{"id":"https://openalex.org/W2397956744","doi":"https://doi.org/10.1182/blood.v87.3.999.bloodjournal873999","title":"TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1","display_name":"TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W2397956744","doi":"https://doi.org/10.1182/blood.v87.3.999.bloodjournal873999","mag":"2397956744","pmid":"https://pubmed.ncbi.nlm.nih.gov/8562972"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v87.3.999.bloodjournal873999","doi":"https://doi.org/10.1182/blood.v87.3.999.bloodjournal873999","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v87.3.999.bloodjournal873999","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003189331","display_name":"Hiroshi Kamesaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Kamesaki","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110353034","display_name":"Ginette Y. Michaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"GY Michaud","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108362126","display_name":"S G Irving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SG Irving","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065091642","display_name":"Naruyoshi Suwabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Suwabe","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039895467","display_name":"Saori Kamesaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Kamesaki","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Okuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Okuma","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071422834","display_name":"J Cossman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Cossman","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286296"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405286296"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.6101,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.68794326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"87","issue":"3","first_page":"999","last_page":"1005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gata1","display_name":"GATA-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gata2","display_name":"GATA2","score":1.0},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9539999961853027},{"id":"https://openalex.org/keywords/differentiation-arrest","display_name":"differentiation arrest","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.81651771068573},{"id":"https://openalex.org/C43821964","wikidata":"https://www.wikidata.org/wiki/Q18025461","display_name":"GATA2","level":4,"score":0.508841335773468},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4995729923248291},{"id":"https://openalex.org/C142455686","wikidata":"https://www.wikidata.org/wiki/Q59250989","display_name":"GATA transcription factor","level":5,"score":0.4478856921195984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43698546290397644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42328202724456787},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4012535512447357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3239307999610901},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.17380306124687195},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14743924140930176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1339932382106781},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.09650081396102905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0882924497127533},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050981","descriptor_name":"Erythroid-Specific DNA-Binding Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050989","descriptor_name":"GATA2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v87.3.999.bloodjournal873999","doi":"https://doi.org/10.1182/blood.v87.3.999.bloodjournal873999","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v87.3.999.bloodjournal873999","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:8562972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8562972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W17145292","https://openalex.org/W197013897","https://openalex.org/W199379996","https://openalex.org/W1484653647","https://openalex.org/W1488598317","https://openalex.org/W1489612807","https://openalex.org/W1493828862","https://openalex.org/W1512607533","https://openalex.org/W1565760095","https://openalex.org/W1572314871","https://openalex.org/W1600980555","https://openalex.org/W1675282228","https://openalex.org/W1774620689","https://openalex.org/W1837504142","https://openalex.org/W1946088674","https://openalex.org/W1978713358","https://openalex.org/W1993135323","https://openalex.org/W1998490733","https://openalex.org/W2007815804","https://openalex.org/W2024709301","https://openalex.org/W2033597225","https://openalex.org/W2046121370","https://openalex.org/W2048437870","https://openalex.org/W2055568103","https://openalex.org/W2061183445","https://openalex.org/W2069495256","https://openalex.org/W2071311716","https://openalex.org/W2084195942","https://openalex.org/W2086548325","https://openalex.org/W2089019735","https://openalex.org/W2089461678","https://openalex.org/W2094431012","https://openalex.org/W2116608195","https://openalex.org/W2124213741","https://openalex.org/W2134812217","https://openalex.org/W2151396228","https://openalex.org/W2183826319","https://openalex.org/W2186641436","https://openalex.org/W2264211064","https://openalex.org/W2411807590","https://openalex.org/W2413015229","https://openalex.org/W2422918612","https://openalex.org/W6982263260"],"related_works":["https://openalex.org/W2048437870","https://openalex.org/W2128646124","https://openalex.org/W2004668804","https://openalex.org/W2264211064","https://openalex.org/W1512607533","https://openalex.org/W4310161003","https://openalex.org/W24747404","https://openalex.org/W2028024336","https://openalex.org/W2049117415","https://openalex.org/W2273268696"],"abstract_inverted_index":{"GATA-1":[0,49,67,112,125],"protein":[1,52,70,128],"is":[2,98,119],"thought":[3],"to":[4,23],"be":[5],"a":[6,16,28,72],"positive":[7],"regulator":[8],"of":[9,15,35,48,66,87,95,103,111,124],"erythroid":[10,25,36,55,74,96,131],"differentiation.":[11,56,132],"However,":[12],"ectopic":[13],"expression":[14],"conditional":[17],"GATA-2/estrogen":[18],"receptor":[19],"chimera":[20],"was":[21],"shown":[22],"inhibit":[24],"differentiation":[26,37,97],"in":[27,71],"hormone-dependent":[29],"manner,":[30],"suggesting":[31],"the":[32,45,85,101,109,120],"negative":[33],"regulation":[34],"by":[38],"GATA-2":[39,51,69,104,127],"protein.":[40,113],"Accordingly,":[41],"we":[42,60,90],"reasoned":[43],"that":[44,92,117,129],"quantitative":[46,64,122],"balance":[47,123],"and":[50,63,68,126],"might":[53],"affect":[54],"In":[57],"this":[58],"report,":[59],"performed":[61],"specific":[62],"measurements":[65],"new":[73],"cell":[75],"line,":[76],"SAM-1,":[77],"after":[78],"treatment":[79],"with":[80,100],"12-O-tetradecanoylphorbol":[81],"13-acetate":[82],"(TPA).":[83],"On":[84],"basis":[86],"these":[88],"measurements,":[89],"show":[91],"TPA-induced":[93],"arrest":[94],"coupled":[99],"upregulation":[102],"protein,":[105],"as":[106,108],"well":[107],"downregulation":[110],"Our":[114],"results":[115],"suggest":[116],"it":[118],"precise":[121],"regulates":[130]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
