231],"at":[181],"least":[182],"20":[183],"minimum":[192],"requirement":[193],"an":[195],"tumor":[198,242],"(1+,":[199],"0/51":[200],"0/17)":[203],"Only":[210],"three":[211],"out":[212,220],"25":[214],"(12%)":[215],"tumors,":[217],"two":[219],"(8%)":[223],"demonstrated":[226],"any":[227],"staining;":[228],"each":[229],"exhibited":[230],"only":[234],"five":[235],"ten":[237],"nuclei.(ABSTRACT":[243],"TRUNCATED":[244],"AT":[245],"250":[246],"WORDS)":[247]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
